Compositions and methods for promoting neural regeneration

a neural regeneration and composition technology, applied in the field of tissue regeneration, can solve the problems of not being able to grow new neurons or generate new axons, not being able to directly identify multipotential cells, and not being able to define the mechanisms, so as to improve learning and memory function. the effect of recovery
US20080070963A1Inactive Publication Date: 2008-03-20NEUBERGER TIMOTHY +2
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NEUBERGER TIMOTHY
Publication Date
2008-03-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene, as well as various analogues and derivatives of these compounds; (ii) one or more cells harvested from an animal or organism subsequent to the administration of a composition comprising a compound of (i); or (iii) any combination of (i) and (ii). The invention can be useful in treating decreases in neuronal function, for example from injury or disease.
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Description

[0001] The present invention relates to promoting tissue regeneration, such as neural tissue or liver tissue regeneration. More specifically, the present invention employs (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene.

[0002] The nervous system consists essentially of two categories of cells, neurons and glial cells. During neuronal development, immature nerve cell bodies migrate along glial cells to a location in the brain, where neurite processes (dendrites and axons) grow out from the nerve cell body. A growth cone at the tip of each process guides the path taken by each process, determining the path of neuron growth. A number of factors influence the path of neuron growth, including nerve growth factor (NGF) and local contact with cell-cell adhesion molecules, contact with extracellular matrix molecules and various other forms of chemotactic guidance. Cell-cell adhesion molecules th...

Claims

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