Combination of ligusticum lactone, preparation method and application
A technology of ligustilide and its composition, which is applied in the field of ligustilide composition and its preparation, can solve the problems of instability of ligustilide, difficulty in preparation and inability to learn from it, and reduce microvascular leakage, reduce Mortality rate, effect of shortening ear-eye cycle time
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0040] Example 1:
[0041] 295g of ligustilide was dissolved in 2680g of soybean oil, and the conventional soft capsule preparation technology was used to prepare a soft capsule with a filling capacity of 250 mg. After being placed at room temperature for one and a half years, the contents were basically stable. The results are shown in Table 3.
[0042] Placement conditions
Example Embodiment
[0043] Example 2:
[0044] Add 5kg soybean oil (injected by vacuum) in the batching tank, heat up to 80°C, add 0.6kg lecithin, stir for 5-8 minutes, add 250g of ligustilide after all the lecithin is dispersed, turn on the circulation pump, Mix the oil in the batching tank with the glycerin in proportion, and turn on high-speed stirring. Sodium hydroxide solution (1moL / L) was added to adjust the pH to 6.0-7. Stop stirring, add filtered water for injection to the full amount of 50000ml, stir evenly, it is a primary emulsion, measure the glycerol content, pH value (glycerol content 95%-105%, pH value: 6.0-7.0). Cool the primary emulsion to 55-60 ℃, start the low-pressure homogenizer, let the primary emulsion circulate and homogenize in the machine, start the high-pressure homogenizer, let the emulsion enter the machine for circulation and homogenization, and repeat the homogenization 10 times. After the first 9 times of homogenization, the emulsion was cooled to about 50-55 ℃ t...
Example Embodiment
[0046] Example 3
[0047] 60g of ligustilide was dissolved in 3000g of soybean oil, and a soft capsule of 250mg was prepared by using technology. After being placed at room temperature for one and a half years, the contents were basically stable. The results are shown in Table 5.
[0048] Placement conditions
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap