Biodegradable film having honeycomb structure

A honeycomb structure and biological technology, applied in medical science, surgery, coating, etc., to achieve the effects of easy handling, improved safety, and high biocompatibility

Active Publication Date: 2006-07-19
TEIJIN LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] As such, biocompatibility becomes a big problem when using a thin film with a fine structure for the purpose of being used in living tissue

Method used

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  • Biodegradable film having honeycomb structure
  • Biodegradable film having honeycomb structure
  • Biodegradable film having honeycomb structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] In the chloroform solution (5g / L) of polylactic acid (molecular weight 100000), mix the polyacrylamide copolymer (weight average molecular weight: 85,000) shown in compound formula 1 as amphiphilic polymer with the ratio of 10:1, in The honeycomb structure was prepared by casting on a glass substrate, leaving still at room temperature and a humidity of 70%, and slowly evaporating the solvent. The honeycomb structure of the thus obtained structure had a cell inner diameter of 5 μm and a film thickness of 13 μm. Optical microscope photographs such as figure 1 shown.

Embodiment 2

[0051] In a chloroform solution (5 g / L) of polylactic acid-polyglycolic acid copolymer (copolymer ratio 75:25, molecular weight 100,000), a polyacrylamide copolymer as an amphiphilic polymer was mixed in a ratio of 10:1, The honeycomb structure was prepared by casting on a glass substrate, leaving still at room temperature and a humidity of 70%, and slowly evaporating the solvent. The honeycomb structure of the thus obtained structure had a cell inner diameter of 5 μm and a film thickness of 13 μm.

[0052] The structural formula of the polyacrylamide copolymer used is shown below.

[0053]

[0054] (m, n represent repeating units, m:n=1:4.)

Embodiment 3

[0060] Male SPF hairless rats (average body weight 250g) were anesthetized by intraperitoneal injection, the abdomen was incised to expose the stomach, and then a wound of about 8 mm was made on the epidermis of the bottom wall of the stomach, and Examples 1, 2 and Comparative Example 1 were applied. , 2 The anti-adhesion materials (3cm square) obtained respectively, one for each rat. After applying the anti-adhesion material, a necropsy was performed one week later, and the adhesion state was observed with the naked eye. The adhesion state of each rat is shown in Table 1 below.

[0061] The honeycomb structure films of Examples 1 and 2 did not gel or dissolve when immersed in water, and since the films were soft, they were easy to stick to the affected area and had good handling properties. There is no obvious inflammatory reaction, so it can be seen that the anti-adhesion material obtained by the present invention has good biocompatibility. The cast films of Comparative Exa...

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Abstract

The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.

Description

technical field [0001] The present invention relates to anti-adhesion materials for preventing postoperative adhesions. More specifically, it relates to an anti-adhesion material formed of a biodegradable film having a honeycomb structure. The anti-blocking material of the present invention has excellent handling properties, is stable for a desired period, and exhibits a good anti-blocking effect. Background technique [0002] Tissue adhesion, which is one of the physiological effects after surgery, is defined as the abnormal bonding of surrounding tissues, organs, etc. due to the production of collagen fibers by fibroblasts that accompanies tissue damage. Such adhesion occurs at a rate of 90% after surgery, and when it causes pain, biological dysfunction, etc., it causes mental and physical pain to the patient and becomes a problem. [0003] Many studies have been conducted to solve this problem. For example, in order to minimize adhesion formation, water-soluble anti-ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00B29C41/12
Inventor 福平由佳子北园英一兼子博章鹫见芳彦下村政嗣田中贤
Owner TEIJIN LTD
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