Process for preparing dry extracts
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Example 1
[0052] 146.5 kg of St. John's wort (SJW) extract having a dry content of 47.8% was spray-dried together with 30.00 kg of silicified / silicated microcrystalline cellulose at an air entry temperature of 210.degree. C. and under a nozzle pressure of 40 bar to obtain 93.6 kg of dry product.
Example
Comparative Example 1a
[0053] 5.0 kgs of commonly produced St. John's wort dry extract comprising of 65% native extract and about 35% excipients like Maltodextrin (30%) and silicon dioxide (5%) was added to 2,5 kgs of silicified / silicated microcrystalline cellulose and mixed in a pilot plant blender. The moisture uptake, the powder flowability and the compactability was compared with product of Example 1 in Table 1:
1TABLE 1 Comparison of Properties of St. John's Wort Products Hardness of Hardness of Moisture Compact- the pressed the pressed Speed of Product Flowability Uptake ability tablets tablets Encapsulation St. John's Wort Very good Low Very good High High - No High - No of Example 1 stop stops necessary necessary St. John's Wort Good Fair Poor Fair Poor - Poor - Multiple of Comp. Multiple stop stops for Example 1 for cleaning cleaning
[0054] Speed of encapsulation: comparable trial was preformed at standard encapsulation machine (e.g., Bosch 330) to judge over the impact of flo...
Example
Example 2
[0055] 132.2 kgs of Panax ginseng (PG) extract having a dry content of 43.8% was spray-dried together with 25.0 kgs of silicified / silicated microcrystalline cellulose at an air entry temperature of 205.degree. C. and under a nozzle pressure of 40 bar to obtain 83.6 kg of dry product.
Comparative Example 2a
[0056] 235.0 kgs of Panax ginseng (PG) extract having a dry content of 39.7% was spray-dried together with 23.3 kgs of physical mixture of microcrystalline cellulose and colloidal silicon dioxide (96% MCC and 4% SiO2, e.g., Aerosil) at an air entry temperature of 215.degree. C. and under a nozzle pressure of 36 bar to obtain 83.6 kg of dry product. The moisture uptake, the powder flowability and the compactability was compared with product of Example 2.
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