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Pack

a technology of medicinal tablets and packaging, applied in the field of packaging, can solve the problem that the storage of medicinal tablets may be affected by moistur

Inactive Publication Date: 2008-01-31
ALLIANCE PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a pack of medicinal tablets containing a phenothiazine derivative that are protected from water damage. The tablets can be in the form of a blister pack or a flexible flat pack. The pack is made of a water-occlusive material, such as a metallic foil or a water-occlusive wall material. The pack can also contain other components such as monosaccharides or disaccharides, as well as xanthan gum and locust bean gum. The pack can have a use-by date at least six months after its packing. The technical effect of the invention is to provide a convenient and reliable way to protect and administer tablets of a phenothiazine derivative."

Problems solved by technology

We have discovered unexpectedly that in a traditional PVC / PVdC blister pack having tablets containing prochlorperazine maleate as the active ingredient, the stored tablets may be affected by moisture.

Method used

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Examples

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Effect test

Embodiment Construction

[0029] The invention will now be further described, by way of example, with reference to the following illustrative examples.

[0030] Medicament tablets were made, containing the following ingredients.

ComponentQuantity / tablet (mg)FunctionProchlorperazine6.00Active ingredientmaleateCompressible sugar46.32Filler / bulking agentPovidone K303.00BinderLocust bean gum1.50Gelling agentXanthan gum1.50Gelling agentTalc, sterilized1.00Glidant (compression aid)Magnesium stearate0.50Lubricant (compression aid)B-carotene 1% CWS0.18Coloring agentTOTAL60.00

[0031] The tablets were prepared as follows.

[0032] The solid ingredients, excluding magnesium stearate and talc, were granulated in a mixed alkanol / water solvent system. To this end, the active ingredient was suspended in alkanol, and the colorant was dissolved in water. These two components were mixed together to form a uniform alkanol / water suspension that was added to the dry powder mixture during the granulation process. The granules were dr...

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Abstract

A pack contains medicinal tablets containing a phenothiazine derivative, prochlorperazine maleate, as active ingredient. The tablets are protected from damage by water. The pack is suitably a water-occlusive blister pack.

Description

PRIORITY CLAIM [0001] This application claims priority to British Patent Application Serial No. 0600075.6 filed on Jan. 4, 2006, the entire contents of which is hereby incorporated herein by this reference. TECHNICAL FIELD [0002] This invention relates to a pack of medicinal tablets, in particular, to a pack of medicinal tablets containing a phenothiazine derivative, for example, prochlorperazine maleate, as active ingredient. BACKGROUND [0003] An existing product containing prochlorperazine maleate is BUCCASTEM (trade mark), a product sold to combat nausea, vomiting, vertigo and migraine. [0004] We have discovered unexpectedly that in a traditional PVC / PVdC blister pack having tablets containing prochlorperazine maleate as the active ingredient, the stored tablets may be affected by moisture. Blister packs themselves are known (see, e.g., U.S. Pat. No. 4,612,755 to Cavanagh and U.S. Pat. No. 5,405,011 to Haber et al., the contents of the entirety of both of which are incorporated h...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B65D1/09
CPCA61J1/035A61K9/2018A61K9/205A61K31/5415
Inventor CAIRNS, GRAHAMHYDE, NEILKNOWLES, ANDREWMILLER, KERRY-ANNE
Owner ALLIANCE PHARMA LTD