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Liquid formulation for treating allergic rhinitis

A technology for allergic rhinitis and liquid preparations, which is applied in the field of liquid preparations for the treatment of allergic rhinitis, can solve the problems of inability to generate local immune responses, immune memory, etc., and achieve the effects of fast onset, good stability and high patient compliance.

Inactive Publication Date: 2007-05-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional injection vaccines can only produce a systemic humoral immune response, but cannot produce a corresponding local immune response and long-term immune memory to the pathogen invasion site.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A liquid preparation for treating allergic rhinitis. When preparing 100 g of the liquid preparation: take 2 g of Tween 80, 5 g of Cremophor RH40, and 0.2 g of ethylparaben, put them into 60 g of distilled water, and heat them to 60° C. Cool into an aqueous solution; dissolve 1.5g of perilla seed oil, 1g of borneol, and 3g of lauryl alcohol in 20g of propylene glycol, then slowly add to the above aqueous solution, and stir while adding to obtain a clear and transparent liquid, add 0.1g of sodium metabisulfite, Add distilled water to a sufficient amount, mix evenly, subpackage, and sterilize to obtain 100 g of a liquid preparation for treating allergic rhinitis.

Embodiment 2

[0035] A liquid preparation for treating allergic rhinitis. When preparing 100 g of the liquid preparation: take 800.25 g of Tween, 25 g of Cremophor RH40, and 0.2 g of ethylparaben, put them into 60 g of distilled water, and heat them to 60° C. Cool into an aqueous solution; dissolve 6.8g of perilla seed oil, 2g of borneol, and 0.5g of lauryl alcohol in 5g of propylene glycol, and slowly add to the above aqueous solution, stirring while adding, to obtain a clear and transparent liquid, and add 0.1g of sodium metabisulfite , add distilled water to a sufficient amount, mix, subpackage, and sterilize to obtain 100 g of a liquid preparation for treating allergic rhinitis.

Embodiment 3

[0037] A liquid preparation for treating allergic rhinitis. When preparing 100 g of the liquid preparation: take 1 g of Tween 80, 15 g of Cremophor RH40, and 0.2 g of ethylparaben, and put them into 60 g of distilled water.

[0038] After heating to 60°C, cool naturally into an aqueous solution; dissolve 4g of perilla seed oil, 1.5g of borneol, and 1.5g of lauryl alcohol in 12.5g of propylene glycol, slowly add to the above aqueous solution, and stir while adding, to obtain a clear and transparent To the liquid, add 0.1 g of sodium metabisulfite, add distilled water to a sufficient amount, mix evenly, sub-package, and sterilize to obtain 100 g of a liquid preparation for treating allergic rhinitis.

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PUM

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Abstract

Disclosed is a liquid preparation for treating anaphylactic rhinitis, wherein the constituents include (by weight percent) purple perilla oil 1.5-6.8%, methyl glycol 5-2%, Tween80 0.25-2%, Cremophor RH 40 5-25%, borneol 1-2%, lauryl alcohol 0.5-3%, sodium metabisulfite 0.1%, Ethylparabenum 0.2%, and balancing distilled water to 100%.

Description

technical field [0001] The invention relates to a medical preparation containing plant material, in particular to a liquid preparation for treating allergic rhinitis. Background technique [0002] Allergic rhinitis is a chronic inflammatory disease of nasal mucosal tissue mediated by IgE. During the pathological process, the participation of various inflammatory cells and the release of various mediators, cytokines and some inflammatory active substances in the nasal mucosa tissue play an important role in the occurrence and development of inflammation and the appearance of nasal symptoms. effect. Currently, commonly used drugs for the treatment of allergic rhinitis include antihistamines, corticosteroids, chromones, decongestants, and antileukotrienes. Among them, antihistamines act quickly, but have poor effect on nasal congestion; corticosteroids can inhibit the inflammatory response of nasal mucosa, but have slow onset and are not suitable for some people; chromones ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61K47/34A61K9/08A61K9/10A61P11/02A61P37/08A61K31/045A61K47/26A61K47/44
Inventor 谢先吉饶跃峰谢方舟
Owner ZHEJIANG UNIV