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Cough treating orally disintegrating tablet

A technology of orally disintegrating tablets and disintegrants, applied in the field of dextromethorphan hydrobromide orally disintegrating tablets, can solve the problems of inconvenient carrying, inconvenient taking, poor stability, etc., and achieve easy carrying and taking, and fast onset of action , the effect of moderate hardness

Inactive Publication Date: 2006-01-18
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing dextromethorphan hydrobromide formulations for treating cough are common tablets and oral liquid preparations for children. The dissolution time of common tablets is generally limited to 30 minutes, and the dissolution amount is 80% of the labeled amount. It is extremely inconvenient for people with disabilities and inconvenient water intake
Oral liquid preparations are inconvenient to carry and have poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1. The orally disintegrating tablet for treating cough is made of the following components:

[0016] Dextromethorphan Hydrobromide 7.5g

[0017] Microcrystalline Cellulose 32.0g

[0018] Mannitol 28.0g

[0019] Lactose 20.0g

[0020] Precrossed Starch 6.0g

[0021] Cross-linked polyvinylpyrrolidone 18.0g

[0022] Aspartame 0.5g

[0023] Peppermint essence 0.1ml

[0024] Micropowder silica gel 1.0g,

[0025] A total of 1000 pieces were made.

[0026] The specific preparation method is as follows: respectively pulverize dextromethorphan hydrobromide, microcrystalline cellulose, mannitol, lactose, precrossified starch, cross-linked polyvinylpyrrolidone, aspartame, and micronized silica gel through a 120-mesh sieve, press The formula quantity is weighed. First mix dextromethorphan hydrobromide with aspartame, mannitol, lactose, and precrossed starch evenly, then mix evenly with 2 / 3 amount of microcrystalline cellulose, half amount of cross-linked polyvin...

Embodiment 2

[0027] Embodiment 2. In this embodiment, the orally disintegrating tablet for treating cough is made of the following components:

[0028] Dextromethorphan Hydrobromide 15.0g

[0029] Microcrystalline Cellulose 30.0g

[0030] Mannitol 30.0g

[0031] Lactose 22.0g

[0032] Precrossed Starch 6.0g

[0033] Cross-linked polyvinylpyrrolidone 10.0g

[0034] Croscarmellose Sodium 10.0g

[0035] Stevioside 1.0g

[0036] Mint essence 0.2ml

[0037] Magnesium stearate 0.8g,

[0038] A total of 1000 pieces were made.

[0039] The specific preparation method is as follows: dextromethorphan hydrobromide, microcrystalline cellulose, mannitol, lactose, precrossified starch, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, stevioside, hard Magnesium acid was crushed and passed through a 120-mesh sieve, and the formula was weighed. First, dextromethorphan hydrobromide and steviol glycoside were fully mixed, then mannitol, lactose and precrossed starch we...

Embodiment 3

[0040] Embodiment 3. In this embodiment, the orally disintegrating tablet for treating cough is made of the following components:

[0041] Dextromethorphan Hydrobromide 30.0g

[0042] Microcrystalline Cellulose 28.0g

[0043] Mannitol 30.g

[0044] Lactose 18.0

[0045] Sodium Low-Substituted Hydroxypropyl Cellulose 12.0g

[0046] Croscarmellose Sodium 10.0g

[0047] Aspartame 0.8g

[0048] Stevioside 0.6g

[0049] Mint essence 0.2ml

[0050] Micronized silica gel 0.4g

[0051] Magnesium stearate 0.5g,

[0052] A total of 1000 pieces were made.

[0053] The specific preparation method is as follows: dextromethorphan hydrobromide, microcrystalline cellulose, mannitol, lactose, low-substituted hydroxypropyl cellulose sodium, croscarmellose sodium, stevioside, aspirin Batame, micropowder silica gel, and magnesium stearate were crushed through a 120-mesh sieve, and weighed according to the formula. First, fully mix dextromethorphan hydrobromide, aspartame, and steviol gl...

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PUM

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Abstract

The invention discloses an oral disintegrating tablet for treating cough, whose medicinal active component is dextromethorphan hydrobromide, the weight portions for each component are, dextromethorphan Hydrobromide 1 part, filling agent 1-30 parts, crumbling agent 0.4-5 parts, flavoring agent 0.01-0.08 part. The tablet has the advantages of right hardness, good taste, quick action, facilitated administration and carrying. Its disintegration time is superior to the common tablets, its stability is higher than the solution agent. The tablet is recommended for children, the aged people, patients with deglutition obstacle or in field operations.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a dextromethorphan hydrobromide orally disintegrating tablet for treating cough. Background technique [0002] Existing dextromethorphan hydrobromide formulations for treating cough are common tablets and oral liquid preparations for children. The dissolution time of common tablets is generally limited to 30 minutes, and the dissolution amount is 80% of the labeled amount. It is extremely inconvenient for people with disabilities and inconvenient water intake. Oral liquid preparations are not easy to carry and have poor stability. Contents of the invention [0003] The object of the present invention is to provide a kind of dextromethorphan hydrobromide orally disintegrating tablet for treating cough which is convenient to take. [0004] To achieve the above object, the present invention adopts the following technical scheme: an orally disintegrating tablet for treating cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/20A61P11/14
Inventor 岳淑梅许启泰于培明陈百泉
Owner HENAN UNIVERSITY
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