Method for preparing aqueous nontoxic degradable polyurethane elastomer

A polyurethane elastomer, water-based technology, applied in the field of preparation of water-based non-toxic and degradable polyurethane elastomer, can solve the problems of restricting the normal use of medical devices, increasing the production cost of products, yellowing of emulsions and products, and achieving good strength and saving. Energy, the effect of increasing stability

Active Publication Date: 2007-07-11
SICHUAN UNIV
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  • Application Information

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Problems solved by technology

However, these methods have a common disadvantage: the synthesis of polyurethane is carried out in organic solvents, which will not only pollute the environment, but also increase the production cost of the product.
The water-based polyurethane emulsion obtained by the above two methods uses aromatic diisocyanate TDI and MDI in the preparation process, which will not only cause the emulsion and the product to turn yellow during storage, but the product will also produce carcinogenic anilines during use. Substances, which limit its normal use as a medical device, this may be the main reason why their finished products have not really been marketed until now
At the same time, in the polyurethanes introduced in these patents, when the soft segments are all stable monomers, such as polyethylene glycol, polypropylene glycol, etc., non-degradable polyurethanes are obtained, which also limits their application in tissue engineering

Method used

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  • Method for preparing aqueous nontoxic degradable polyurethane elastomer

Examples

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Embodiment 1、2

[0047] These two are examples in which no chain extension reaction is performed.

[0048] Firstly, polyester polyol and polyether polyol are added to a reaction kettle equipped with a stirrer, a thermometer and nitrogen protection, heated to raise the temperature, and vacuum dehydrated, then lowered the temperature, and then added diisocyanate and catalyst for prepolymerization reaction; after the reaction , under strong stirring, add water to emulsify, and the emulsification ends to obtain a light blue transparent polyurethane aqueous emulsion. The emulsion can be used to prepare products with lower strength requirements, such as drug carriers and the like. The raw material formula of each embodiment is shown in Table 1, and the process control conditions are shown in Table 2.

Embodiment 3～7

[0050] Firstly, polyester polyol and polyether polyol are added to a reaction kettle equipped with a stirrer, a thermometer and nitrogen protection, heated to raise the temperature, and vacuum dehydrated, then lowered, and then added diisocyanate and catalyst for prepolymerization reaction; lowered the temperature again, And add low-molecular-weight chain extender I to carry out chain extension reaction; under strong stirring, add water to emulsify, add low-molecular-weight chain extender II at the same time to extend the chain again, and dropwise add neutralizer to neutralize the carboxyl groups generated, and the emulsification is completed to obtain Slight blue transparent polyurethane aqueous emulsion. The emulsion can be used to prepare products with high mechanical performance requirements, such as artificial heart valves, artificial cardiac pacemaker insulated wires, artificial blood vessels, artificial blood vessel stents and the like. The raw material formula of each ...

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Abstract

The invention discloses a making method of aqueous intoxic degraded polyurethane elastomer, which comprises the following steps: heating the polymer diatomic alcohol; dehydrating in the vacuum; cooling; adding diisocyanate and catalyst to prepolymerize; stirring through strong force; adding water to emulsify; cooling after prepolymerizing; adding low-molecular chain-extending agent I to lengthen chain; stirring through strong force; adding water to emulsify; cooling after prepolymerizing; adding low-molecular chain-extending agent II to lengthen chain again; dripping neutral agent to manufacture carboxyl; moulding the emulsion to obtain the product.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of polyurethane elastomers, and in particular relates to a preparation method of water-based non-toxic and degradable polyurethane elastomers. technical background [0002] Although polyurethane materials are widely used in the manufacture of long-term implanted medical devices and artificial organs, such as artificial heart valves, due to their excellent mechanical properties, wear resistance, lubricity, fatigue resistance, biocompatibility, and processability, etc. , artificial cardiac pacemaker insulated wire, artificial blood vessels, artificial vascular stents, artificial joints, artificial skin, artificial cartilage, etc. However, these non-degradable materials need a second surgery to remove them after performing their mission, which will undoubtedly Cause secondary trauma and pain to the patient. [0003] With the development of biomaterials, people increasingly hope that the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/08C08G18/42C08G18/48C08G18/76C08G18/24C08G101/00
Inventor 钟银屏谭鸿蒋霞李洁华谢兴益何成生樊翠蓉
Owner SICHUAN UNIV
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