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Stent with functional nanometer drug-carried coat

A nano-drug-loading and vascular stent technology is applied in the field of prostheses in the field of medical device technology, which can solve problems such as inability to solve the problem of treatment, inability to achieve a good treatment effect, etc., and achieve the effect of convenient release and expression

Inactive Publication Date: 2006-12-27
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently used drug-eluting stents can only be loaded with a single drug
However, only using a single drug or using multiple drugs at the same time cannot solve the problem of treatment of the above-mentioned symptoms caused successively
This cannot achieve the desired therapeutic effect very well, so the multi-dimensional three-dimensional release of multiple drugs and the drug-eluting stent with programmed drug release have become a new research hotspot.

Method used

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  • Stent with functional nanometer drug-carried coat
  • Stent with functional nanometer drug-carried coat
  • Stent with functional nanometer drug-carried coat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Chitosan was dissolved in 1% (V / V) acetic acid aqueous solution to prepare 2 mg / ml chitosan acetic acid aqueous solution, and 1 ml Tween-80 was added. Weigh 10 mg of aspirin and dissolve it in the chitosan solution. Then weigh 5 mg of probucol, dissolve it in dichloromethane, add it dropwise to the above chitosan solution, and form an O / W microemulsion under stirring at room temperature. Add 10ml of 2.5mg / ml sodium tripolyphosphate solution, gel quickly, and prepare functional nanoparticles loaded with aspirin and probucol in layers.

Embodiment 2

[0048] The chitosan was dissolved in a 3% (V / V) acetic acid aqueous solution to prepare a 3.5 mg / ml chitosan acetic acid aqueous solution, and 1 ml Tween-80 was added. Weigh 25 mg of aspirin and dissolve in chitosan solution. Then weigh 10 mg probucol, dissolve it in dichloromethane, add it dropwise to the above chitosan solution, and form an O / W microemulsion under stirring at room temperature. With the volatilization of dichloromethane, the milky white gradually disappears. Add 10ml of 2.5mg / ml sodium tripolyphosphate solution, gel quickly, and prepare functional nanoparticles loaded with aspirin and probucol in layers.

Embodiment 3

[0050] Chitosan was dissolved in 5% (V / V) acetic acid aqueous solution to prepare 5 mg / ml chitosan acetic acid aqueous solution, and 1 ml Tween-80 was added. Weigh 40 mg of aspirin and dissolve in chitosan solution. Then weigh 15 mg of probucol, dissolve it in dichloromethane, add it dropwise to the above chitosan solution, and form an O / W microemulsion under stirring at room temperature. Add 10ml of 2.5mg / ml sodium tripolyphosphate solution, gel quickly, and prepare functional nanoparticles loaded with aspirin and probucol in layers.

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Abstract

Discovered is a blood vessel scaffold with functional nano drug-loaded coating, pertaining to medical apparatus technique field, comprising a tubular network scaffold and drug coating, characterized in that drugs are coated on the tubular network scaffold via functional drug-loaded nano particles. Said drug coating has a percentage composition by wt of: 58.52%-73.67% of functional drug-loaded nano paticles, 15.79%-26.82% of drug agent, and 10.54%-14.66% of additive. The disclosed scaffold can control drug release speed well, realize drug multidimensional release, so that can decrease restenosis occurrence ratio effectively after interventional treatment of blood vessel obstruction patients, decrease complications, and improve survival rate and life quality.

Description

technical field [0001] The invention relates to a prosthesis in the technical field of medical devices, in particular to a blood vessel stent with a functional nano drug-loaded coating. Background technique [0002] Since vascular stents have been used as the main means of interventional treatment of cardiovascular and peripheral vascular occlusive lesions, this technology has developed rapidly, and currently accounts for more than 80% of the treatment of such diseases. However, the biggest defect of this technique is the occurrence of vascular restenosis after stenting. From the current statistics, the incidence of restenosis after stenting is 15%-30%. Cardiovascular pharmacology studies have found that a variety of drugs can produce significant inhibitory effects on vascular intima and smooth muscle cells in vitro, but the effect of systemic drugs is not good. The reason may be related to the low blood drug concentration in the systemic circulation. Medication and its mai...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61K31/337A61K31/10A61K31/436A61K31/616A61M31/00A61F2/82
Inventor 万锕俊张悦粤李慧丽
Owner SHANGHAI JIAO TONG UNIV
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