Modulation of cell fates and activities by phthalazinediones

a technology of phthalazinedione and cell fate, which is applied in the direction of drug compositions, immunological disorders, metabolism disorders, etc., can solve the problems of defective protein products that function abnormally or not at all, defective proteins that could disrupt certain cellular processes, and leave the cell's redox system depleted and unstabl
US20070142303A1Inactive Publication Date: 2007-06-21BACH PHARMA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BACH PHARMA
Publication Date
2007-06-21
Estimated Expiration
Not applicable · inactive patent
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Abstract

Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.
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Description

[0001] This application is a divisional of application Ser. No. 11 / 199,394 filed Aug. 8, 2005, which is a continuation-in-part of application Ser. No. 10 / 283,647 filed Oct. 30, 2002, now U.S. Pat. No. 6,953,799, which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] Current medical treatments generally focus on the disease and strive to eliminate the inciting agent or the symptoms, often injuring healthy tissue in the process. The present invention focuses instead on the patient, to enable self-repair mechanisms by supporting the patient's body in controlling or stabilizing its cellular functions without toxic side effects. The methods and compositions of the invention comprise phthalazinedione compounds that buffer intracellular reduction and oxidation (redox) reactions and thereby modulate cellular functions of growth, differentiation, activity, and death in various disease states.

[0003] In healthy cells, a balance of redox reactions maint...

Claims

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