Medicated pad for preventing and treating hysteromyoma and its preparing method
A technology for uterine fibroids and pads is applied in the field of medicinal pads for preventing and treating uterine fibroids and the field of preparation thereof, which can solve the problems of long medication time, cumbersome preparation of medicines, waste of time and energy, etc. The effect of tumor and wearing comfort
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Embodiment 1
[0032] The method of the optimal percutaneous penetration effect condition of the present invention comprises the steps:
[0033] (1) Take a rat with a body weight of 200±20g, anesthetize it with about 1.2mL of 2.5% thiocurrant sodium solution, fix the limbs, cut off the mouse hair on both sides of the midline of the abdomen with curved scissors, and then shave it with an electric shaver Net fluff. Carefully peel the skin and separate the subcutaneous fat and tissue to obtain the isolated mouse skin. Rinse several times with distilled water and normal saline, and set aside.
[0034] (2) Face the dermis side of the isolated mouse skin to the receiving pool of the diffusion pool, refer to the attachment figure 1 , Clamp it with an iron clip, inject 18ml of 20% ethanol saline solution into the receiving space through the sampling tube, so that the liquid level is just in contact with the skin. Take 0.4ml of 1% drug solution to be tested and inject it into the diffusion chamber...
Embodiment 2
[0040] The preparation method of intelligent polymer hydrogel of the present invention comprises the following steps:
[0041] (1) Preparation of hydrogel: 0.02 mol monomer N-isopropylacrylamide (NIPA) and 4×10 -4 mol of cross-linking agent N,N,-methylenebisacrylamide (BIS) was dissolved in 15ml deionized water, and CaCO with an average particle size of 800-2500 mesh was added 3 Particles, in thru N 2 Under the condition of mechanical stirring 20min, add the initiator ammonium persulfate (APS) of 0.02g, continue to pass through N 2 10min, then add 40ul accelerator tetramethylethylenediamine, continue to stir, after the viscosity of the system increases, the reactant is moved into the test tube, and the test tube is sealed to allow the reaction to proceed completely (the test tube containing the hydrogel is placed in the In a water bath at 40°C, take out the hydrogel after it shrinks evenly, rinse with deionized water to remove unreacted monomers, cut the rinsed hydrogel into...
Embodiment 3
[0053] The preparation of the drug hydrogel of the present invention comprises the following steps:
[0054] 1) Formulation (volume ratio):
[0055] Distilled water: 37%
[0056] Ethanol-Chinese medicine extract: 60%
[0057] Oleic acid: 3%
[0058] 2) Method: Put the dry gel in a certain amount of medicinal liquid, which is the extract of Rhizoma Cyperi Cyperi, Paojiang, Radix Glycyrrhizae, Radix Paeoniae Rubra, and its mass ratio is 1:2:1:1.5, soak for a day and night, take out , Wipe the moisture on the surface with filter paper, and conduct a performance test.
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