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Nano antibiotic antiviral condom

A condom, anti-virus technology, applied in male contraceptives, peptide/protein components, medical preparations containing active ingredients, etc., to achieve good sterilization effect

Inactive Publication Date: 2007-02-28
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

IFN has no virus specificity, and IFN induced by a virus is also effective for its virus, but it is species specific, and IFN produced by mice is ineffective in humans

Method used

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  • Nano antibiotic antiviral condom
  • Nano antibiotic antiviral condom
  • Nano antibiotic antiviral condom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Grafting of interferon

[0021] 1. Add IFN-α (30 μg, 0.002 μmol) to 3 ml of N-succinimide (61.5 μg, 0.2 μmol) in dimethylamide DMF / PBS (volume ratio 4:1) solution, and stir the reaction in an ice bath After 48h (4°C), after the synthesis, the azidophenyl-derived IFN-α was purified by ultrafiltration membrane (milipore moleculecut II, 10k Na).

[0022] 2. Before photofixation, the polyurethane condom was cut into a circular piece with a diameter of 10 mm and placed on a 24-well tissue culture plate, and then the following treatment was performed: respectively, the photoactive IFN-α was treated with six concentrations (0.01 μg, 0.025 μg, 0.05μg, 0.075μg, 0.1μg, 0.25μg) into the 24-well tissue culture plate, after adding the drug, put each plate in the refrigerator, freeze-dry (4°C), and then put it under the ultraviolet lamp (15W) at 2cm After irradiating for 20 minutes, the active IFN was immobilized on the PU material by using the very active azide group. Aft...

Embodiment 2

[0023] Example 2 Electron microscope observation of the morphology of photoimmobilized IFN-α

[0024] A, B, C, and D of Fig. 1 are respectively the polyurethane and the polyurethane surface after grafting active IFN-α observed under the field emission scanning electron microscope. After that, it can be seen that the interferon forms a uniformly distributed and orderly protein layer on the surface of the polyurethane, and there is also a small amount of agglomeration as shown in Figure 4D, because the interferon molecule is not large. Take Figure 1D as an example, observe at 20,000 times, use Imagepro plus5.0 to analyze the picture under the electron microscope, the parameters are as follows:

[0025] Typical object area in:

[0026] Stats

[0027] The computer scanned and analyzed the 10,406 objects in Figure 1D. There are 390 particles that conform to IFN. The average particle size of the particles is between 28.7nm and 109.9nm, and the average particle si...

Embodiment 3

[0028] Example 3 Observation of the morphology of IFN-α by laser scanning confocal microscope (CSLM)

[0029] Two channels were used for confocal laser scanning microscopy observation, the first channel was used to observe the stained FITC IFN-α, the second channel was projected to show the surface of polyurethane material, and the third channel was superimposed. The interferon on the surface of the material was sliced ​​six times to obtain Figure 2.

[0030] FITC is extremely easy to quench, but it can specifically stain IFN-α protein. It can be seen that IFN molecules are not simply attached to the surface of the material, but are firmly grafted on the surface of polyurethane and have biological activity.

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Abstract

The invention discloses a nanometer graded antibiotic antiviral condom, which is characterized by the following: grafting interferon on the condom, improving sterilizing activity from 2.1% to 6.3%.

Description

technical field [0001] The invention relates to a condom, in particular to a nanoscale antibacterial and antiviral condom. Background technique [0002] Condoms are the most commonly used contraceptives in the world, and hundreds of millions are consumed every year. Condoms do no harm to the human body. Compared with other contraceptives, they have many advantages. Since the 1990s, a A new type of polyurethane condom has been developed, which not only has the advantages of rubber condoms, such as similar slippage rate and breakage rate, but also is suitable for people who are sensitive to rubber. Not only that, polyurethane condoms can be made thinner, giving people a Better feeling. [0003] Cervicitis is a common gynecological disease, mainly divided into gonorrhea cervicitis and non-gonococcus cervicitis, gonorrhea cervicitis is mainly caused by diplococcus gonorrhoeae, Staphylococcus aureus and hemolytic streptococcus, non-gonococcal cervicitis It is mainly caused by v...

Claims

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Application Information

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IPC IPC(8): A61F6/04A61K38/19
Inventor 关燕清彭长连李岳川
Owner SOUTH CHINA NORMAL UNIVERSITY
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