External Preparation for Athlete's Foot Treatment

Abstract

External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rubefaction, comprising an anti-trichophyton drug mixed with at least one compound selected from among 1-menthol, menthol analogue compounds and bactericidal compounds.

Description

[0001]This patent application is a continuation of U.S. application Ser. No. 10 / 561,499, filed Dec. 19, 2005, which is the National Stage of International Application No. PCT / JP2004 / 008992, filed Jun. 25, 2004, which claims the benefit of priority from Japanese Application No. 2003-407136, filed Dec. 5, 2003 and Japanese Application No. 2003-181264, filed Jun. 25, 2003, teachings of each of which are herein incorporated by reference in their entirety.TECHNICAL FIELD[0002]The invention relates to an external preparation for athlete's foot treatment, comprising an anti-trichophyton drug and at least one compound, which is selected from l-menthol, menthol analogue compounds and bactericidal compounds, as an essential ingredient.BACKGROUND ART[0003]As an anti-fungal agent used for an external preparation for athlete's foot treatment, various antifungal agents such as imidazole, triazole, thiocarbamic acid, benzylamine, allylamine and morpholine types have been developed and have been on...

AI Technical Summary

Benefits of technology

[0030]Consequently, in an anti-trichophyton drugs of which antibacterial action against fungi except Trichophyton is not necessarily satisfactory, the external preparation for athlete's foot treatment of the invention suppresses the growth of skin habitual fungi such as Staphylococus aureus and Candida albicans, which become a cause of a bad smell of foot due to athlete's foot, aggravation athlete's foot and the like, without combination of an antifungal agent, and not only improves a therapeutic effect for athlete's foot compared with a case simply to reduce Trichophyton but has effect to enhance patient's compliance.

[0046]The formula in which dibucaine hydrochloride, cholorpheniramine maleate and glycyrrhetinic acid are blended for an external preparation for athlete's foot treatment consisting of butenafine hydrochloride and l-menthol is particularly preferable because it can synergistically enhance the compliance.

Problems solved by technology

In addition, although a composition with a strengthened antifungal activity is also reported, in which an allylamine type antifungal agent and menthol are blended, this increases the activity against so called Trychophyton and does not strengthen the antifungal activity against other fungi such as Candida albicans (ex. see Patent document 4).

Further, although there are a preparation in which a peripheral vasodilator is added to an antifungal agent (ex. see Patent document 5) and a preparation in which an antifungal agent is added with a substance such as methyl salicylate, glycol salicylate, crotamitone, peppermint oil or l-menthol to improve a horny layer accumulation of the antifungal agent (ex. see Patent document 6), they do not show any excellent antifungal property against Trychophyton and other fungi including Candida albicans and the like.

In addition, any external preparation disclosed in the above documents did not suppress the growth of skin habitual bacteria such as Staphylococus aureus and did not have effects in a case that the skin habitual bacteria such as Candida albicans and Staphylococus aureus, which accelerated the discomfort of athlete's foot (itch, bad smell, etc.), grew abnormally, therefore, it could not be said that it satisfactorily enhanced patient's compliance after applying such external preparation described above.