Heparin sodium production process

A production process, the technology of heparin sodium, which is applied in the extraction field of medical heparin sodium, can solve the problems of heparin sodium greatly affecting the biological activity, difficult to control and stabilize the quality, and high protein residue, so as to reduce production and operation costs and balance time Fast, short equilibration time effect

Inactive Publication Date: 2006-12-13
胡世辉
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Although this process is simple and stable, the yield of crude heparin sodium obtained is low, which has a great impact on the biological activity of heparin sodium, losing 5-7% of the a

Method used

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Embodiment Construction

[0020] Fresh pig small intestines are washed to remove impurities and stored in cold storage. When the pig small intestine reaches a certain amount, take out the pig small intestine and soak in water for 6 hours, let it defrost naturally, and clean it. Then send the pig small intestine to the multi-functional stainless steel to the intestine machine for scraping. The force should be even when scraping the intestine. The scraped casing, intestine skin and intestinal mucosa should be stacked separately and cleaned up in time. The intestinal mucosa should be uniformly discharged to the storage pool to ensure the freshness of the intestinal mucosa. Then add sodium chloride and lye to the reaction pot, control the salinity at about 5%, control the alkalinity at PH=9, pour it into the intestinal mucosa, stir for 10 minutes, and keep the pH value constant. If the intestinal mucosa is pickled, it should also be diluted with water to reach the standard 0.8-1N measured by a hydrometer ...

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Abstract

The invention relates the technology of heparin sodium. The invention overcomes the defects of many procedures, big heparin sodium biological activity damage, little productivity and high residual quantity. The invention comprises the following steps: clearing raw material, extracting, flocculating and setting, ion exchanging, washing, carrying out elution, settling, dewatering and drying. The invention has the advantages of rational technology, improving quality, little active damage, little residual quantity, high purify, low cost, and good economic benefit.

Description

technical field [0001] The invention relates to a method for extracting medical heparin sodium, in particular to a production process for heparin sodium. Background technique [0002] Heparin sodium is a macromolecular compound. It is a sodium salt of aminopolysaccharide sulfate mixed with acidic mucopolysaccharides with different molecular weights from 6000 to 8000. It is a white powder, soluble in water, and not easily soluble in organic solvents such as ethanol and acetone. Heparin sodium is not only a mucopolysaccharide sulfate anticoagulant in medicine, but also has a hypolipidemic effect. Because heparin sodium is a natural substance extracted from living organisms, not a chemically synthesized product, and has no side effects, it is favored by doctors and patients in clinical use. It is widely used to prevent and treat various cerebrovascular diseases and prevent prothrombin from converting Fibrin monomers can prevent the aggregation and destruction of platelets, tre...

Claims

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Application Information

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IPC IPC(8): C08B37/10
Inventor 胡世辉
Owner 胡世辉
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