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Composite of support matrix and collagen, and process for producing support substrate and composite

Inactive Publication Date: 2006-09-28
TEIJIN LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015] It is an object of the present invention to provide a matrix having high stretchability and an adequate Young's modulus (elastic modulus), as a tube which can serve as the matrix for an artificial vessel or for neural regeneration.

Problems solved by technology

These publications describe tubes having synthetic resins woven into a plain weave or knit as the matrix for an artificial vessel, nonwoven fabric tubes formed from a synthetic resin shaped into a filament and roll laminated on a mandrel, or tubes obtained by extrusion molding of a mixture of a synthetic resin and a particulate aqueous solution of sodium chloride, but all of these methods yield artificial vessel matrix tubes which lack stretchability and have unsatisfactory Young's moduli.
Since the aforementioned silicon, polyurethane, polytetrafluoroethylene and polyester materials lack bioabsorption properties, they are associated with problems from the standpoint of long-term safety, while compression and damage to regenerated nerves and vessels is also a concern.
Also, polylactic acid, polyglycolic acid, polycaprolactone and their copolymers, while having bioabsorption properties, are problematic in terms of Young's modulus and stretchability, and can likewise lead to compression and damage to regenerated nerves and vessels.
These problems can potentially be overcome by using composites of elastic materials such as collagen with support matrices made of polylactic acid, polyglycolic acid, polycaprolactone and their copolymers, but since conventionally known support matrices made of polylactic acid, polyglycolic acid, polycaprolactone and their copolymers lack stretchability, they counter the elastic property of the collagen and thus limit the use of such materials in the body.
In other words, the currently known support matrices made of polylactic acid, polyglycolic acid, polycaprolactone and their copolymers, and composites of such support matrices with collagen, do not exhibit excellent stretchability.

Method used

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  • Composite of support matrix and collagen, and process for producing support substrate and composite

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0091] A dope was prepared by mixing 1 g of polylactic acid and 8 g of methylene chloride at room temperature (25° C.). An apparatus such as shown in FIG. 2 was used for 5 minutes of discharge of the solution to a fiber substance collecting electrode 5 (2 mm diameter, 200 mm length, 70-S surface roughness), causing rotation at 60 rpm. During this time, the collecting electrode 5 was rotated 150 rpm in the circumferential direction. The inner diameter of the ejection nozzle 1 was 0.8 mm, the voltage was 12 kV, and the distance from the ejection nozzle 1 to the fiber substance collecting electrode 5 was 10 cm. The end of the fiber structure collected at the fiber substance collecting electrode 5 was held fixed against a finger while the fiber substance collecting electrode 5 was pulled out toward the end fixed against the finger, to obtain a polylactic acid tube. The obtained polylactic acid tube had a diameter of 2 mm, a length of 20 mm, a basis weight of 20 g / m2, a bellows-shaped se...

example 2

[0092] The same treatment was carried out as in Example 1, except that the basis weight was 40 g / m2.

example 3

[0093] A 2 mm-diameter rod was reinserted into the polylactic acid tube obtained in Example 1, and this was fixed at the center of a 3 mm diameter tube. A 1.5 unit volume of a buffer solution containing 260 mM sodium bicarbonate, 200 mM HEPES and 50 mM sodium hydroxide was mixed with a 10 unit volume of 0.3% aqueous (type II) collagen solution by Koken Co., Ltd., while cooling on ice, and the mixture was placed in the holding tube in which the polylactic acid tube was fixed. A procedure in which the external atmosphere pressure was reduced and restored to ordinary pressure was repeated three times, and then the tube was kept at 37° C. for gelling. After gelling, the 2 mm diameter rod was pulled out and lyophilization was carried out to obtain a collagen cylindrical body.

[0094] The yield elongation of the obtained molded article was measured using a Tensilon device (INSTRON) with reference to DIN53507, 53504, giving a yield elongation value of 38%.

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Abstract

A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g / m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite comprising the cylindrical body and collagen.

Description

TECHNICAL FIELD [0001] The present invention relates to a composite composed of collagen and a support matrix made of a fiber structure composed of aliphatic polyester fibers with a mean fiber size of 0.05-50 μm, to a cylindrical support matrix having a bellows-shaped section, and to a method for production of the support matrix and a method for production of the composite. BACKGROUND ART [0002] Recent years have seen an increase in active research in regenerative medicine, a technical field which takes advantage of the ability of cells to differentiate and proliferate to achieve reconstruction of original biological tissues and organs, as a method for treating major injury to or loss of biological tissue and organs. Neural regeneration is a branch of this field, and research is underway toward using tubes composed of artificial materials for crosslinking between stumps in the neuron-deficient sites of patients with ablated neural tissue, to induce regeneration of the neural tissue....

Claims

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Application Information

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IPC IPC(8): A61F2/06A61F2/02A61F2/04A61F2/08A61L27/00A61L27/34
CPCA61F2/06A61F2210/0004A61L27/34C08L89/06
Inventor KITAZONO, EIICHIMIYOSHI, TAKANORIKANEKO, HIROAKISUMI, YOSHIHIKOFUKUHIRA, YUKAKO
Owner TEIJIN LTD
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