Process for preparing notoginsen triterpenes

A technology of Panax notoginseng total saponins and Panax notoginseng is applied in the field of preparation of Panax notoginseng total saponins and achieves the effects of stable quality, less impurities and high purity

Inactive Publication Date: 2007-02-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the macroporous resin method for extracting Panax notoginseng saponins has many ad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]Take notoginseng decoction pieces, crush them, soak in water with 3 times the weight of the crude drug, adjust the pH to 4.0 with acid, add 10 U of cellulase per gram of crude drug, stir well, put in a water bath at 40°C for 3 hours, and extract the solution for later use; Add water to the residue after extraction and reflux extraction twice at 90°C. The first time is 7 times the weight of the crude drug, and the second time is 6 times the weight of the crude drug. Each time for 2 hours, combine the extracts before and after, and discard the residue; The extract is concentrated under reduced pressure at 70°C and a vacuum of 0.06Mpa-0.07Mpa to 1 times the volume of the medicinal material, and then filtered; the filtrate is diluted with water to 2 times the volume of the medicinal material, centrifuged, and the clear liquid is taken; D-941 ion exchange resin (Shandong Lukang Resin Branch Factory) column at a flow rate of twice the column volume, eluted with 2.5 times the vo...

Embodiment 2

[0050] Take notoginseng decoction pieces, crush them, soak in water with 3 times the weight of the crude drug, adjust the pH to 4.0 with acid, add 10 U of cellulase per gram of crude drug, stir well, put in a water bath at 40°C for 3 hours, and extract the solution for later use; Add water to the residue after extraction and reflux extraction twice at 90°C. The first time is 7 times the weight of the crude drug, and the second time is 6 times the weight of the crude drug. Each time for 2 hours, combine the extracts before and after, and discard the residue; The extract is concentrated under reduced pressure at 70°C and a vacuum of 0.06Mpa-0.07Mpa to 1.5 times the volume of the medicinal material, and filtered; the filtrate is diluted with water to 2 times the volume of the medicinal material, centrifuged, and the clear liquid is taken; the clear liquid is 0.8 times per hour. D-941 ion exchange resin (Shandong Lukang Resin Branch Factory) column at a flow rate of twice the colum...

Embodiment 3

[0052] Take notoginseng decoction pieces, crush them, soak in water with 3.5 times the weight of the crude drug, adjust the pH to 4.5 with acid, add 12 U of cellulase per gram of crude drug, stir well, put in a water bath at 40°C for 3 hours, and extract the solution for later use; After the extraction, the residue was added with 75% ethanol and refluxed twice at 90°C. The first time was 75% ethanol of 7 times the weight of the crude drug, and the second time was 6 times the amount of 75% ethanol. Each time for 2 hours, the combined extraction liquid, discard the residue; the extract is concentrated under reduced pressure at 70°C and a vacuum of 0.06Mpa-0.07Mpa to the volume of the medicinal material to 2 times the volume of the medicinal material, and filtered; the filtrate is loaded on D-941 at a flow rate of 1 column volume per hour Ion-exchange resin (Shandong Lukang Resin Branch Factory) column, eluted with 60% ethanol with 3 times the volume of medicinal materials, and th...

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PUM

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Abstract

The invention discloses a process for preparing Notoginsen triterpenes injection, which comprises steps of immersing notoginseng with water, charging cellulose for enzymolysis, watering extracted muck or charging 10-90% of ethanol for extraction, concentrating the extract and passing through anion exchange resin column, concentrating eluent into concrete through decompressing, finally drying.

Description

technical field [0001] The invention relates to a preparation method of Panax notoginseng saponins. Background technique [0002] Panax notoginseng has the effects of nourishing and strengthening, stopping bleeding, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and is widely used clinically. Panax notoginseng contains saponins, flavonoids, amino acids, polysaccharides, fatty acids, peptides and other components, among which dammarane-type tetracyclic triterpenoid saponins are considered to be the main physiologically active components of panax notoginseng. There are many methods for extracting saponins from Panax notoginseng, such as cold soaking, percolation, decoction and alcohol precipitation, etc. Traditionally, the method of n-butanol extraction is often used. The organic solvents such as n-butanol used in this method are highly toxic, cumbersome to operate, low in yield, and high in cost. Nowadays, people mostly use the ...

Claims

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Application Information

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IPC IPC(8): A61K36/258C12P19/56A61K31/704A61P29/00A61P7/04A61P9/10
Inventor 魏峰李德坤
Owner TIANJIN TASLY PHARMA CO LTD
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