Sesamol Derivatives as Novel Inhibitors of Arachidonic Acid Formation

a technology of arachidonic acid and derivatives, which is applied in the direction of drug compositions, metabolic disorders, cardiovascular disorders, etc., can solve the problems of difficult synthesizing, potential toxicity of sesamol, and toxicity of sesame lignans, so as to reduce or completely eliminate the toxicity of sesamol
US20090012157A1Inactive Publication Date: 2009-01-08SEARS BARRY D
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SEARS BARRY D
Publication Date
2009-01-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel class of inhibitor of arachidonic acid useful for treating inflammatory conditions. Specifically, the invention relates to hydrophobic and hydrophilic derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.
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Description

FIELD OF INVENTION

[0001] The invention relates to compositions and methods for treating, moderating, and preventing inflammation. Specifically, the invention relates to compositions useful for inhibiting the formation of arachidonic acids, which are precursors of pro-inflammatory eicosanoids. The invention also relates to methods of preparing and administering such compositions.BACKGROUND OF THE INVENTION

[0002] It is becoming increasingly recognized that increased inflammation is strongly associated with, if not the underlying cause of, many disease conditions including obesity, type 2 diabetes, cancer, heart disease, and neurological conditions such as multiple sclerosis and Alzheimer's disease.

[0003] It has been shown that the regulation of certain eicosanoids, a class of biologically active metabolites, can help control inflammation. While many anti-inflammatory drugs directly target the production of pro-inflammatory eicosanoids, e.g., by inhibiting the enzyme required in their pro...

Claims

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