Gingseng and aconite composition, its preparation, preparation process and usage

A technology of composition and aconite, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of difficult quality assurance, unclear material basis of preparations, and non-concentration of active substances, and achieve the effect of ensuring safety

Inactive Publication Date: 2007-04-25
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process adopts the commonly used extraction method of traditional Chinese medicine components. The active ingredients and parts of ginseng and aconite are not clearly defined, and the active substances are not concentrated, which makes the quality of the preparation uncontrollable, thus affecting the safety and effectiveness of clinical use.
Chinese patent applications CN 1557361, CN1488338, CN1488334, CN1488335, CN1488341, CN1488336, CN1488339, CN1488333, CN1493338, CN1493337, CN1500518, etc. disclose the prep

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0016] Preparation Example 1: Preparation of Ginseng Extract

[0017] Take 5 kg of ginseng, crush it, add 5 times the amount of water to soak, ultrasonically extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.1, add ethanol solution to make the alcohol concentration reach 70%, stir well, and precipitate overnight; filter, filtrate Concentrate under reduced pressure to remove alcohol; the concentrated solution is loaded on the treated macroporous adsorption resin column, the ratio of sample volume to resin volume is 5:1, first eluted with 30% ethanol to remove impurities, and then eluted with 60% ethanol Until the concentration of saponins was significantly reduced, the 60% ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain 320 g of ginseng extract with a yield of about 7%. The total saponin content of ginseng was 62%.

preparation example 2

[0018] Preparation Example 2: Preparation of Ginseng Extract

[0019] Take 3 kg of ginseng, crush it, add 10 times the amount of water to soak, ultrasonically extract twice, combine the extracts, concentrate under reduced pressure to a relative density of 1.05, add ethanol solution to make the alcohol concentration reach 70%, stir well, and precipitate overnight; filter, filtrate Concentrate under reduced pressure to remove alcohol; the concentrated solution is loaded on the treated macroporous adsorption resin column, the ratio of sample volume to resin volume is 5:1, first eluted with 30% ethanol to remove impurities, and then eluted with 60% ethanol Until the concentration of saponin is significantly reduced, collect the 60% ethanol eluate, concentrate under reduced pressure until it has no alcohol smell, put the sample on the treated polyamide chromatography column, wash with water to remove non-absorbed impurities, and elute with 10% ethanol for 2 discarded, and then elut...

preparation example 3

[0020] Preparation Example 3: Preparation of Aconite Extract

[0021] Take 1000g of aconite medicinal material, add 8000ml of water, adjust the pH value to 12 with 1N sodium hydroxide solution, soak at room temperature for 24 hours, until there is no aconitine and hypoaconitine identified by TLC. The residue is percolated with dilute hydrochloric acid solution to extract alkaloids, and the alkaloid precipitation reaction is detected until the extraction is complete; the filtrate and percolation liquid are combined, and the pH value of the solution is adjusted to 2 with dilute hydrochloric acid; the sample is applied to the treated 732 strongly acidic cation exchange The resin was replaced with ammonia solution, and the organic solvent was eluted. The eluate was collected and concentrated under reduced pressure to obtain 3.1 g of total alkaloids of aconite, with a yield of about 0.3%. The content of total alkaloids determined by acid dye colorimetry was 58%.

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Abstract

The invention discloses a pharmaceutical composition of ginseng and monkshood, wherein the content of monkshood alkaloid is not lower than 50%. The pharmaceutical composition provided by the invention has the advantages of controllable quality, better stability, and improved pharmacological actions. The monkshood alkaloid extract is prepared through specially treating monkshood, hydrolyzing di-ester aconitine in monkshood so as to convert it into low-toxicity alkaloid. The obtained composition can be used for treating infectious shock, bleeding shock and cardiogenic shock.

Description

technical field [0001] The invention relates to a ginseng composition, a preparation containing the composition, a preparation method and an application thereof. Background technique [0002] Ginseng is the dried root and rhizome of Panax ginseng C.A.Meyer, which has the functions of invigorating vitality, recovering pulses and solidifying, nourishing qi and absorbing blood. Taking blood, uterine bleeding, heart failure, cardiogenic shock. Aconitum is a processed product of the root of Aconitum carmichaeli Debx., a plant of Ranunculaceae. Cold in the uterus, cold pain in trusted subordinates, vomiting and diarrhea due to deficiency-cold, edema due to yin-cold, exogenous pathogenic factors caused by yang-deficiency, arthralgia due to cold-dampness. Modern pharmaceutical and pharmacological studies have shown that total ginseng saponins are the active parts of ginseng, which can excite the myocardium and increase myocardial contractility. Reduce myocardial oxygen consumptio...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P9/02A61P43/00
Inventor 马成俊蒋王林刘广
Owner SHANDONG LUYE PHARMA CO LTD
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