Combination therapy for treating protein deficiency disorders

a protein deficiency and therapy technology, applied in the field of protein deficiency disorders, can solve the problems of inability of proteins vectors infecting or transducing dividing cells, and inability to cross the blood-brain barrier, etc., to achieve the effect of enhancing the stability of purified proteins
US20070178081A1Inactive Publication Date: 2007-08-02FAN JIAN QIANG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
FAN JIAN QIANG
Publication Date
2007-08-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.
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Description

[0001] This application is a divisional of U.S. application Ser. No. 11 / 317,404, filed on Dec. 23, 2005 (pending), which is a continuation of U.S. application Ser. No. 10 / 771,236, filed on Feb. 2, 2004 (abandoned), which claims priority benefit from U.S. Provisional Application Ser. No. 60 / 444,136, filed Jan. 31, 2003 (abandoned), each of which is incorporated by reference herein in its entirety.FIELD OF THE INVENTION

[0002] This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides compositions comprising the purified protein and an ASSC. BACKGROUND Protein Deficiency

[0003] Proteins are synthesized intracellularly according to the genomic nucleotide sequence of a particular gene through transcription, translation, and other processes. Protein deficiency can be caused by a m...

Claims

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