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Method for preparing formulation containing Indianmulberry extract

A technology of Morinda officinalis oligosaccharides and excipients, which is applied to medical preparations containing active ingredients, drug combinations, pill delivery, etc., can solve the problems of prolonged production cycle, large amount of excipients, and increased product costs, and achieve The effect of increasing the content rate, reducing product cost, and reducing the amount of auxiliary materials

Active Publication Date: 2006-02-22
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This objectively results in prolongation of the production cycle, increase in the number of preparation steps, reduction in yield and other technical deficiencies, as well as the difficulty in increasing the content of medicinal ingredients in the shaped granules, and insufficient quality such as large excipient doses, which increase the cost of the product and prevent patients from taking medicine. As the number increases, there are hidden dangers in product compliance

Method used

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  • Method for preparing formulation containing Indianmulberry extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Preparation of Morinda officinalis oligosaccharide granules formed at one time

[0019] In the GPCG1 fluidized bed, put 500 g of PH102 microcrystalline cellulose powder with a particle diameter of 0.20 mm (equivalent to passing through an 80-mesh sieve) into the fluidized bed, and set the following key parameters: inlet air temperature 40-45 °C , the air inlet pressure is 0.35bar~0.45bar, the atomization pressure is 1.5bar~2.0bar, and the spray rate is 15rpm~25rpm. Other parameters are fixed at: filter bag shaking frequency 6 times / min, shaking time 5 seconds / time, nozzle diameter 1.0mm, fluidization air volume before granulation 0.30bar, fluidization time 2-5 minutes. Concentrate the water extract medicinal solution obtained from Morinda officinalis as a raw material into 1000g of liquid extract with a specific gravity of 1.12-1.15, and spray it into the fluidized bed in the form of mist and bottom spray. The spray rate of the liquid medicine is carried out...

Embodiment 2

[0020] Example 2: Preparation of Morinda officinalis Oligosaccharide Capsules of 150mg Specification

[0021] The Morinda officinalis oligosaccharide granules prepared in Example 1 were filled into No. 2 ordinary hollow capsules according to the weight of 225 mg, and sealed with blisters of PVC hard sheets and aluminum foil, and the packaging specification was 12 capsules / board. Each capsule contains Morinda officinalis oligosaccharides 150mg.

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Abstract

The invention relates to a process for preparing morinda root oligosaccharide granule through the following steps: contacting morinda root extract with excipient in the form of liquid mist or drop at a predetermined temperature and air pressure, then hardening instantly to obtain the qualified medicament.

Description

technical field [0001] The present invention relates to the production of Morinda officinalis oligosaccharide granules or pellets which are obtained by contacting Morinda officinalis extract with excipients in the form of liquefied droplets at a certain temperature and certain air pressure, solidified instantaneously, and formed at one time. The method, and the formulation specifications of the Morinda officinalis oligosaccharide containing 50-150 mg / capsule prepared by the method. Background of the invention [0002] Morinda officinalis is a commonly used traditional Chinese medicinal material. Now, through systematic research, a new pharmacological effect of Morinda officinalis water extract has been found: the water extract of Morinda officinalis can increase the content of monoamine transmitters in the brain of mice with reserpine, reverse blood Effects of flattening abnormal behavior in mice. On behavioral models such as mouse tail suspension method and forced swimming...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61K31/715A61K9/20A61K9/48A61P25/24
Inventor 高春生杨明单利赵毅民梅兴国崔承彬
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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