Compound film rubber cork and its preparation method

A technology of rubber stoppers and rubber stoppers, applied in the field of compound film rubber stoppers and their preparation, can solve the problems of harming patients, poor airtightness, easy moisture absorption and mildew, etc., to save equipment and costs, avoid direct contact, and facilitate industrialization Effect

Inactive Publication Date: 2006-03-29
刘永红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason why natural rubber plugs have been completely eliminated is because of the following disadvantages: 1. Poor biological safety, easy to absorb moisture and become moldy; 2. The heterosexual protein dissolved from natural rubber plugs is one of the important factors that lead to human heat sources; 3. The dissolved pyridine compounds are easy to cause cancer, teratogenicity and mutagenesis; 4. The chemical properties are relatively active and easy to interact with drugs; 5. The air tightness is poor; it has a high diffusion rate for various gases; 6. , During sterilization, a large number of harmful residual chemical accelerators, vulcanizing agents, heavy metals in auxiliary materials, proteins and other substances migrate concentratedly into the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 lamination rubber stopper of the present invention

[0024] The polypropylene film and the unvulcanized natural rubber sheet for infusion are tightly covered on the mold of the vacuum vulcanizer. In the mold, pressurize 15-20 Pa at a temperature of 160 °C, and vacuumize to make a rubber plug shape, and the film is tightly pressed on the rubber. Plug the bottom. Trim away the edges.

Embodiment 2

[0025] The preparation of embodiment 2 lamination rubber stopper of the present invention

[0026] The polyethylene film and the unvulcanized powder needle are tightly covered on the mold of the vacuum vulcanizer with a natural rubber sheet. In the mold, pressurize 15-20 Pa at a temperature of 120 °C, and vacuumize to make a rubber plug shape. Bottom side of rubber stopper. Trim away the edges.

Embodiment 3

[0027] Example 3 The preparation of laminating rubber stopper of the present invention

[0028] The polyester film and the unvulcanized polyisoprene film are tightly covered on the mold of the vacuum vulcanizer. In the mold, pressurize 15-20 Pa at a temperature of 110 °C, and vacuumize to make a rubber plug shape. Bottom side of rubber stopper. Trim away the edges.

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PUM

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Abstract

A film covered rubber plug is composed of a rubber plug and a covering high-molecular film chosen from polyethene, polypropene, polyester and polystyrene. Said film has a fusion point close to that of rubber and is directly and physically adhered onto surface of rubber plug without adhesive.

Description

technical field [0001] The invention relates to a medicinal rubber stopper and a preparation method thereof, in particular to a laminated rubber stopper and a preparation method thereof. Background technique [0002] The State Food and Drug Administration Document No. 462 stipulates that from January 1, 2005, all medicine packaging bottles will stop using natural rubber stoppers, and use butyl rubber stoppers or coated or laminated rubber stoppers instead. The reason why the natural rubber stopper was completely eliminated is because of the following shortcomings: 1. The biological safety is poor, and it is easy to absorb moisture and mold; 2. The heterosexual protein dissolved from the natural rubber stopper is one of the important factors that cause the heat source of the human body; 3. The dissolved pyridine compounds are easily carcinogenic, teratogenic and mutagenic; 4. The chemical properties are relatively active, and it is easy to interact with drugs; 5. The air tigh...

Claims

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Application Information

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IPC IPC(8): B65D39/18A61J1/14B29C35/02B29K23/00B29K67/00B29K27/18
Inventor 刘永红
Owner 刘永红
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