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Preparation method of traditional medicine preparation for treating women's menoxenia

A technology of irregular menstruation and traditional Chinese medicine preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc. It can solve the problems of slow disintegration speed, low bioavailability, long working hours, etc., and achieve rapid onset of effect , the dosage is small, and the process route is simple

Inactive Publication Date: 2007-03-14
浙江省中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say, the prescription was originally used for sugar-coated tablets in clinical practice, and the ingredients in the prescription, such as Muxiang, Ligusticum chuanxiong, Corydalis Corydalis and some Chinese angelica, are used as raw powder, and the process of coating sugar-coating requires a long time in actual production, and consumes a lot of materials. The weight of the layer increases too much (the tablet weight is increased by 50-100%), and the sugar-coated tablet obtained by this preparation method has the disadvantages of large dosage (three times a day, 5 tablets at a time), slow disintegration speed, and low bioavailability. Affect the promotion and use of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Take 83g Muxiang, 125g Wuyao, 125g Atractylodes Rhizoma Atractylodes Rhizome, 83g Corydalis Corydalis made from vinegar, 250g Angelica sinensis, 250g Cyperus cyperi, 42g Evodia rutaecarpa made from licorice water, 250g Bawei from Eupatorium and pulverize into coarse powder, and use percolation method to 70 % ethanol as the solvent, after soaking for 24 hours, carry out percolation, collect 8000ml of percolation liquid, recover ethanol under reduced pressure, concentrate to relative density 1.05~1.10, the concentrated solution measured at 65°C, and set aside;

[0019] (2) Take 83g Chuanxiong, 167g rehmannia glutinosa, 167g red peony root, 125g safflower, 250g salvia miltiorrhiza, 250g Caulis Spatholobus, 333g dodder seed Qiwei, decoct twice for 1.5 hours each time, combine the liquid medicines, filter and concentrate To a relative density of 1.01-1.02, measure at 65°C, centrifuge at high speed, add the above concentrate, continue to concentrate to a relative density o...

Embodiment 2

[0022] (1) Take 75g of Muxiang, 113g of Wuyao, 113g of Atractylodes Rhizoma Atractylodes Rhizome, 75g of Corydalis Corydalis made from vinegar, 225g of Angelica sinensis, 22g of Cyperus cyperi, 38g of Evodia rutaecarpa made from licorice water, and 225g of Eupatorium bawei. % ethanol as the solvent, after immersion for 18 hours, carry out percolation, collect 7500ml of percolation liquid, recover ethanol under reduced pressure, concentrate to relative density 1.05~1.10, the concentrated solution measured at 62 ℃, set aside;

[0023] (2) Take 75g of Rhizoma Chuanxiong, 150g of Rehmannia glutinosa, 150g of Radix Paeoniae Rubra, 113g of Safflower, 225g of Salvia Miltiorrhiza, 225g of Caulis Spatholobus, and 300g of Cuscuta chinensis, add water and decoct twice for 1.5 hours each time, combine the liquid medicines, filter and concentrate To a relative density of 1.01-1.02, measure at 62°C, centrifuge at high speed, add the above-mentioned concentrated solution, continue to concentr...

Embodiment 3

[0026] (1) Take 91g of Muxiang, 138g of Wuyao, 138g of Atractylodes Rhizoma Atractylodes Rhizome, 91g of Corydalis Corydalis made from vinegar, 275g of Angelica sinensis, 275g of Cyperus cyperi, 46g of Evodia rutaecarpa made from licorice water, and 275g of Eupatorium Bawei, and pulverize them into coarse powder, and use percolation method with 75 % ethanol is the solvent, after soaking for 30 hours, carry out percolation, collect 8500ml of percolation liquid, recover ethanol under reduced pressure, concentrate to relative density 1.05~1.10, the concentrated solution measured at 68 ℃, set aside;

[0027] (2) Take 91g of Rhizoma Chuanxiong, 184g of Rehmannia glutinosa, 184g of Radix Paeoniae Rubra, 138g of Safflower, 275g of Salvia Miltiorrhiza, 275g of Caulis Spatholobus, and 366g of Cuscuta chinensis, decoct twice for 1.5 hours each time, combine the liquid medicines, filter and concentrate To a relative density of 1.01-1.02, measure at 68°C, centrifuge at high speed, add the ...

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PUM

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Abstract

The invention discloses a preparation method of Chinese drugs pharmaceutics for the treatment of women's menstrual disorders. Steps are as follows: (1) recipe the aucklandiae, combined spicebush root, atractylodes macrocephala, corydalis processed with vinegar, Chinese angelica, nutgrass galingale rhizome, rutaecarpine prepared in licorice water, eupatorium and crush them into coarse powder, percolate with 70% ethanol solvent as dissolvent using the percolation method and collect the percolate, recover the alcohol with decompression, concentrate the percolate and the concentrated solution is reserved; (2) recipe Chuanxiong, prepared rehmannia root, paeoniae radix, safflower, salvia miltiorrhiza, caulis millettiae, cuscuta seed and add water to boil twice, put the physic liquor together, filt and concentrate, centrifugate on high-speed, add the concentrated solution above mentioned, continue to concentrate, reserve; (3) recipe the above mentioned extract by adding lactose, sucrose powder, dextrin, put them into the boiling granulating machine for further granulating and fiat into drug granules.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine preparation for treating irregular menstruation of women. Background technique [0002] Irregular menstruation and dysmenorrhea are common and frequently-occurring diseases in gynecology, which bring a lot of inconvenience and troubles to women in daily life and work. The etiology and pathogenesis are mainly the injury of the seven emotions or the six evils caused by exogenous factors, or congenital deficiency of kidney qi, prolific fatigue, overwork, damage to visceral qi, dysfunction of kidney, liver and spleen, and imbalance of qi and blood, resulting in damage to the Chong and Ren channels And morbidity, with stagnation of QI and blood stasis as many. The patient is often worried and depressed, the qi is not ventilated, the blood is qi stagnation, and the chongren is blocked. Irregula...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00
Inventor 王溶溶陈丹菲金祖汉杨苏蓓潘建明
Owner 浙江省中药研究所有限公司
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