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Preparation and use of immune formulation

A technology for deposits and tumor cells, applied to medical preparations containing active ingredients, peptide/protein components, powder delivery, etc., to achieve the effects of protecting and stabilizing protein structures, easy storage, and simple and easy operation methods

Inactive Publication Date: 2007-07-11
韩苏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although tumor cells can stimulate the body to produce antibody responses, it is difficult to stimulate CTLs to activate and initiate cellular immunity, which is one of the reasons why tumor cells can escape the body's immune surveillance

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0017] The precipitated product was extracted from the tumor tissue of the patient with renal cancer according to the above method, and more than 3 mg of the precipitated product could be obtained from 1 gram of tumor tissue. After desalination, concentration, and determination of protein content, the precipitated product is sterile filtered and subpackaged into 100ug / bottles and stored at -20°C, with a validity period of up to 1 year.

[0018] Immunotherapy can be started during the postoperative recovery period of the tumor resected patient, or during the recovery period after radiotherapy and chemotherapy. Use 300ul of water for injection to dissolve the content in the bottle, and do 2-3 points of intradermal injection near the patient's lymph nodes, giving an injection dose of about 100ul per point. Give the second immunization 2 weeks later, the method is the same as above. After 3 times of immunization, immunize once every month, and then immunize once every six months ...

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PUM

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Abstract

The invention relates to an immunity biological treatment that extractive protein from cancer organism or cancer cell, wherein it uses ammonia sulfate to deposit the protein component from cancer organism slurry or cancer cell crack liquid; the deposit contains requco protein group and relative cancer antigens; removes salt, concentrates, freezes and dries, the extractive can be directly prepared into injection of external agent to excite the immunity cell to the cancer patient, and the immunity system will recognize and kill cancer cell.

Description

technical field [0001] The invention belongs to the fields of biomedicine and biotechnology. technical background [0002] The reason why the human body can survive in a complex environment is because the body has the ability to resist pathogens invaded by foreign sources and eliminate mutated cells in the body. The human immune system has two mechanisms of humoral immunity and cellular immunity. Humoral immunity is an immune response mediated by B lymphocytes. B lymphocytes develop and mature in the spleen and bone marrow. Antibodies produced by B lymphocytes can specifically recognize and bind exogenous biomacromolecules to block exogenous Injury to the body. The complex formed by the antigen-antibody can stimulate the body's complement response and cellular response, and phagocytize and degrade the pathogen carrying the foreign biological macromolecule to eliminate the invading pathogen. Cellular immunity is based on the immune response mediated by T lymphocytes. Anti...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/19A61P35/00
Inventor 韩苏
Owner 韩苏
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