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Daphne freeze-drying powder injection and its preparation method

A freeze-dried powder injection and injection technology, which is applied in the field of pharmaceutical preparations, can solve problems such as difficult storage, poor stability, and difficult storage, and achieve the effects of easy storage, guaranteed stability, and guaranteed clarity

Inactive Publication Date: 2006-09-27
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Tablet dripping pills contain starch and / or hard acid and other substances. These substances are prone to mold and are not easy to store in an environment with high humidity and high temperature. Moreover, tablets and dropping pills are administered orally and absorbed by the stomach. , the effect is slow, the injection is given by injection, and the effect is fast, but its stability is poor and it is not easy to store

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The freeze-dried powder injection of Zushima for injection of the present embodiment uses 1000 grams of Zushima root bark and stem bark as raw materials, and the extract obtained by the single percolation method is filtered and distilled under reduced pressure to recover ethanol. Diluted with sterile water for injection or concentrated under reduced pressure to a solution equivalent to 1 gram of root bark and stem bark of Zushima, refrigerate, filter, adjust pH to 3.5, refrigerate, filter, adjust pH to 1.5, reflux, and adjust pH again To 7, add activated carbon for injection, add mannitol, make the solution contain 50mg / ml of mannitol, filter, and then freeze-dried to obtain Zushima freeze-dried powder injection.

[0043] The preparation method of a kind of Zu Shi Ma freeze-dried powder injection for injection of the present embodiment, comprises the following steps:

[0044] (1) Get the root bark and stem bark of 1000 grams of hemp, and carry out pretreatment. Said pre...

Embodiment 2

[0049] The operation method of the present embodiment and the equipment used are basically the same as those of the embodiment 1. The only difference is that the root bark and stem bark of 500 grams of Zushima are used as raw materials, and the extract is obtained by a single percolation method, filtered, and recovered by vacuum distillation. After ethanol, add sterile water for injection to dilute or concentrate under reduced pressure to a solution equivalent to 0.5 g of root bark and stem bark of Zushima root bark per milliliter of solution, refrigerate, filter, adjust pH to 3.0, refrigerate, filter, and then adjust pH to 1.2 , reflux, adjust the pH to 6.5, add activated carbon for injection, add mannitol to make the solution contain 100mg / ml of mannitol, filter, freeze-dry to form Zushima freeze-dried powder injection.

[0050] Its preparation method is:

[0051] (1) Take 500 grams of Zushima root bark and stem bark dry raw materials, pulverize the Zushima root bark and ste...

Embodiment 3

[0056] The operation method of this embodiment and the equipment used are basically the same as those in Embodiment 1, except that the root bark and stem bark of 1,500 grams of Zushima are used as raw materials, and the extract obtained by single percolation method is filtered and decompressed. After recovering ethanol by distillation, add sterile water for injection to dilute or concentrate under reduced pressure to a solution equivalent to 1.5 grams of root bark and stem bark of Zushima root bark per milliliter of solution, refrigerate, filter, adjust pH to 4.0, refrigerate, filter, and adjust pH again To 1.7, reflux, adjust the pH to 7.5, add activated carbon for injection, add mannitol, make the solution contain 200mg / ml of mannitol, filter, freeze-dry to form Zushi Ma freeze-dried powder injection.

[0057] Its preparation method is:

[0058](1) Take 1500 grams of root bark and stem bark dry raw materials of Zu Shi Ma, pulverize the root bark and stem bark dry raw materia...

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PUM

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Abstract

The present invention relates to freeze dried powder for injection prepared with the extract of root bark and stem bark of girald daphne. The preparation process is used in treating gall, stabbing pain, psychroalgia, etc. of limbs and trunk. It is prepared through a percolation process including extracting barked root and stem of girald daphne, filtering, decompression distillation to concentrate while recovering alcohol, re-filtering, regulating pH to 6.5-7.5 and resulting in mannitol concentration in the solution of 50-200mg / ml, filtering for the third time, and freeze drying. The freeze dried powder for injection has high curative effect and fast acting, and the low temperature vacuum drying process avoids the decomposition and oxidation of effective medicine components and results in high medicine stability.

Description

technical field [0001] The present invention relates to a medicinal preparation prepared by using plant material extracts and a preparation method thereof, more particularly a freeze-dried powder injection prepared from the extracts of the root bark and stem bark of Zushima and its preparation method. Background technique [0002] The chemical name of Daphnetin 7, 8-dihydoxycoumarin (7,8-dihydoxyCoumarin) is the active ingredient in the root bark and stem bark of Zushima. It can expand coronary blood vessels, increase coronary blood flow, reduce cardiac oxygen consumption, improve myocardial metabolism, and promote the recovery of cardiac function. [0003] Chinese Patent Document Application No. 93104946.0, published on November 9, 1994, and publication number CN1094627A reported Zushi hemp tablets and their preparation method, and the ingredient formula of Zushi hemp tablets is Zushi hemp extract (equivalent to methanol extract) 34.5% (weight) , starch 62.1% (weight), cal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K9/19A61P9/10A61K125/00
Inventor 丁钉生
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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