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Rabdosia dripping pill and its preparing method

A technology of grass dripping pills and Rubescensica extracts, which are applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as the content of Rubescensine A, and achieve good dissolution and production. The effect of short cycle time and low production cost

Active Publication Date: 2006-03-22
河南百年康鑫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved in the present invention is to provide a kind of Rubescensae dripping pills and preparation method thereof, to solve the defect that the main active ingredient oridonin A content is very little in the existing Rubescensia tablets and syrup, to improve The content of the main active ingredients in the Oridonium preparations ensures its clinical curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Grind Cordyceps japonicus into coarse powder, use ethanol as solvent, soak, slowly infiltrate at a rate of 2ml per minute per kilogram of medicinal materials, collect the percolation liquid, concentrate, add activated carbon to decolorize at 50°C for 3 times, filter , concentrate, let cool, add ethyl acetate to extract 4 times, separate the ethyl acetate layer, combine, and recover the ethyl acetate under reduced pressure to a thick paste, which is the extract of Rubescens japonicus; Ethylene glycol 6000 The matrix is ​​mixed according to the ratio of 10:1 by weight to obtain a uniform mixture, and the above-mentioned mixture is heated to melt by using a water bath heating method, and then stirred evenly to obtain a uniform melt; the above-mentioned uniform melt is put into the dropping pill machine, adjusted and Keep its temperature at 70°C; drop it into 5°C methyl silicone oil condensing agent, wait for shrinkage and molding, take it out, remove the surface condensing...

Embodiment 2

[0029] Grind Cordyceps japonicus into coarse powder, use ethanol as a solvent, soak for 30 hours, slowly infiltrate at a rate of 3ml per minute per medicinal material, collect the percolation liquid, concentrate, add activated carbon and decolorize twice at 60°C , filter, concentrate, let cool, add ethyl acetate to extract 3 times, separate the ethyl acetate layer, combine, and recover ethyl acetate under reduced pressure to a thick paste, that is, the extract of Radix Ordisiae; Polyethylene Glycol 4000 The matrix is ​​mixed according to the ratio of 15:1 by weight to obtain a uniform mixture, and the above-mentioned mixture is heated to melt by using a water bath heating method, and then stirred evenly to obtain a uniform melt; the above-mentioned uniform melt is put into the dropping pill machine, adjusted and Keep its temperature at 78°C; drop it into a 15°C liquid paraffin condensing agent, wait for shrinkage and molding, take it out, remove the surface condensing agent, d...

Embodiment 3

[0031] Grind Cordyceps japonicus into a coarse powder, use ethanol as a solvent, soak for 36 hours, slowly infiltrate at a rate of 5ml per minute per kilogram of medicinal material, collect the percolation liquid, concentrate, add activated carbon and decolorize twice at 80°C, Filtrate, concentrate, let cool, add ethyl acetate to extract 5 times, separate the ethyl acetate layer, combine, and recover the ethyl acetate under reduced pressure to a thick paste, that is, the extract of Rubescens japonicus; Mix with polyoxyethylene monostearate base at a ratio of 17:1 by weight to obtain a homogeneous mixture, use an oil bath heating method, heat the above mixture to melt, and then stir evenly to obtain a uniform melt; Put the molten matter into the dropping pill machine, adjust and keep its temperature at 85°C; drop it into the liquid paraffin condensing agent at 20°C, wait for shrinkage molding, take it out, remove the surface condensing agent, dry, and pack to obtain the product ...

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PUM

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Abstract

The rabdosia dripping pill consists of rabdosia extract as the active component and one or several kinds of matrix, and through mixing and other steps. The rabdosia dripping pill has the functions of dispelling wind evil, clearing away heat, eliminating toxic matter, eliminating swelling, relieving pain, etc. and is used in treating acute and chronic tonsillitis, pharyngitis, laryngitis, stomatitis and other diseases. It has fast acting, small dosage, no toxicity, no side effect, and other features.

Description

【Technical field】 [0001] The present invention relates to a kind of medicine and its preparation method, more specifically, the present invention relates to a kind of oridonium grass dropping pill and its preparation method. 【Background technique】 [0002] Dongling grass is the dry above-ground part of the Lamiaceae Camellia plant. It has the functions of dispelling wind and clearing heat, detoxifying and relieving sore throat, reducing swelling and relieving pain. Five kinds of diterpenoids were isolated from the ethanol extract of the leaves of Rubescens japonicus, namely Rubescens A, B, C, D and valerin, all of which are tetracyclic diterpenoids of Kaurene skeleton type. Donglingcao preparation is a commonly used drug. Its antibacterial and anti-inflammatory effects have been clinically used so far, and it is one of the first-choice drugs for the treatment of upper respiratory tract infections such as acute and chronic tonsillitis, pharyngitis, laryngitis and other disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/20A61P11/04
Inventor 冀春茹袁珂董玉秀丁永志蔡俊安
Owner 河南百年康鑫药业有限公司
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