Preparation method of 2-bromo-2-nitro-1,3-propylene glycol

Abstract

The present invention relates to a preparation method of 2-bromo-2-nitro-1,3-propanediol. Said method includes the following steps: adding nitromethane, bromine and water into a reactor, slowly adding sodium hydroxide aqueous solution, stirring for 0.5-2hr, introducing chlorine gas, stirring to make reaction at 0-70deg.C to obtain nitrobromoform, then stirring the obtained nitrobromoform, formaldehyde and nitromethane for 0.5-2hr, slowly adding aqueous solution of inorganic alkali catalyst at 60deg.C, making reaction for 0.5-2hr at 0-60deg.C, cooling, crystallizing, filtering and drying so as to obtain 2-bromo-3-nitro-1,3-propanediol.

Description

technical field

[0001] The invention belongs to the field of chemical synthesis and relates to a preparation method of 2-bromo-2-nitro-1,3-propanediol (bronopol). Background technique

[0002] The molecular formula of 2-bromo-2-nitro-1,3-propanediol (bronopol) is C 3 h 6 BrNO 4 , with a molecular weight of 200.0. In 1964, it was developed by Boot Co. Ltd (now AgEvo GmbH) as a cosmetic preservative and medicine, and later as an agricultural fungicide. In 1990, it was developed as a rice seed treatment agent in my country to prevent and control rice spoilage. Seedling disease, used as a cotton seed treatment agent to prevent and control cotton black arm disease or bacterial scab blight caused by cabbage black rot and yellow stem disease, has special effects, and has no phytotoxicity to cotton. It can also be used as an industrial fungicide, such as a fungicide for cooling towers. The structural formula of bronopol is as follows:

[0003]

[0004] German patent DE1954173...

Images