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Preparation of gardenia jasminoides by macroporous adsorbing resin

A technology of gardenia extract and pore adsorption, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problems of unreasonable use of gardenia and waste of resources, etc., so as to reduce preparation costs and prolong Service life, technically reasonable effect

Inactive Publication Date: 2010-05-19
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But every year tens of thousands of tons of gardenias in the whole country are not rationally utilized, wasting precious resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Use gardenia produced in Fujian as the raw material, wash fresh gardenia with water, dry (air-dried, oven-dried or sun-dried), pulverize, and pass through a 20-30 mesh sieve to obtain gardenia powder, and put 2.9kg of gardenia powder into the extraction tank 40% methanol-acetone (1:1) aqueous solution with 10 times the dry weight (W / W) of gardenia powder, refluxed extraction at 68°C for 3 times, each time for 2 hours, combined extracts, filtered, Under the conditions of -0.06~-0.095MPa and 50~80°C, the filtrate is recovered under reduced pressure to recover the solvent, and then concentrated in vacuo to obtain the gardenia extract. After determination, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 93.2%, 96.3% and 93.1%, respectively.

[0036] Next, the crude extract of Gardenia jasminoides is first added with an appropriate amount of water and stirred into a suspension to make the specific gravity of the suspension reach 1.0...

Embodiment 2

[0039] Put 2.6 kg of gardenia powder of 20 to 30 meshes into an extraction tank, extract 2 times at 50°C with 25% aqueous methanol solution of 15 times the dry weight (W / W) of gardenia powder, each time for 3 hours, and combine The extract is filtered, and the filtrate is recovered under reduced pressure under the conditions of -0.06 to -0.095MPa and 50 to 80°C, and concentrated in a vacuum to form a gardenia extract. After determination, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 92.3%, 92.8% and 91.8%, respectively.

[0040] Stir the gardenia crude extract with appropriate amount of water to form a suspension, so that the specific gravity of the suspension reaches 1.12, and then use a polyvinylidene fluoride membrane with a molecular weight cut-off of 30,000 to perform membrane separation and removal of impurities at 0.60 MPa to remove proteins, polysaccharides and other After the macromolecular impurities are removed, the gard...

Embodiment 3

[0043] Put 2.7 kg of gardenia powder of 20 to 30 meshes into an extraction tank, use 75% aqueous methanol solution of 5 times the dry weight (W / W) of gardenia powder, extract under reflux at 80°C for 1 hour, filter, and the filtrate is in- Under the conditions of 0.06~-0.095MPa and 50~80°C, the solvent is recovered under reduced pressure, and the gardenia extract is obtained by vacuum concentration. After determination, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 95.6%, 95.0% and 93.5%, respectively.

[0044] Stir the gardenia crude extract with appropriate amount of water to form a suspension, so that the specific gravity of the suspension reaches 1.03, and then use an inorganic ceramic membrane with a membrane pore size of 0.22 μm to perform membrane separation and removal of impurities at 0.25 MPa to remove macromolecules such as proteins and polysaccharides After removing the impurities, the Gardenia jasmine extract after memb...

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Abstract

A process for preparing the extract from capejasmine fruit by use of macroreticular adsorption resin includes such steps as extracting in hydrophilic solvent to obtain coarse extract, membrane separation for removing impurities, adding water to become suspension, adsorbing by macroreticular resin, water washing for removing polar impurities, eluting with the aqueous solution of hydrophilic solvent, vacuum recovery of solvent, and vacuum concentrating.

Description

technical field [0001] The invention relates to a green chemical preparation method for separating and purifying medicinal active ingredients from plants, and more particularly relates to a method for preparing gardenia jasmine extract by using a macroporous adsorption resin. Background technique [0002] Gardenia is the fruit of the evergreen shrub Gardenia (Gardenia) Rubiaceae (Rubiaceae), which is a large amount of traditional Chinese medicinal materials in China. The main medicinal ingredients of Lingling Injection, Longdan Xiegan Tablets and Yindan Pinggan Capsules are the first-choice drugs for the clinical treatment of jaundice hepatitis in traditional Chinese medicine and the raw materials for extracting natural pigments from gardenia. They are abundant in Fujian, Zhejiang, Jiangxi, Huizhou, Mountainous areas in Hunan and other provinces. [0003] Gardenia has been recorded in famous medical works of all dynasties from "Compendium of Materia Medica" to "Chinese Phar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P1/16A61P31/14A61K131/00
Inventor 陈剑锋郭养浩陈浩
Owner FUZHOU UNIV
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