Anti-cancer slow release injection comprising anticancer antibiotics

Abstract

Disclosed is an anticancer slow release antibiotic agent which comprises slow release microspheres and dissolvent, wherein the slow release microballoons comprise anti-cancer active constituents and slow release auxiliary materials, the dissolvent being conventional dissolvent or specific dissolvent containing suspension adjuvant. The anticancer active constituents include anticancer antibiotics and / or anticancer antibiotic synergistic agent, the anticancer antibiotic synergistic agent is selected from anti-taxone, alkyl agent and / or plant alkaloids, the slow release auxiliary materials are selected from Polifeprosan, di-aliphatic acid and sebacylic acid copolymer, poly(erucic aciddipolymer-sebacylic acid), poly(fumaric acid-sebacylic acid), ethylene-vinylacetate copolymer, the viscosity of the suspension adjuvant is 100-3000cp (at 25-30 deg C), and is selected from sodium carboxymethylcellulose. The slow release microspheres can also be prepared into slow release implanting agent for lowering down the whole body toxicity reaction of the anti-cancer medicament, selectively increasing the tumor local medicinal concentration, and improving the treatment effect of the non-operative treatment methods such as chemotherapy.

Description

(1) Technical field

[0001] The invention relates to an anti-cancer sustained-release injection and a preparation method thereof, belonging to the technical field of medicines. Specifically, the present invention provides an anticancer drug slow-release preparation containing anticancer antibiotics and / or anticancer antibiotic synergists, mainly slow-release injections and slow-release implants. (2) Background technology

[0002] As a class of commonly used chemotherapeutic drugs, anticancer antibiotics have been widely used in the treatment of various malignant tumors, and the effect is more obvious. However, its obvious systemic toxicity greatly limits the application of this drug. Not only that, blood vessels, connective tissue, matrix proteins, fibrin, and collagen in the tumor stroma not only provide scaffolds and essential nutrients for the growth of tumor cells, but also affect the effect of chemotherapy drugs on the surrounding tumor and tumor tissue. Penetration an...