Method for synthesizing O-ethoxy phenyl formamidine acetate

A technology of o-ethoxybenzamidine and ethoxybenzamidine, which is applied in the field of pharmaceutical intermediate synthesis, can solve the problem of high cost and achieve the effects of low cost, simple post-processing and simple process
CN1830955AInactive Publication Date: 2006-09-13SHANDONG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG NORMAL UNIV
Publication Date
2006-09-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for preparing o-ethoxybenzamidine acetate includes such steps as reflux reaction between o-ethoxy benzaldehyde and nitroethane to obtain o-ethoxy benzonitrile, reflux reacting on hydroxyammonium hydrochloride to obtain o-ethoxy benzamidoxime, and catalytic hydrogenating while stirring.
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Description

Technical field:

[0001] The invention belongs to the field of synthesis of pharmaceutical intermediates, and relates to a synthesis method of o-ethoxybenzamidine acetate. Background technique:

[0002] Studies have found that many natural products contain amidine compounds, which play a very important role in the life process, and aromatic substituted amidines are an important class of pharmaceutical intermediates, so many chemical synthesis methods have been reported. The common synthetic method is to prepare from amides, nitriles and thioamides. Among them, the methods with more market prospects are:

[0003] 1. Amides are oxy-alkylated by triethyloxonium fluoroborate at a mild temperature, and react with amines to form amidines.

[0004]

[0005] 2. Kakimoto reported a synthetic method for the direct conversion of carboxylic acid to amidine using trimethylsilyl polyphosphate (PPSE).

[0006]

[0007] 3. The Pinner reaction is the most classic method for preparing...

Claims

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