Beta-lactam antibiotic-containing tablet and production thereof
a technology of betalactam and antibiotics, applied in the direction of antibacterial agents, drug compositions, dispersed delivery, etc., can solve the problems of patients feeling discomfort or anxiety, patients suffering unnecessary pain, and capsules are indeed difficult to tak
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
example
Example 1
[0060] Water was added to saccharin calcium and the mixture was granulated by a conventional method, followed by drying, sieving and sizing to give saccharin calcium granules not less than 150 .mu.m in particle size.
[0061] According to the formulation shown below, micronized cefixime bulk substance, microcrystalline cellulose, low-substituted hydroxypropylcellulose (L-HPC) and polyvinylpyrrolidone were weighed and mixed together, water was then added, and the mixture was granulated. The granulation product was dried under flowing air at 40.degree. C. for 17 hours and then sized using a 500-.mu.m sieve. The granules sieved out were mixed with magnesium stearate, light anhydrous silicic acid, strawberry flavor and the above-mentioned granulated saccharin calcium according to the formulation shown below, followed by compressing on a single-punch tablet machine to give tablets each having the specified weight.
8TABLE 8 Micronized cefixime bulk 448.9 mg (400 mg potency) substance...
example 2
[0062] Saccharin calcium and light anhydrous silicic acid were mixed together in a ratio of 20:1 and then water was added. The resultant mixture was granulated by a conventional method, followed by drying and sizing to give a granulated mixture of saccharin calcium and light anhydrous silicic acid (75-500 .mu.m in particle size).
[0063] Then, tablets were produced following the procedure of Example 1 except that 21 mg of the above granulated mixture was used in lieu of 20 mg of saccharin calcium (Example 1, Table 8).
example 3
[0064] Saccharin calcium and hydrated silicon dioxide were mixed together in a ratio of 20:1 and then water was added. The resultant mixture was granulated by a conventional method, followed by drying and sizing to give a granulated mixture of saccharin calcium and hydrated silicon dioxide (75-500 .mu.m in particle size).
[0065] Then, tablets were produced following the procedure of Example 1 except that 21 mg of the above granulated mixture was used in lieu of 20 mg of saccharin calcium (Example 1, Table 8).
PUM
Property | Measurement | Unit |
---|---|---|
Weight | aaaaa | aaaaa |
Weight | aaaaa | aaaaa |
Weight | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com