35 results about "Colonic contents" patented technology

The field of colonic diagnostic and surgical procedures is hampered by the lack of optimal means available to cleanse the colon. A compromise between convenient, distasteful, solid or low volume, hyperosmotic solutions which cause considerable fluid and electrolyte imbalances in patients and large volume, difficult to consume, iso-osmotic solutions has had to be made heretofore. This invention describes a low volume, hyper-osmotic solution consisting of sulfate salts with and with out polyethylene glycol. Unlike prior art, this composition is useful for the cleansing of the bowel and, in lower volumes, as a laxative, without producing clinically significant changes in bodily function.

The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.

A system for performing a virtual colonoscopy includes a system for generating digital images, a storage device for storing the digital images, a digital bowel subtraction processor coupled to receive images of a colon from the storage device and for removing the contents of the colon from the image and an automated polyp detection processor coupled to receive images of a colon from the storage device and for detecting polyps in the colon image.

Apparatus for effecting colonic transit having a pad, defining a guide groove to overly the abdomen of a person, a roller, movable along the guide groove to apply pressure progressively along the groove to effect movement of colonic contents along the colon. The guide groove may be defined in a pad or may be defined by ridges extending outwardly of a member such as a pad. The roller may comprise a handle and a roller wheel, with the wheel preferably swivelly mounted relative to the handle.

Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic ravages, or smaller volume hypertonic lavages.

The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.

A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and / or (b) simethicone and / or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and / or (b) and / or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention.

A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and / or a phosphorus containing composition administered in sequential doses for preparing a colon prior to colonoscopy.

A method of colon cleansing that provides superior cleansing. In an embodiment, superior cleansing of the right colon is provided. In an embodiment, a stimulant laxative is consumed at least two days prior to the day for which maximum cleansing is desired, and an osmotic purgative is consumed one day prior to the day for which maximum cleansing is desired. A regimen that administered PICO-SALAX® plus BISACODYL™ was superior in cleansing the right colon compared to PICO-SALAX® alone, and when compared to Oral Sodium Phosphate. Patient tolerability and safety were excellent.

The invention relates to sea buckthorn calcium and a preparation method thereof, wherein, the sea buckthorn calcium comprises the following ingredients by weight percentage: calcium fruit powders accounting for 40 to 60 percent, sea buckthorn powders accounting for 10 to 30 percent, asparagus powders accounting for 10 to 25 percent and collagen protein powders accounting for 5 to 20 percent. The sea buckthorn calcium and the preparation method thereof can achieve better calcium absorption efficiency, can also achieve the efficacies of cancer prevention and treatment as well as beauty, and canachieve the auxiliary efficacies lowering cholesterol and blood fat, enhancing blood vessel elasticity, lowering blood pressure, reducing platelet aggregation and reducing heart attack. The sea buckthorn calcium and the preparation method thereof can regulate hyperglycemia, can reduce diabetic shock, and can reduce the attack probability of rectal cancer and gastric cancer. Sea buckthorn calcium can be combined with fat, so that the effects of colon cleansing, detoxication and blood cleaning can be achieved, and impurities in human bodies can be eliminated. The sea buckthorn calcium is particularly suitable for being taken by middleaged and elderly people, patients suffered from high blood pressure, hyperlipidemia, diabetes and hyperglycemia and the people easy to catch a cold.

This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and / or (b) simethicone and / or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and / or (b) and / or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention.

The invention provides a colon cleansing solution comprising:a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of:(i) ascorbic acid and(ii) one or more salts of ascorbic acidthe components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; andb) 10 to 200 g per litre polyethylene glycol.The invention also provides methods an kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.

A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and / or a phosphorus containing composition administered in sequential doses for preparing a colon prior to colonoscopy.

The invention provides an automatic medical temperature control colon cleansing device which comprises a power circuit, a power drive circuit, a heater and a thermistor which are all electrically connected. A test probe of the thermistor stretches into the heater. The automatic medical temperature control colon cleansing device further comprises a single chip microcomputer connected with the power drive circuit in a control mode. The two ends of the thermistor are connected to a same-direction input end and a reverse-direction input end of an operational amplifier respectively. An output end of the operational amplifier is connected to a voltage signal acquisition pin of the single chip microcomputer. An output duty ration pin of the single chip microcomputer is connected to the power drive circuit. The heater is powered to heat liquid and raises the temperature of the liquid. The resistance value of the thermistor changes along with changes of the temperature of the heater. The resistance value changing along with changes of the temperature is converted into a voltage value and the voltage value is then amplified and converted. The power loaded on the heater is controlled and adjusted according to the processing result so as to adjust the temperature of the liquid, and the purposes of automatic detection and temperature control are achieved; meanwhile, the acquired voltage signals are more accurate through introduction of the digital acquisition technology, and temperature control accuracy is improved.

A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

The present invention provides peptides and compositions useful in the treatment of gastrointestinal disorders or for colon cleansing. The invention also provides compositions and methods for treating gastrointestinal disorders and pharmaceutical compositions for implementing the same. In some embodiments, the pharmaceutical compositions include oral dosage forms.

The present invention provides an oligonucleotide comprising the sequence 5 '-GGAACAGTTCGTCCATGGC-3' (SEQ ID NO: 2) for use in the treatment of inflammatory bowel disease in a human subject by topical administration to the colon wherein the subject has not been subjected to colon cleansing prior to said administration.

A method for electronically cleansing a virtual object formed from acquired image data converted to a plurality of volume elements is provided. The present method allows individual volume elements, or voxels, to represent more than one material type. The method includes defining a partial volume image model for volume elements representing a plurality of material types based, at least in part, on the measured intensity value of the volume element. The material mixture for each of the volume elements representing a plurality of material types can be estimated using the observed intensity values and the defined partial volume image model. The volume elements representing a plurality of material types can then be classified in accordance with the estimated material mixture. For electronic colon cleansing, the method includes removing at least one classification of volume elements when displaying the virtual object.

The invention discloses a method for preparing colon-cleansing particles used before gynecological surgery and aims to solve the treatment problem before gynecological surgery. The method is characterized in that the colon-cleansing particles are prepared by the following active pharmaceutical ingredients: by weight proportion, horseweed herb, fructus cinnamomi, radix ranunculi ternati, Chinese starjasmine stem, herbof denseflower bulbophyllum, rhizoma polygonati, dipsacus roots, tangerine peel, sunflower flowers, turbo cornutus solander, amblystegium serpens and magnesium sulfate. The method includes the following steps: (1), extracting volatile oil from dipsacus roots, fructus cinnamomi and herbof denseflower bulbophyllum coarse powder for standby use; (2), smashing turbo cornutus solander and amblystegium serpens into fine powder for standby use; (3), adding water in horseweed herb, radix ranunculi ternati, Chinese starjasmine stem, rhizoma polygonati, sunflower flowers and tangerine peel for decoction twice, filtering, combining filtrate, concentrating the filtrate, adding ethanol for deposition, taking supernate, recycling ethanol and concentrating to obtain thick paste; (4), adding the volatile oil obtained in step 1 and the fine powder and magnesium sulfate obtained in step 2 in the thick paste obtained in step 3, uniformly stirring, forming particles, drying and obtaining the colon-cleansing particles. Clinical experiments show that the colon-cleansing particles have good colon-cleansing effect when used before gynecological surgery, and the colon-cleansing particles are worthy of clinical popularization and application.

The invention discloses a method for detecting short-chain fatty acids in mouse gut-brain axis related tissues, involving brain tissue, colon tissue, colon contents and feces, and comprising the following steps: detecting brain tissue, colon tissue, colon contents and feces. Pretreatment of feces to obtain brain tissue, colon tissue, colon contents and fecal extract; adding internal standard to brain tissue, colon tissue, colon contents and fecal extract, and adding pentafluorobromine for derivatization reaction ; After the derivatized solution is extracted, the acetic acid, propionic acid and butyric acid in the extract are detected by GC-MS. The invention establishes a gas chromatography-mass spectrometry rapid determination method for detecting three kinds of short-chain fatty acids in brain tissue, colon tissue, colon content and feces through a derivatization method. Pre-process and derivatize different biological samples, and add internal standard for correction to achieve accurate quantification.

The invention discloses an endoscopic-operation preoperative oral colon cleansing decoction preparation method in order to solve the problem about endoscopic-operation preoperative oral colon cleansing decoction of urinary surgical department. The endoscopic-operation preoperative oral colon cleansing decoction preparation method is characterized by including: mixing components comprising, by weight, 10-30 parts of horseweed herbs, 6-12 parts of fructus cinnamomi, 3-10 parts of ternate buttercup roots, 6-12 parts of Chinese starjasmine stems, 3-10 parts of herba alyxiae sinensis, 6-12 parts of mulberries, 6-12 parts of dipsacus roots, 6-12 parts of tangerine peels, 6-12 parts of sunflowers, 1-5 parts of turbo cornutus solander, 3-10 parts of amblystegium serpens and 10-25 parts of magnesium sulfate with water for decoction; obtaining filter liquor after 30 minutes; adding water to herb residues for continuous decocting for 20 minutes prior to obtaining the filter liquor; combining the primary and secondary filter liquor into the decoction. Clinic trials prove that good preoperative colon cleansing effect of endoscopic operation of the urinary surgical department is achieved, and the method is worthy of application and promotion.

The invention discloses a colon-cleansing drug used before urinary endoscopic surgery and aims to solve the problem of treatment before urinary endoscopic surgery. The colon-cleansing drug is characterized by being prepared by the following active pharmaceutical ingredients, by weight proportion, horseweed herb, fructus cinnamomi, radix ranunculi ternati, Chinese starjasmine stem, clausena excavata burm, mulberry, dipsacus roots, tangerine peel, sunflower flowers, turbo cornutus solander, amblystegium serpens and magnesium sulfate. Clinical experiments show that the colon-cleansing drug has good colon-cleansing effect when used before urinary endoscopic surgery, and is worthy of clinical application and popularization.

The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.

The present invention relates to a solid colonic purgative for oral administration, containing anhydrous magnesium sulfate, potassium sulfate and anhydrous sodium sulfate and additionally containing simethicone. The present invention exhibits, even when dosage is reduced by up to approximately 20%, a colon cleansing effect that is more satisfactory than that of a conventional colonic purgative consisting of anhydrous magnesium sulfate, potassium sulfate and anhydrous sodium sulfate. In addition, since the dosage of the present invention is decreased to be less than that of a conventional product, a foul taste or odor caused by a main ingredient is reduced and ingestion amount of the preparation and water is small such that the drug compliance is significantly improved. Furthermore, unlikea conventional solid colonic purgative, the present invention can be prepared as a tablet even without containing a water-soluble lubricant. In other words, the present invention can be prepared as asolid preparation for oral administration by containing a water-soluble lubricant, but can be prepared as a solid preparation for oral administration even when a water-soluble lubricant is excluded.