Medicinal slow release agent for treating rabbit infections rhinitis and its preparing method

Abstract

The invention discloses a slow-released preparation in treatment and prevention for rabbit malignant rhinitis and means of making thereof, belonging to the technical field for treating and prevention of livestock epidemic disease. Said preparation consists of Azithromycin and beta cyclodextrin as materials and prepares in accordance with part by weight; preparation means is, first mixing and dissolving Azithromycin and anhydrous alcohol in accordance with weight-to-volume ratio : 1g.: 7-9 ml.; mixing and grinding into paste beta cyclodextrin and distilled water in accordance with weight-to-volume ratio : 1g.: 0.5-1.5ml.; thereafter mixing, compounding, drying, grinding both described hereinabove to obtain slow-released powder; being prepared into injection when applying.

Description

technical field [0001] The invention relates to the technical field of livestock epidemic prevention and control, in particular to a drug slow-release agent for the prevention and treatment of rabbit infectious rhinitis caused by Bordetella and Pasteurella infection and a preparation method thereof. Background technique [0002] Infectious rhinitis in rabbits is caused by the mixture of Pasteurella and Bordetella. It is easy to be mixed with coccidiosis in young rabbits, and it is easy to be mixed with Staphylococcus after adult rabbits. Rabbit infectious rhinitis is one of the diseases that often occur in rabbits, and the incidence rate can reach 20% to 70%. Factors that cause stress may include cold weather, pregnancy, complications, and experimental stress. The disease is common in large-scale farms, and it is a headache bacterial infectious disease; it is generally sporadic or endemic, and occurs all year round. The incubation period of the ...

AI Technical Summary

Problems solved by technology

For this reason, the present inventor adopts azithromycin at first with 40mg / kg body weight mixing material oral administration mode, feeds for 5 days, stops 10 days, test 2 months, observation has done preparatory control to rabbit Bordetella and Pasteurella The effect test shows that the drug has a good therapeutic effect on Bordetella rabbits and Pasteurella; however, it is also found that there are the following problems: First, although the oral administration of drug mixture is convenient for large-scale breeding farms, it cannot Due to the reduction of feed intake due to the illness of the rabbits, especially the severe disease rabbits even stop eating the feed, this just does not reach the requirement of taking an effective dose of medicine, and it is difficult to achieve the therapeutic effect; However, its toxicity is also relatively high. Therefore, it often occurs in the same breeding group. Healthy rabbits are poisoned or even dead due to excessive feed intake, while diseased rabbits are poor or even ineffective because of too small feed intake. Although the conventional dosage form of azithromycin has a good short-term therapeutic effect, it has no long-term sustained bactericidal effect. Once the drug is stopped, it is easy to re-infect Bordetella and Pasteurella. If the drug is taken continuously for a long time, drug resistance will inevitably occur. Simultaneously, in the process of developing the sustained-release agent of the drug, the inventor encountered a problem that the inclusion rate of the drug was low, only about 71%, and the effect was unstable in the application test.