Heparin sodium production process

Abstract

The invention relates the technology of heparin sodium. The invention overcomes the defects of many procedures, big heparin sodium biological activity damage, little productivity and high residual quantity. The invention comprises the following steps: clearing raw material, extracting, flocculating and setting, ion exchanging, washing, carrying out elution, settling, dewatering and drying. The invention has the advantages of rational technology, improving quality, little active damage, little residual quantity, high purify, low cost, and good economic benefit.

Description

technical field [0001] The invention relates to a method for extracting medical heparin sodium, in particular to a production process for heparin sodium. Background technique [0002] Heparin sodium is a macromolecular compound. It is a sodium salt of aminopolysaccharide sulfate mixed with acidic mucopolysaccharides with different molecular weights from 6000 to 8000. It is a white powder, soluble in water, and not easily soluble in organic solvents such as ethanol and acetone. Heparin sodium is not only a mucopolysaccharide sulfate anticoagulant in medicine, but also has a hypolipidemic effect. Because heparin sodium is a natural substance extracted from living organisms, not a chemically synthesized product, and has no side effects, it is favored by doctors and patients in clinical use. It is widely used to prevent and treat various cerebrovascular diseases and prevent prothrombin from converting Fibrin monomers can prevent the aggregation and destruction of platelets, tre...

AI Technical Summary

Problems solved by technology

Although this process is simple and stable, the yield of crude heparin sodium obtained is low, which has a great impact on the biological activity of heparin sodium, losing 5-7% of the activity of heparin sodium, and the residual amount of protein is relatively high, so the titer is difficult to reach 90 USPu More than / mg, the quality is difficult to control and stable