Packaging Solutions

a technology for packaging solutions and ophthalmic devices, applied in the directions of transportation and packaging, liquid handling, closures using stoppers, etc., can solve the problems of reducing shelf life and/or adverse reactions, limited the use of surfactants in packaging solutions, and many people who wear contact lenses still experience dryness or eye irritation, so as to preserve the sterility of solution and ophthalmic devices, and improve the lubricity of lenses

Inactive Publication Date: 2009-07-09
LAI YU CHIN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020](c) a container for holding the solution and ophthalmic device sufficient to preserve the sterility of the solution and ophthalmic device, wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.
[0021]The aqueous packaging solutions of the present invention containing at least a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers is believed to provide a more uniform coating on the surface of an ophthalmic device such as a contact lens thereby resulting in improved lubricity of the lens. Thus, the lens will be more comfortable to wear in actual use and would allow for the extended wear of the lens without irritation or other adverse effects to the cornea.

Problems solved by technology

Furthermore, the difficulties of adding a surfactant to a packaging solution, including the possibility of lowering shelf-life and / or adverse reactions during heat sterilization, have further limited the use of surfactants in a packaging solution for the purpose of providing any possible or marginal effect on lens comfort.
Nevertheless, many people who wear contact lenses still experience dryness or eye irritation throughout the day and particularly towards the end of the day.
An insufficiently wetted lens at any point in time will cause significant discomfort to the lens wearer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0101]Synthesis of Poly(glyceryl methacrylate-co-octafluoropentyl methacrylate) (“P(GM-co-OFPMA)”).

[0102]To a three-neck 500 liter flask equipped with condenser and nitrogen inlet tube was added glyceryl methacrylate (9.724 g; 60.711 mmol), THF (200 ml), 1H, 1H, 5H-octafluropentyl methacrylate (4.481 g; 14.927 mmol), and AIBN (0.214 g; 1.303 mmol). The contents were bubbled vigorously with nitrogen for 20 minutes and then heated to reflux under the constant nitrogen flow overnight. A white product precipitated on the second day. The product was recovered by removal of solvent.

example 2

[0103]Preparation of lens.

[0104]Monomer mixtures are made by mixing the following components listed in Table 1, at amounts per weight.

TABLE 1Amount inIngredientweightID2S4H11TRIS35DMA10NVP40HEMAVC13-methoxy-1-butanol4Vazo-640.5Glycidyl methacrylate5IMVT150 ppm

The resultant monomer mixtures are cast into contact lenses by introducing the monomer mixture to a mold assembly composed of a PP mold for the anterior surface and a PP mold for the posterior surface and thermally curing the monomer mixture at 100° C. for 2 hours. The contact lenses are released from the molds.

example 3

[0105]An aqueous packaging solution containing 1% by weight of the copolymer of Example 1 dissolved in a borate buffered saline at a pH of 7.2 is placed in a polypropylene blister package. Next, the lenses of Example 2 are immersed in the aqueous packaging solution in the polypropylene blister package. The package is sealed with foil lidstock and then autoclaved for 1 cycle.

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Abstract

Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.

Description

[0001]This application claims the benefit of provisional patent application No. 61 / 019,863 filed on Jan. 9, 2008 which is incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]1. Technical Field[0003]The present invention generally relates to packaging solutions for ophthalmic devices such as contact lenses.[0004]2. Description of Related Art[0005]Blister-packs and glass vials are typically used to individually package each soft contact lens for sale to a customer. Saline or deionized water is commonly used to store the lens in the blister-packs, as mentioned in various patents related to the packaging or manufacturing of contact lenses. Because lens material may tend to stick to itself and to the lens package, packaging solutions for blister-packs have sometimes been formulated to reduce or eliminate lens folding and sticking. For this reason, polyvinyl alcohol (PVA) has been used in contact-lens packaging solutions.[0006]It has been stated that if a lens is thoroughly ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A45C11/04B65B55/02
CPCA45C11/005A61L12/04C08F220/28C08F220/24B65B25/008C08F220/282
Inventor LAI, YU-CHINLANG, WEIHONG
Owner LAI YU CHIN
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