Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the direction of drug combination, testing of drug preparations, pharmaceutical formulations, etc., can solve the problems of unsatisfactory efficacy for acute and severe patients, small selection of drugs for doctors and patients, and long course of drug treatment, so as to protect ischemia Myocardium, easy to use and carry, good effect on ischemic myocardium

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application 200410040845.X discloses Compound Guiqi Injection and its preparation method. The product is composed of Panax notoginseng saponins, angelica, and astragalus, and is used to treat blood deficiency syndrome, chest obstruction and heart pain syndrome, stroke and stroke sequelae, and blood stasis disease However, the invention has a single dosage form, and the selectivity of doctors and patients is small. At the same time, the medicine is a pure Chinese medicine prescription, and the course of treatment is long, so the effect on acute and severe patients is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: prepare Angelica sinensis extract: get 10 parts of Angelica sinensis (part is: kilogram or gram)

[0023] Take Angelica sinensis, crush it into a coarse powder that passes through a 10-mesh sieve, add 8 times of water to decoct three times, combine the decoction, filter, and when the filtrate is concentrated to 60°C, the relative density is 1.05-1.15, and ethanol is added to make the alcohol content reach 70%, refrigerated overnight, filtered, and when the filtrate recovered ethanol to 60°C, the relative density was measured to be 1.05 to 1.15. Added 2 times the weight and volume of the medicinal materials to dissolve, filtered, and the filtrate was passed through a ZTC-1 macroporous adsorption resin column. Rinse the resin column with resin volume water, then desorb with 25% ethanol, collect the 25% ethanol desorption solution, recycle the ethanol, dry, and obtain the Angelica sinensis extract.

Embodiment 2

[0024] Embodiment 2: prepare Angelica sinensis extract: Angelica sinensis 1000 parts (kg or gram)

[0025] Take Angelica sinensis, crush it into a coarse powder that passes through a 10-mesh sieve, heat and reflux extract twice with 70% ethanol equivalent to 8 times the amount of medicinal materials, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate and concentrate it into a thick paste , to obtain the crude extract of Angelica sinensis.

Embodiment 3

[0026]Embodiment 3: prepare Angelica sinensis extract: Angelica sinensis 5000 parts (kg or gram)

[0027] Take angelica, crush it into coarse powder, add 8 times the amount of water to decoct 3 times, the first time for 1 hour, the third time for 0.5 hours, filter, the filtrate is concentrated to a relative density of 1.15-1.20 (65°C), let it cool, Add ethanol to make the alcohol content 70%, let it stand, refrigerate, overnight, filter, precipitate I for later use, reclaim ethanol from the filtrate and concentrate to a relative density of 1.16 (65°C), let it cool, add ethanol to make the alcohol content reach 85% %, refrigerate, overnight, filter, precipitate II for later use, recover ethanol from the filtrate, dry to obtain dry cream I, add water to dissolve precipitates I and II, add clarifier to the water to obtain clarified liquid, keep warm at 70°C, and concentrate the supernatant to obtain thick paste II, dry paste I and II, that is the extract of Angelica sinensis.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from Chinese angelica root or its extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] At present, cardiovascular and cerebrovascular diseases have become the most important disease that affects the health of residents, and the number one killer that endangers human health, showing a worldwide distribution. In China, there are about 2.6 million people every year, and about 7,000 people die of cardiovascular and cerebrovascular diseases every day. The pressure from work, society, and life in modern society, coupled with irregular life, unscientific diet, and lack of exercise, have contributed to the increasing incidence of cardiovascular and cerebrovascular diseases among young and middle-aged people aged 30 to 40. The onset population tends to be younger, and the age span o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K9/00A61P9/10A61P7/02G01N33/15A61K31/4164
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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