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Mycoporin vaginal soft capsule and its preparing method

A clotrimazole and soft capsule technology, applied in the field of clotrimazole vaginal soft capsules and preparation thereof, can solve the problems of slow onset of clotrimazole suppository, inconvenient use and the like

Inactive Publication Date: 2007-01-24
赵宗平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the clinical response of clotrimazole suppositories is slow; clotrimazole film and clotrimazole cream are inconvenient to use in gynecology

Method used

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  • Mycoporin vaginal soft capsule and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Component Quantity (g / granule)

[0088] Liquid medicine: clotrimazole 0.15

[0089] White Vaseline 0.82

[0090] Liquid paraffin 1.22

[0091] Glue: Gelatin 0.350

[0092] Glycerin 0.140

[0093] Distilled water 0.350

[0094] Titanium dioxide 0.01

[0095] Ethyl p-hydroxybenzoate 0.0007

[0096] Preparation:

[0097] Heat white petrolatum and liquid paraffin and fully stir, then cool naturally, add clotrimazole fine powder, stir and pass through a colloid mill to mix evenly, set aside.

[0098] Soak and swell the gelatin in distilled water in the glue tank, add glycerin, titanium dioxide, and ethyl p-hydroxybenzoate, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to Measure the viscosity at 70-80°C to be 28,000-32,000 millipoise, put it into a temperature-adjustable rubber stabilization barrel, pour the prepared medicinal solution into the medici...

Embodiment 2

[0100] Component Quantity (g / granule)

[0101] Liquid medicine: Clotrimazole 0.3

[0102] Vaseline 1.2

[0103] Liquid paraffin 1.5

[0104] Glue: Gelatin 0.5

[0105] Glycerin 0.27

[0106] Distilled water 0.5

[0107] Titanium dioxide 0.05

[0108] Methylparaben 0.003

[0109] Preparation:

[0110] Heat white petrolatum and liquid paraffin and fully stir, then cool naturally, add clotrimazole fine powder, stir and pass through a colloid mill to mix evenly, set aside.

[0111] Soak and swell the gelatin in distilled water in the glue tank, add glycerin, titanium dioxide, and methyl p-hydroxybenzoate, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to Measure the viscosity at 70-80°C to be 28,000-32,000 millipoise, put it into a temperature-adjustable rubber stabilization barrel, pour the prepared medicinal solution into the medicinal liquid bucket, press...

Embodiment 3

[0113]Component Quantity (g / granule)

[0114] Liquid medicine: clotrimazole 0.05

[0115] Vaseline 0.4

[0116] Solid paraffin 0.4

[0117] Glue: Gelatin 0.2

[0118] Glycerin 0.1

[0119] Distilled water 0.2

[0120] Titanium dioxide 0.001

[0121] Clove oil 0.0001

[0122] Preparation:

[0123] First melt the solid paraffin at 50°C, then fully stir with the heated vaseline, then cool naturally, add clotrimazole fine powder, stir and pass through a colloid mill to mix evenly, and set aside.

[0124] Soak and swell the gelatin in distilled water first in the glue tank, add glycerin, titanium dioxide, and clove oil, heat and stir to make it melt into uniform gelatin, remove the bubbles in the glue under reduced pressure, and then concentrate to 70-80 The measured viscosity at ℃ is 28000-32000 millipoise, put it into a temperature-adjustable plastic barrel, pour the prepared medicine solution into the medicine solution bucket, press th...

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Abstract

The present invention relates to soft mycosporin capsule for vagina and its preparation process. Each of soft mycosporin capsules contains mycosporin in 50-300 mg and medicinal supplementary material vaseline and paraffin, and the capsule shell contains gelatin in 10 weight portions and glycerin in 4.0-5.5 weight portions. The preparation process includes the steps of dissolving gelatin in water and adding glycerin and proper amount of preservative, vacuum deairing, mixing mycosporin and medicinal supplementary material, and pressing into soft capsule. Compared with available mycosporin preparation forms, the soft mycosporin capsule has the advantages of stable quality, convenient carrying and administration, and fast leaching of the effective components.

Description

technical field [0001] The invention relates to a clotrimazole vaginal soft capsule and a preparation method thereof. Background technique [0002] According to the incomplete statistics of the World Health Organization, in recent years, the incidence of gynecological diseases among women has reached more than 65%, forming an important group in the sub-health group. Thus driving the development of the global gynecological drug market. In my country, the incidence of gynecological diseases in women of childbearing age is about 70%, and many women will be disturbed by urinary system infection in varying degrees, seriously affecting normal work and life. [0003] Candida vaginitis is a common gynecological disease caused by Candida albicans infection. The clinical manifestations are mainly vulvar itching and leucorrhea that is white and thick like bean dregs. The incidence of this disease is second only to trichomonas vaginitis. The most suitable pH value for the reproducti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K9/48A61P15/02
Inventor 赵宗平
Owner 赵宗平
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