Medicinal slow release agent for treating rabbit infections rhinitis and its preparing method

A technology of infectious and sustained-release agents, which is applied in the field of sustained-release agents for the prevention and treatment of infectious rhinitis in rabbits and its preparation, can solve the problems of difficulty in achieving therapeutic effects, no long-term sustained bactericidal effect, and unstable effects, and achieve good results. Effects of treatment and prevention, saving on prevention and treatment drug expenses, and ease of popularization and application

Inactive Publication Date: 2007-04-11
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the present inventor adopts azithromycin at first with 40mg/kg body weight mixing material oral administration mode, feeds for 5 days, stops 10 days, test 2 months, observation has done preparatory control to rabbit Bordetella and Pasteurella The effect test shows that the drug has a good therapeutic effect on Bordetella rabbits and Pasteurella; however, it is also found that there are the following problems: First, although the oral administration of drug mixture is convenient for large-scale breeding farms, it cannot Due to the reduction of feed intake due to the illness of the rabbits, especially the severe disease rabbits even stop eating the feed, this just does not reach the requirement of taking an effective dose of medicine, and it is difficult to achieve the therapeutic effec

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: (prevention and treatment of rabbit infectious rhinitis drug sustained-release preparation method 1)

[0025] (1) Add 50 grams of powdered Bordetella and Pasteurella agent azithromycin into 400 ml of absolute ethanol, and stir until the medicine is completely dissolved into a transparent liquid;

[0026] (2) Add 75 grams of powdered β-cyclodextrin into 50 milliliters of distilled water, and grind for 20 minutes to form a paste;

[0027] (3) Pour the azithromycin solution into the pasty β-cyclodextrin, stir for 30 minutes, put it at 30-40°C until dry, grind it, and sieve it with 80-90 mesh to obtain 124.8 grams of powdered sustained-release agent;

[0028] (4) Divide the powdered sustained-release agent into 2 g / bottles, and seal to form a powdered sustained-release agent product.

[0029] (5) Add 20ml of normal saline to each bottle of powdered sustained-release preparation, shake until the drug is completely wetted into a suspension, which is the sustain...

Embodiment 2

[0030] Embodiment 2: (prevention and treatment of rabbit infectious rhinitis drug sustained-release preparation method 2)

[0031] (1) Add 50 grams of powdered Bordetella and Pasteurella agent azithromycin into 350 milliliters of absolute ethanol, and stir until the medicine is completely dissolved into a transparent liquid;

[0032] (2) Add 50 grams of powdered β-cyclodextrin into 25 milliliters of distilled water, and grind for 30 minutes to form a paste;

[0033] (3) Pour the azithromycin solution into the pasty β-cyclodextrin, stir for 40 minutes, place it at 30-40°C until dry, grind it, and sieve it with 80-90 mesh to obtain 99.8 grams of powdered sustained-release agent;

[0034] (4) subpack the powdered sustained-release agent by 1.6 g / bottle, and seal it to form a powdered sustained-release agent product;

[0035] (5) Add 20ml of normal saline to each bottle of powdered sustained-release preparation, shake until the drug is completely wetted into a suspension, which i...

Embodiment 3

[0036] Embodiment 3: (prevention and treatment of rabbit infectious rhinitis drug slow-release preparation method 3)

[0037] (1) Add 50 grams of powdered Bordetella and Pasteurella agent azithromycin into 450 milliliters of absolute ethanol, and stir until the medicine is completely dissolved into a transparent liquid;

[0038] (2) Add 100 grams of powdered β-cyclodextrin into 150 milliliters of distilled water, and grind for 40 minutes to form a paste;

[0039] (3) Pour the azithromycin solution into the pasty β-cyclodextrin, stir for 60 minutes, put it at 30-40°C until dry, grind it, and sieve it with 80-90 mesh to obtain 149.7 grams of powdered sustained-release agent;

[0040] (4) subpack the powdered sustained-release agent by 2.4 g / bottle, and seal it to form a powdered sustained-release agent product;

[0041] (5) Add 20ml of normal saline to each bottle of powdered sustained-release preparation, shake until the drug is completely wetted into a suspension, which is th...

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PUM

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Abstract

The invention discloses a slow-released preparation in treatment and prevention for rabbit malignant rhinitis and means of making thereof, belonging to the technical field for treating and prevention of livestock epidemic disease. Said preparation consists of Azithromycin and beta cyclodextrin as materials and prepares in accordance with part by weight; preparation means is, first mixing and dissolving Azithromycin and anhydrous alcohol in accordance with weight-to-volume ratio : 1g.: 7-9 ml.; mixing and grinding into paste beta cyclodextrin and distilled water in accordance with weight-to-volume ratio : 1g.: 0.5-1.5ml.; thereafter mixing, compounding, drying, grinding both described hereinabove to obtain slow-released powder; being prepared into injection when applying.

Description

technical field [0001] The invention relates to the technical field of livestock epidemic prevention and control, in particular to a drug slow-release agent for the prevention and treatment of rabbit infectious rhinitis caused by Bordetella and Pasteurella infection and a preparation method thereof. Background technique [0002] Infectious rhinitis in rabbits is caused by the mixture of Pasteurella and Bordetella. It is easy to be mixed with coccidiosis in young rabbits, and it is easy to be mixed with Staphylococcus after adult rabbits. Rabbit infectious rhinitis is one of the diseases that often occur in rabbits, and the incidence rate can reach 20% to 70%. Factors that cause stress may include cold weather, pregnancy, complications, and experimental stress. The disease is common in large-scale farms, and it is a headache bacterial infectious disease; it is generally sporadic or endemic, and occurs all year round. The incubation period of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61K9/14A61K47/40A61P11/02A61P31/04
Inventor 张雪娟项美华付媛卢福庄杨玉焕冯尚连程菊芬徐海风
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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