Method for preparing capsaicin carrier

A capsaicin and transfer body technology, applied in directions such as non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve problems such as expensive equipment, reduce preparation costs, reduce equipment costs, reduce toxic side effects

Inactive Publication Date: 2006-09-06
广州玑本宫贸易有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problem of expensive equipment in the existing preparation method of capsaicin transfer body, and provide a low-cost preparation method of capsaicin transfer body

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0015] Take 7 grams of lecithin, 1.5 grams of sodium cholate, 0.002 grams of vitamin E, and 0.05 grams of capsaicin dissolved in absolute ethanol, and put the stator-rotor head of the high-shear dispersing emulsification homogenizer deep into the 45 °C containing chlorobutanol 0.5% (g / ml) aqueous solution, about 5mm from the bottom of the beaker, turn on the high-shear dispersing emulsification homogenizer, add the above ethanol solution into the aqueous solution from the part close to the stator-rotor head, keep the aqueous solution at 45°C, and stir it magnetically Hydrate for 1 hour to obtain the capsaicin transfer body, the concentration of which is 7 grams of lecithin, 1.5 grams of sodium cholate, 0.05 grams of capsaicin, and 0.002 grams of vitamin E per 100 milliliters of the solution. The encapsulation efficiency of the obtained capsaicin transfersome reaches 97%.

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Abstract

This invention discloses a method for preparing capsaicin carrier. This method dissolves proper ratios of lecithin, sodium cholate, vitamin E and capsaicin with straight alcohol, embed the stator-rotor head of high-shearing dispersion uniformly emulsion machine into 45deg C aqueous solution( containing 0.5% 3-chloroisobutol), turn on the high-shearing dispersion uniformly emulsion machine, then drip the alcohol solution into the aqueous solution slowly from near stator-rotor head part, hold 45deg C, magnetic stirrer for 1 hour, the capsaicin carrier is obtained. This invention uses high-shearing dispersion uniformly emulsion machine to prepare capsaicin carrier, the equipment greatly reduces equipment cost (needs 6 thousand RMB only) and depresses preparation costú”At the same time, the prepared capsaicin carrier vesicle debased the toxic side effect in using and has good skin passing function.

Description

technical field [0001] The invention relates to the field of pharmaceutical compounds, in particular to a preparation method of a drug delivery body. Background technique [0002] According to the figures provided by the World Health Organization, there are currently about 350 million arthritis patients in the world. my country has a large population and 150 million patients with various types of arthritis. Many elderly people suffer from different degrees of osteoarthritis, the incidence rate of osteoarthritis in people over the age of 50 is 50%, and the incidence rate of elderly people in their 70s is as high as 80%. Guangdong belongs to the southern region with a humid climate, and such diseases are particularly common. These diseases can be treated but not cured. The goal of treatment is to reduce inflammation and pain, and promote functional recovery. Chemical drugs are still the main method for the treatment of such diseases. At present, in addition to steroidal anti...

Claims

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Application Information

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IPC IPC(8): A61K47/28A61K47/24A61K9/00A61K31/165A61P29/00A61P19/02
Inventor 龙晓英李坚李力任林丹
Owner 广州玑本宫贸易有限公司
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