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Method for preparing calcium phosphate containing chinese medicine

A technology of calcium phosphate and traditional Chinese medicine, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, can solve the problems of not fully satisfying the requirements of treatment, reducing the efficacy of traditional Chinese medicine, and high production costs, avoiding heat The effect of denaturation failure, improving the use effect, and reducing the production cost

Inactive Publication Date: 2006-08-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the traditional Chinese medicine injection or the active ingredient extract is added after the calcium phosphate is generated, a large amount of traditional Chinese medicine exists in the suspended liquid phase, which is not easy to combine with the precipitated calcium phosphate, so that the amount of traditional Chinese medicine combined with calcium phosphate is limited, resulting in waste; at the same time, the combination of traditional Chinese medicine and calcium phosphate is weak
In this way, after the biomaterial containing Chinese medicine calcium phosphate is implanted in the body, the limited content of Chinese medicine cannot fully meet the requirements of curing diseases; the release speed of Chinese medicine weakly combined with calcium phosphate is too fast, and the purpose of slow, stable and effective release cannot be achieved, and it is difficult to meet the requirements of medical treatment. Requirements for long-term release and slow administration in clinical orthopedic treatment
Moreover, high-temperature spray-drying is required in the existing preparation method, the process is complex, and the production cost is high; moreover, high temperature also easily denatures and invalidates the ingredients of traditional Chinese medicines.
Reduced efficacy of traditional Chinese medicine in finished products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Ligustrazine injection containing 5 grams of Ligusticum chuanxiong extract dry matter was added to the solution containing 147.91 grams of calcium nitrate, and mixed evenly; then the solution containing 89.59 grams of ammonium phosphate was slowly added dropwise into the calcium nitrate solution, and the pH was controlled at 7 during the reaction. Left and right, the synthesis reaction was carried out under vigorous stirring at room temperature. After the dropwise addition, the calcium-deficiency apatite precipitate containing the effective extract of ligustrazine traditional Chinese medicine with a dry matter content of 100 grams was synthesized. After sufficient aging, washing and drying, the precipitate is prepared into calcium-deficient apatite powder containing ligustrazine.

Embodiment 2

[0016] Add compound danshen injection containing 16 grams of dry matter of compound danshen extract to a solution containing 88.79 grams of sodium phosphate, mix well, then quickly add to a solution containing 90.17 grams of calcium chloride, and control the pH at about 7 during the reaction , under vigorous stirring at room temperature for the synthesis reaction. After the dropwise addition was completed, the precipitate was immediately filtered and washed repeatedly, and then 100 grams of amorphous calcium phosphate precipitate containing the effective extract of Danshen traditional Chinese medicine was synthesized and dried to prepare the amorphous calcium phosphate powder containing Danshen.

Embodiment 3

[0018] Add safflower injection containing 50 grams of safflower extract dry matter to a solution containing 63.39 grams of potassium phosphate, mix well, then slowly add to a solution containing 81.83 grams of calcium nitrate, and control the pH at about 7 during the reaction , under vigorous stirring at room temperature for the synthesis reaction. The hydroxyapatite precipitation containing the effective extract of safflower traditional Chinese medicine with 100 grams of dry matter was synthesized. After sufficient aging, cleaning and drying of the precipitate, the safflower-containing hydroxyapatite powder can be obtained.

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Abstract

The present invention discloses a preparation method of calcium phosphate containing Chinese medicine. Said preparation method includes the following steps: adding the effective dose of Chinese medicine injection or Chinese medicine effective component extract capable of promoting union or curing orthopedic diseases into phosphate solution and / or calcium salt solution and / or reaction solution of phosphate solution and calcium salt solution, uniformly mixing them, making them produce reaction to form calcium phosphate suspension containing Chinese medicine, aging, cleaning and drying so as to obtain the invented product.

Description

Technical field [0001] The invention relates to a method for preparing calcium phosphate, in particular to a method for preparing calcium phosphate containing traditional Chinese medicine. Background technique [0002] The existing calcium phosphate containing traditional Chinese medicine is the patent application "calcium phosphate / traditional Chinese medicine composite bone replacement material and its preparation method" with application number 200310110705.0 filed by the applicant. The calcium phosphate containing traditional Chinese medicine is formed by compounding calcium phosphate biomaterials and active ingredients of traditional Chinese medicine with the function of promoting bone healing. The calcium phosphate implanted in the bone defect can better fill the bone defect and rebuild the bone continuity, and can release a certain amount of calcium ions and phosphate ions at the implantation site to increase the local concentration of calcium ions and phosphate ions ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K33/42A61P19/08
Inventor 翁杰屈树新黄婵鲁雄
Owner SOUTHWEST JIAOTONG UNIV