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Medicine powder for injection for treating cardiac and cerebral vascular diseases and its preparing method and application

A technology for cardiovascular and cerebrovascular diseases and powder injection, which is applied in the field of medicine, can solve the problems of loss of active ingredients, low purity, and difficulty in quantitatively refining the content of active ingredients in extracts, and achieves the effect of high content of active ingredients and good stability.

Active Publication Date: 2006-11-08
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. There is a certain loss of active ingredients during the infiltration process
[0006] 2. When slicing, there are individual slices with large thickness, which makes the extraction of active ingredients incomplete
[0008] 4. Ethanol recovery under atmospheric pressure is used in the existing process, and the active ingredients are easily decomposed by heat
[0009] 5. The dried extract contains more impurities and low purity, so it is difficult to quantitatively refine the active ingredient content of the extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Preparation of the powder injection for the treatment of cardiovascular and cerebrovascular diseases according to the present invention

[0045] (1) Take the dried notoginseng cut, crush it, add 85% ethanol of 2 times the amount of the crude drug, seal it, soak it at room temperature for 48 hours, put it into a percolation tank, and use 5 times the amount of 75% ethanol for percolation;

[0046] (2) Use 40% NaOH to adjust the pH value of the percolation liquid to 8.0, let it stand for 12 hours, filter, pass the filtrate through D900 decolorizing resin for decolorization, and concentrate the decolorized filtrate under reduced pressure to obtain a concentrated medicinal solution without alcohol smell;

[0047] (3) Dilute the concentrated medicinal solution with water for injection to obtain a medicinal solution with a concentration of notoginseng total saponins of 0.25 g / ml, adjust the pH value to 6.5 with 40% NaOH, pass the D101 resin column to absorb the active...

Embodiment 2

[0051] Example 2 Preparation of the powder injection for the treatment of cardiovascular and cerebrovascular diseases according to the present invention

[0052] (1) Take the dried notoginseng cut, crush it, add 3 times the amount of 80% ethanol of the crude drug, seal it, soak it at room temperature for 36 hours, put it into a percolation tank, and use 5 times the amount of 95% ethanol for percolation;

[0053](2) Use 40% NaOH to adjust the pH value of the percolation liquid to 5.0, let it stand for 48 hours, filter, and then decolorize the filtrate through the D900 decolorizing resin column, and then decolorize it with activated carbon. The decolorized filtrate is concentrated under reduced pressure to obtain a concentrated liquid without alcohol ;

[0054] (3) Dilute the concentrated medicinal solution with water for injection to obtain a medicinal solution with a concentration of notoginseng total saponins of 0.20 g / ml, adjust the pH value to 8.0 with 40% NaOH, pass the D1...

Embodiment 3

[0058] Example 3 Preparation of the powder injection for the treatment of cardiovascular and cerebrovascular diseases according to the present invention

[0059] (1) Take the dried notoginseng cut, crush it, add 5 times the amount of 70% ethanol, seal it, soak it at room temperature for 12 hours, put it into a percolation tank, and use 5 times the amount of 80% ethanol for percolation;

[0060] (2) Use 40% NaOH to adjust the pH value of the percolation liquid to 6.5, let it stand for 24 hours, filter, pass the filtrate through D900 decolorizing resin for decolorization, and concentrate the decolorized filtrate under reduced pressure to obtain a concentrated medicinal solution without alcohol smell;

[0061] (3) Dilute the concentrated medicinal solution with water for injection to obtain a medicinal solution with a concentration of Panax notoginseng total saponins of 0.50 g / ml, adjust the pH value to 7.0 with 40% NaOH, pass the D101 resin column to absorb the active ingredients...

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PUM

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Abstract

The present invention provides a kind of medicine powder for injection for treating cardiac and cerebral vascular diseases and its preparation process and application. The medicine powder for injection has effective component total arasaponin comprising ginsenoside Rg1 10.0-55.0%, ginsenoside Rb1 20.0-65.0%, arasaponin R1 2.0-45.0 %, ginsenoside Re 1.5-40.0% and ginsenoside Rd 4.0-45.0%. The present invention also provides the application of the medicine powder for injection in preparing medicine for preventing and treating apoplexy, hemiplegia, cerebral vascular disease sequelae, etc.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a powder injection (including a special solvent) for treating cardiovascular and cerebrovascular diseases and a preparation process thereof. Background technique [0002] Panax notoginseng is a perennial herb of the family Araliaceae. The preparation with total saponins of Panax notoginseng as the main active ingredient can be used clinically to treat cardiovascular and cerebrovascular diseases, stroke hemiplegia, blood stasis syndrome, cerebral embolism, central retinal vein occlusion ; Increase cerebral artery and coronary blood flow, reduce blood lipids, reduce blood viscosity, improve microcirculation, etc. [0003] At present, the commonly used preparation process of Panax notoginseng saponins is as follows: take Panax notoginseng roots, wash, infiltrate, and slice. Then put it into an extraction tank, add water to decoct and extract twice, combine the extracts, concentrate, and add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/14A61P9/10A61P25/00
Inventor 方同华王春生
Owner HEILONGJIANG ZBD PHARMA