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Preparation method for trichlorsucrose

A technology for sucralose and sucrose, applied in 4 fields, can solve the problems of difficult preparation, harsh conditions, long time, etc., and achieve the effects of simple refining steps, less by-products, and improved utilization rate

Inactive Publication Date: 2007-05-16
清远天基谷醣实业有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to address the deficiencies in the existing sucralose single protection route production process, such as the difficulty in preparing the intermediate sucrose-6-carboxylate in the esterification protection step; and in the chlorination step, use Vismeier The conditions for the chlorination reaction of reagents are harsh and the time is long, etc.

Method used

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Examples

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Embodiment Construction

[0017] The first specific embodiment of the present invention, at first prepare, get a certain amount of ferric nitrate and hydrolyze with concentrated ammonia water, after hydrolysis is finished, the solid is washed with distilled water until no ammonium ion is detected (indicated by Nessler's reagent), through suction filtration , dried and weighed. Then soak the solid with 0.5mol / L sulfuric acid at a ratio of 15ml / g for 12 hours, filter it with suction, dry it at 110°C, burn it in a muffle furnace at 500°C for 3 hours, place it in a desiccator and seal it for later use.

[0018] Prepare intermediate product sucrose-6-acetate (S-6-A) subsequently, in 1000 milliliters of there-necked flasks that have water trap and good stirring, add successively 68.5 grams of sucrose (0.2mol), 12 grams of glacial acetic acid ( 0.22mol), 5 grams of solid superacid Fe 2 o 3 / SO 4 2- Catalyst (7.3% relative to the amount of sucrose) and 400 ml dimethylformamide, 200 ml cyclohexane. Turn on...

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PUM

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Abstract

The invention discloses a preparing method of trichloride saccharide, which comprises the following steps: esterifying 6-position in the sucrose to obtain intermediate; replacing through halogen selectively; alcoholyzing; selecting Vismeier agent (DMF / SOCl2) in the halogen replacing course irradiated through microwave; adopting carboxyl acid as esterifying agent and 1-11% or 10-14% solid hypercorrosive acid Fe2O3 / SO42- as catalyst.

Description

technical field [0001] The present invention relates to a preparation method of 4,1',6'-trichloro-4,1',6'-trideoxygalactose, commonly known as sucralose, English abbreviation TGS, trade name Sucralose. Background technique [0002] Sucralose is a new type of strong sweetener, which is characterized by high sweetness, which is 600 times that of sucrose; pure sweetness, the taste is basically the same as sucrose; stable performance, not easily damaged by harsh environments such as acid, alkali, and high temperature; It has a wide range of applications, can be used in almost all foods, and has high safety in food use; low in calories, non-rodent, suitable for diabetics and dental patients. [0003] The preparation technology of existing sucralose is basically carried out according to the following steps: [0004] Sucrose → esterification protection → selective chlorination → deprotection group → sucralose, in which esterification protection and chlorination are the key steps. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/02C07H1/00
Inventor 周若愚杨顺
Owner 清远天基谷醣实业有限公司
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