40 results about "Thioxanthenes" patented technology

The invention belongs to the technical field of organic photoelectric materials, and discloses a spiro-di-thioxanthene-based small-molecule luminescent material and preparation and application thereof. With spiro-di-thioxanthene nucleuses as framework units, and by changing connecting units at both sides of each spiro-di-thioxanthene nucleus and the number of the spiro-di-thioxanthene nucleuses, the molecular weight, Pi conjugacy and intramolecular charge transfer properties of the small-molecule luminescent material disclosed by the invention can be regulated. A spiro-structure therein can adjust the packing method among molecules. The preparation method of the material disclosed by the invention obtains a target compound with diphenyl sulfide and thioxanthone as original reaction materials by a series of simple reactions. The material structure is uniform, and the molecular weight is determined, and the spiro-di-thioxanthene-based small-molecule luminescent material has good solubility and film-forming property in common solvents. The spiro-di-thioxanthene-based small-molecule luminescent material can be applied as a hole transport material, an electron transport material and a luminescent material in OLED (Organic Light Emitting Diode) devices to improve the performance of the devices, and has profound significance for the development of high-performance devices.

The invention belongs to the technical field of photoelectric materials, and particularly relates to luminescent materials based on thioxanthene-fluorene spiral structures and organic photoelectric devices adopting the materials as luminescent layers. The luminescent materials adopts the thioxanthene-fluorene spiral structures as skeleton units. Intermediates are prepared through Ullmann reactions, and then the target compounds are obtained through Ullmann reactions or Suzuki reactions. The materials are single in structure and definite in molecular weight. The spiral structures of the materials can adjust an intermolecular accumulation manner, thus effectively inhibiting exciplex luminescence. The materials have deep meaning for development of high-effect devices. The organic photoelectric devices adopting the materials as the luminescent layers have good luminescent properties and can be used for small organic molecule light emitting diodes.

A holographic recording medium includes a recording layer. The recording layer includes a framework being expressed with the following general formula (1),In the above formula (1), Ar represents a substituted or unsubstituted group selected from benzothiophene group, naphthothiophene group, dibenzothiophene group, thienothiophene group, dithienobenzene group, benzothiazole group, naphthothiazole group, benzoisothiazole group, naphthoisothiazole group, phenothiazine group, phenoxathiin group, dithianaphthalene group, thianthrene group, thioxanthene group, and bithiophene group. In addition, n is an integer from 1 to 4.

The invention belongs to the technical field of electroluminescent materials, and discloses a compound containing 9,9-spiral thioxanthene as well as a preparation and application. The compound containing 9,9-spiral thioxanthene has the structural formula represented by formula 1 or formula 2, wherein R1 and R2 are the same or different electron-donating vinylene group, ethynylene group, aromatic ring composed of carbon and hydrogen atoms, aromatic heterocyclic ring composed of carbon, nitrogen and hydrogen atoms, aromatic heterocyclic ring composed of carbon, nitrogen, oxide and hydrogen atoms, aromatic heterocyclic ring composed of carbon, sulfur and hydrogen atoms, and aromatic heterocyclic ring composed of carbon, silicon and hydrogen atoms, C1-C24 alkyl group, alkyl-substituted conjugated unit, alkoxy-substituted conjugated unit or conjugated unit in which an alkyl group and an alkoxy group are simultaneously substituted; X is a carbon atom, a nitrogen atom, a sulfur atom, a silicon atom, an oxygen atom, carbonyl or phosphorus atom group. The compound obtained by the invention has fluorescence, and is as the light-emitting layer of an organic electroluminescent diode that can significantly improve the external quantum efficiency of the device. (The formulas are shown in the description).

The invention relates to a wear-resistant UV (ultraviolet) photocuring paint which is prepared from the following raw materials in parts by weight: 30-35 parts of high-functionality aliphatic polyurethane acrylic resin, 4-6 parts of brown fused alumina powder, 13-18 parts of 2-methyl methacrylate, 4-7 parts of isoprene, 5-9 parts of polylactic acid, 2-4 parts of sodium silicate, 2-4 parts of isopropyl thioxanthene ketone, 2-3 parts of liquid rosin resin, 3-5 parts of ricinoleic acid, 2-4 parts of propenyl glycidol ether and 4-6 parts of assistant. By adding the brown fused alumina powder, the wear resistance and flame retardancy of the UV (ultraviolet) photocuring paint are enhanced, and the cost of the paint is lowered; and the paint has the advantages of high crosslinking and curing speed, uniform film formation, high strength, favorable toughness, favorable water resistance and favorable binding property. The assistant enhances the dispersivity of the paint, so that the UV (ultraviolet) photocuring paint has favorable leveling property and the coating formed by the piant is smooth and bright.

The present invention provides a photocurable and thermosetting resin composition having excellent surface curability and deep curability, allowing pattern formation with a laser beam having a wavelength of 350 to 410 nm, and being useful as a solder resist for laser direct imaging, the composition including a carboxylic resin (A), an oxime ester-based photopolymerization initiator (B) such as 2-(acetyloxyiminomethyl)thioxanthene-9-one, and another photopolymerization initiator than (B) such as 2,4,6-trimethylbenzoyl-diphenyl-phosphine oxide, and a sulfur compound (E) such as 2-mercaptobenzothiazole.

The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene, as well as various analogues and derivatives of these compounds; (ii) one or more cells harvested from an animal or organism subsequent to the administration of a composition comprising a compound of (i); or (iii) any combination of (i) and (ii). The invention can be useful in treating decreases in neuronal function, for example from injury or disease.

The invention relates to flupentixol and melitracen tablets and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The flupentixol and melitracen tabletsare prepared from, by mass, 0.3-1.0% of flupentixol dihydrochloride, 5.78-19.26% of melitracen hydrochloride, 0.01-10% of an antioxidant, 60-88% of a filler, 0.5-6% of a disintegrating agent, 2-6% ofan adhesive and 0.2-3% of a lubricant. According to the flupentixol and melitracen tablets, by adding the antioxidant, the stability of the flupentixol and melitracen tablets can be effectively enhanced, flupentixol can be effectively controlled to be degraded to generate impurities such as Lu28-159 and trifluoromethyl thiodone, the impurity level is lowered, and product safety and effectiveness are guaranteed; the flupentixol and melitracen tablets prepared through the method has the similar in-vitro dissolution behavior and bioequivalence as original tablets Deanxit.

The invention belongs to the technical field of photoelectric materials and particularly relates to an organic small molecular material based on spiro thioxanthene and an organic photoelectric device using the material as a light emitting layer. By using spiro thioxanthene as a framework unit, the organic small molecular material can be used for obtaining a target compound by virtue of friedel craft reaction and Ullmann reaction. The material is single in structure and certain in molecular weight and has good solubility and film forming property in common solvents. The spiro structure of the material can adjust the accumulation mode of molecules, so that an exciplex is effectively prevented from emitting light, therefore, the material is of profound significance in development of high-effect devices. The photoelectric device using the material as the light emitting layer has a good light emitting performance and can be applied to organic small molecular light emitting diodes.

Described are articles, laminates, sheets, coatings, retroreflective articles, pigments containing thioxanthone compounds that are fluorescent colorants.

A synthesis method of metixene hydrochloride relates to a synthesis process of an antiparkinsonian drug. The synthesis method comprises the following steps: taking thiosalicylic acid as a raw material to obtain 2-thiophenyl benzoic acid by coupling with iodobenzene; then dehydrating and cyclizing to obtain 9-thioxanthone; reducing a carbonyl to obtain thioxanthene; and finally allowing the thioxanthene to react with 3-chloromethyl-1-pipecoline to obtain the target product (5) metixene hydrochloride shown as a formula (5) below. The synthesis method has the advantages of available raw materials, low cost, short preparation course, simple operation and easy industrialization, and helps produce the metixene hydrochloride which is the antiparkinsonian drug.

A durable colored article having fluorescent properties comprises a substantially solventless polyvinyl chloride matrix, a thioxanthene fluorescent dye, and a secondary or tertiary hindered amine light stabilizer having a molecular weight less than about 1000 grams / mole. The invention has the advantage in that it provides a flexible polyvinyl chloride film that exhibits durable fluorescent colors.

The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and / or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.

The invention provides an alkali-developed paste composition which is applicable to a laser direct imaging device using an active energy radiation with the maximum wave length of 350nm to 420nm, with the advantages of being beneficial for effectively forming a fine black matrix pattern and excellent disperse stability. The invention is characterized by comprising (A) carboxyl-included resin, (B)glass powders, (C) black paints, (D) a compound with at least one free radical polymerizability unsaturated radical, (E-1) NDM series photopolymerization evocating agent such as 2-(acetoxyl group imido group methyl) thioxanthene-9-keton, and (F) aluminum compound.

A durable colored article having fluorescent properties comprises a substantially solventless polyvinyl chloride matrix, a thioxanthene fluorescent dye, and a secondary or tertiary hindered amine light stabilizer having a molecular weight less than about 1000 grams / mole. The invention has the advantage in that it provides a flexible polyvinyl chloride film that exhibits durable fluorescent colors.

The invention belongs to the field of chemistry, and relates to a synthetic method of asymmetrical thioether. The synthetic method comprises the following steps of (a) under the condition of catalysis of tetrabutyl ammonium halide, enabling a structural compound as shown in a formula (I), a structural compound as shown in a formula (II) and sulfur oxonium salt to react in a solvent so as to obtain the asymmetrical thioether with a structure as shown in formula (III), wherein R1 is selected from phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl, or substituted thienyl; R2 is selected from hydrogen, phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl or substituted thienyl; or R1, R2 and C connected with R1 and R2 form fluorene or thioxanthene; R3 is selected from hydrogen or an alkyl group; R4 is selected from hydrogen, phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl or substituted thienyl; R5 is selected from hydrogen; or R4, R5 and C connected with R4 and R5 form the fluorene or the thioxanthene; R6 is selected form the alkyl group or the substituted alkyl group; and X is selected from C1, Br or I.

The invention discloses xanthone Schiff base modified graphene quantum dots CPCG as well as a preparation method thereof and application in preparing a sodium glutamate detection reagent. The preparation method is characterized by introducing the xanthone Schiff base into nano quantum dots which are strong in water solubility, specifically for example, introducing Schiff base which is synthesizedby enabling 1-chloro-4-propoxy thioxanthene-9-ketone to react with chitosan to the graphene quantum dots, thus obtaining the xanthone Schiff base modified graphene quantum dots which are strong in water solubility and high in sodium glutamate selectivity. A synthesis method of the xanthone Schiff base modified graphene quantum dots is simple, the conditions are mild, a product can be easily obtained, a good effect can be obtained by applying the compound to sodium glutamate detection, and the compound cannot be affected by other conventional symbiotic biomolecules such as matters of glycine, arginine, methionine, glucose, glucosamine and the like, and high selectivity is obtained; a fluorescence spectrophotometer is convenient to operate, and a fluorescent signal of a sample is obvious.

The invention provides an alkali-developed paste composition which is applicable to a laser direct imaging device using an active energy radiation with the maximum wave length of 350nm to 420nm, with the advantages of being beneficial for effectively forming a fine black matrix pattern and excellent disperse stability. The invention is characterized by comprising (A) carboxyl-included resin, (B) glass powders, (C) black paints, (D) a compound with at least one free radical polymerizability unsaturated radical, (E-1) NDM series photopolymerization evocating agent such as 2-(acetoxyl group imido group methyl) thioxanthene-9-keton, and (F) aluminum compound.

The present invention is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for treatment of infectious diseases. The invention furthermore relates to compositions comprising said anti-infective agents.

The invention provides a preparation method of flupentixol dihydrochloride, which comprises the following steps: reacting and dehydrating 10-hydroxy-10-(3-dimethylaminopropyl)-2-trifluoromethyl thioxanthene and sulfoxide chloride or acetic anhydride to prepare high-content Z-type 10-[3-(EZ)-dimethylaminopropyl]-2-trifluoromethyl thioxanthene, reacting with N-hydroxyethyl piperazidine to prepare flupentixol base, and finally, introducing sufficient hydrochloric acid gas into the flupentixol base to prepare the high-content Z-type flupentixol dihydrochloride. The method has the advantages of fewer steps, high yield and high product purity, is simple to operate, and does not use any extremely toxic substance to pollute the environment. The Z-type flupentixol dihydrochloride content in the flupentixol dihydrochloride prepared by the method is 42-52%, and conforms to the quality standard specification for flupentixol dihydrochloride in European Pharmacopoeia.

The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene, as well as various analogues and derivatives of these compounds; (ii) one or more cells harvested from an animal or organism subsequent to the administration of a composition comprising a compound of (i); or (iii) any combination of (i) and (ii). The invention can be useful in treating decreases in neuronal function, for example from injury or disease.

The invention provides a naphtho-thioxanthene derivative as well as a preparation method and application thereof, belonging to the technical field of organic optoelectronic materials. The material takes naphtho-thioxanthene groups as a center for connecting two conjugate non-planar structures, thus having good electron transmission ability and greatly improving luminous efficiency; therefore, the material can be used for preparing an organic light-emitting device (OLED), and more particularly, the OLED taking the material as an electron transport material or a light-emitting layer main body material is superior to the existing commonly-used OLED. The invention also provides the preparation method of the naphtho-thioxanthene derivative; the preparation method is simple, thus being suitable for industrial production.

A method of mono-therapeutically treating a patient suffering from a condition selected from naïve schizophrenia, therapy resistant schizophrenia, therapy refractory schizophrenia, therapy resistant depression, chronic depression, recurrent depression, and resistant bipolar disorder comprises the administration of a pharmacologically effective amount of a thioxanthene, such as chlorprothixene, flupenthixol, thiotixene, zuclopenthixol, zuclopenthixol acetate and zuclopenthixol decanoate, including a pharmaceutically acceptable salt thereof. Also disclosed is a corresponding use and the manufacture of a corresponding medicament.

A thioxanthone ring system derivative compound is provided. The thioxanthone ring system derivative compound is represented by a formula (I):wherein X is a substituent being one selected from a group consisting of halogens, wherein R1 is a substituent being one selected from a group consisting of sulfur and sulfur dioxide, wherein R2 is a substituent being one selected from a group consisting of C1˜C10 alkyl group, C3˜C10 branched alkyl group, C3˜C10 cyclic alkyl group, phenyl group, phenyl alkyl group, and wherein hydrogen of phenyl group can be partially substituted by halogens, alkoxyl group, C1˜C10 alkyl group, nitro group or amine group.

The invention discloses a synthesis method of a 9H-xanthene / thioxanthene compound. The 9H-xanthene / thioxanthene compound is obtained by dissolving a compound of a formula (I) and benzene substitutedby an electron-donating group with a solvent and then enabling reaction under the action of a water removing agent and a catalyst, and the 9H-xanthene / thioxanthene compound has a molecular structureshown by a formula (III), wherein Z represents an oxygen atom or a sulfur atom, R represents an aryl group substituted by an electron donating group. The synthesis method does not need metal catalysis, halogen addition, peroxide addition or high-temperature reaction conditions, is simple in reaction condition, high in yield and low in waste emission, is an environment-friendly method and is beneficial to energy conservation and environmental protection, reaction devices are simple, and industrial production is facilitated.

The invention relates to a flupenthixol melitracen tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The flupentixol melitracen tablet of the present invention comprises the following components in mass percentage: 0.3% to 1.0% of flupentixol hydrochloride, 5.78% to 19.26% of melitracen hydrochloride, and 0.01% to 10% of antioxidant %, filler 60%-88%, disintegrant 0.5%-6%, binder 2%-6%, lubricant 0.2%-3%. The flupenthixol melitracen tablet of the present invention can effectively enhance the stability of the flupenthixol melitracen tablet by adding an antioxidant, and can effectively control the degradation of flupentixol to produce Lu28‑159, Impurities such as trifluoromethylthioxanthone reduce the level of impurities and ensure product safety and effectiveness; flupentixol and melitracen tablets prepared according to the present invention have similar in vitro dissolution behavior and biological properties as the original tablet Deanxit. equivalence.

The invention belongs to the technical field of photoelectric materials, and in particular relates to a luminescent material based on a thioxanthene-fluorene spiro structure and an organic photoelectric device using the material as a luminescent layer. The luminescent material uses a thioxanthene-fluorene spiro structure as a skeleton unit, prepares an intermediate through Ullmann reaction, and then obtains a target compound through Ullmann reaction or Suzuki reaction. This type of material has a single structure and a definite molecular weight; the spiral structure of the material of the present invention can adjust the packing mode between molecules, thereby effectively suppressing the light emission of exciplexes, which has far-reaching significance for the development of high-performance devices; The organic photoelectric device of the layer has good light-emitting performance and can be applied to organic small molecule light-emitting diodes.

The invention relates to wear-resistant ink capable of realizing three-dimensional printing and a printing method thereof. The wear-resistant ink comprises the following components in parts by mass: 30-65 parts of a first component, 25-60 parts of a second component, 1-5 parts of N-vinyl pyrrolidone, 1-8 parts of an adhesion promoter and 1-10 parts of modified organic silicon, wherein the first component comprises pentaerythritol triacrylate and trimethylolpropane triacrylate, and the second component comprises isopropyl-9H-thioxanthen-9-one, 1-hydroxycyclohexyl phenyl ketone and triphenyl phosphate. The wear-resistant ink provided by the invention is strong in stereoscopic printing impression, can achieve 2-to-3-mm-high effect through one-time printing, can endure 100 or more CS-10 grinding wheel friction tests, and is good in adhesive force, excellent in stereoscopic effect and extremely good in friction-resistant effect after being printed on various materials such as mylar, PET, PC and the like.

The invention relates to a flupentixol melitracen pharmaceutical composition and a preparation thereof, belonging to the technical field of pharmaceutical preparations. The pharmaceutical composition of flupentixol and melitracen of the present invention comprises flupentixol hydrochloride, melitracen hydrochloride and an antioxidant. The flupenthixol melitracen pharmaceutical composition of the present invention can effectively enhance the stability of the flupenthixol melitracen compound preparation by adding an antioxidant, and can effectively control the degradation of flupentixol to produce Lu28-159 , trifluoromethylthioxanthone and other impurities, reduce the level of impurities, and ensure product safety and effectiveness; flupentixol and melitracen tablets prepared according to the present invention have similar in vitro dissolution behavior and Bioequivalence.