Process for preparing dry extracts

Inactive Publication Date: 2003-06-05
J RETTENMAIER & SOEHNE GMBH CO KG ROSENBERG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0008] In view of the shortcomings of conventional extract spray drying processes, it is an object of the present invention to

Problems solved by technology

In practice, this form of common spray drying results in products having undesirable characteristics, tending to form hygroscopic (moisture retaining) and therefore "sticky" or "gummy" products.
Attempts to apply a common spray dry process therefore often fail.
This mixing of powders is also problem

Method used

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  • Process for preparing dry extracts
  • Process for preparing dry extracts
  • Process for preparing dry extracts

Examples

Experimental program
Comparison scheme
Effect test

Example

Example 1

[0052] 146.5 kg of St. John's wort (SJW) extract having a dry content of 47.8% was spray-dried together with 30.00 kg of silicified / silicated microcrystalline cellulose at an air entry temperature of 210.degree. C. and under a nozzle pressure of 40 bar to obtain 93.6 kg of dry product.

Example

Comparative Example 1a

[0053] 5.0 kgs of commonly produced St. John's wort dry extract comprising of 65% native extract and about 35% excipients like Maltodextrin (30%) and silicon dioxide (5%) was added to 2,5 kgs of silicified / silicated microcrystalline cellulose and mixed in a pilot plant blender. The moisture uptake, the powder flowability and the compactability was compared with product of Example 1 in Table 1:

1TABLE 1 Comparison of Properties of St. John's Wort Products Hardness of Hardness of Moisture Compact- the pressed the pressed Speed of Product Flowability Uptake ability tablets tablets Encapsulation St. John's Wort Very good Low Very good High High - No High - No of Example 1 stop stops necessary necessary St. John's Wort Good Fair Poor Fair Poor - Poor - Multiple of Comp. Multiple stop stops for Example 1 for cleaning cleaning

[0054] Speed of encapsulation: comparable trial was preformed at standard encapsulation machine (e.g., Bosch 330) to judge over the impact of flo...

Example

Example 2

[0055] 132.2 kgs of Panax ginseng (PG) extract having a dry content of 43.8% was spray-dried together with 25.0 kgs of silicified / silicated microcrystalline cellulose at an air entry temperature of 205.degree. C. and under a nozzle pressure of 40 bar to obtain 83.6 kg of dry product.

Comparative Example 2a

[0056] 235.0 kgs of Panax ginseng (PG) extract having a dry content of 39.7% was spray-dried together with 23.3 kgs of physical mixture of microcrystalline cellulose and colloidal silicon dioxide (96% MCC and 4% SiO2, e.g., Aerosil) at an air entry temperature of 215.degree. C. and under a nozzle pressure of 36 bar to obtain 83.6 kg of dry product. The moisture uptake, the powder flowability and the compactability was compared with product of Example 2.

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Abstract

Processes for preparing dry extracts from fluid extracts and at least one additional substance by a spray-drying process is effected by adding the additional substance to the spray-drying process in a dry form.

Description

[0001] This application is a continuation-in-part of U.S. application Ser. No. 09 / 986,116 filed Nov. 7, 2001, which is incorporated herein by reference in its entirety.[0002] The present invention relates to new processes for preparing dry extracts having superior flow characteristics, and extracts made by such processes.[0003] Biologically, chemically and / or pharmaceutically active agents are often derived from natural sources in liquid form (including solutions, suspensions, emulsions, slurrys, pastes or other mixtures, hereinafter, "fluid"). This is particularly the case with plant extracts. Extracts from plant parts and / or plant preparations are widely employed in many industries, including but not limited to the feed, food, functional food, nutraceutical, dietary supplement and pharmaceutical industries. It is often desirable to dry these extracts to reduce their volume and / or to improve their handling and processing characteristics.[0004] Spray drying is a known and very impor...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/16A61K36/00A61K47/04A61K47/12A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38
CPCA61K36/28A61K36/77B01J2/04A61K36/8962A61K2236/51A61K36/82
Inventor BERKULIN, WILHELMTHEISSING, KARL-HANS
Owner J RETTENMAIER & SOEHNE GMBH CO KG ROSENBERG
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