Irrigation solution and method for inhibition of tumor cell adhesion, pain and inflammation

Abstract

A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokininl antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykininl antagonist, a bradykinin2 antagonist and a mu -opioid agonist.

Description

Invention field [0001] The present invention relates to the use of a combination of local delivery of therapeutic agents during perioperative period to inhibit tumor cell adhesion and / or invasion and / or local tumor cell metastasis, and at the same time to treat pain and / or inflammation and / or smooth muscle spasm during surgical operation. / Or method of restenosis. Background of the invention [0002] Endoscopy is a surgical operation in which a camera connected to a remote light source and a video monitor is inserted into a body cavity (such as joints, peritoneal cavity, bladder, etc.) through small incisions in the overlying skin and body wall. , Thorax, etc.). With the help of similar incisions, surgical instruments can be inserted into the body cavity, and their application can be guided by arthroscopy. With the improvement of endoscopists' skills, more and more surgical operations that once required "open" surgical techniques can now be achieved through endoscopy. These oper...

AI Technical Summary

Problems solved by technology

A second study indicated that oral amitriptyline actually made postoperative patients feel less good overall, possibly due to the drug's affinity for various amine receptors in the brain

(3) Due to the existence of multiple inflammatory mediators, and studies have confirmed that there is a synergistic effect between these inflammatory mediators, blocking only one substance (5-HT) is not sufficient to inhibit inflammation in response to tissue damage

Topical application of histamine receptor antagonists has not currently been used in the perioperative setting, precisely because certain side effects (such as sedation) have been associated with the above-mentioned high "narcotic" concentrations of histamine receptor antagonists

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