Method of bowel cleansing

a bowel cleansing and bowel technology, applied in the digestive system, medical preparations, drug compositions, etc., can solve the problems of reducing affecting the effect of bowel cleansing, and generally uncomfortable for patients to complete, so as to reduce the volume of liquid input and ensure the effect of effective colon cleansing

a bowel cleansing and bowel technology, applied in the digestive system, medical preparations, drug compositions, etc., can solve the problems of reducing affecting the effect of bowel cleansing, and generally uncomfortable for patients to complete, so as to reduce the volume of liquid input and ensure the effect of effective colon cleansing

US20070298008A1Inactive Publication Date: 2007-12-27BRAINTREE LAB
10 Cites 17 Cited by

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] It has been determined, surprisingly, that a specific regimen of a stimulant laxative, such as bisacodyl, which precedes by a biologically-defined interval the consumption of a reduced volume of an orthograde lavage solution, produces a superior combination of bowel cleanliness (as judged by the physician), a reduced regimen preparation time and an improved patient acceptance of the procedure. This regimen of laxative and lavage produces results that are superior and different from either laxative or reduced volume lavage alone, or what might be expected from their combination in a purely additive manner, or that would be expected if the specific regimen is not followed. Furthermore, this method permits the use of a lower volume of the lavage solution than if it were to be used alone. Additionally, this regimen results in reduced occurrence of most common symptoms complained of by patients. Finally, it has been discovered that this dual modality treatment is most advantageous...

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Abstract

Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic lavages, or smaller volume hypertonic lavages.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This application is a continuation of U.S. application Ser. No. 10 / 277,620 entitled “Method of Bowel Cleansing,” filed Oct. 22, 2002, the contents of which is herein incorporated by reference.FIELD OF THE INVENTION [0002] We have now discovered a new method that can be used to safely and effectively cleanse a patient's bowels, especially the colon prior to diagnostic or surgical procedures. BACKGROUND INFORMATION [0003] Although years of clinical research have been expended to make early detection of colorectal cancer (CRC) a high clinical priority, the disease remains the second leading cause of cancer-related death in the United States. In 1999, an estimated 60,000 deaths were attributed to CRC which accounted for the third highest number of new cancer cases that year, only lagging prostate and respiratory cancers for men and breast and respiratory cancers in women. Investigators estimate there were 129,000 new cases in 1999 alone. Lif...

Claims

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Application Information

Patent Timeline
27 Dec 2007
Publication
US20070298008A1
IPC
A61K31/765; A61P1/10
CPC
Y10S514/892; A61K31/765; A61P1/10
Inventors
DENNETT, EDMUND V.; RALEIGH, ROBERT M. JR.