2-acylaminothiazole derivative or salt thereof

a technology of acylaminothiazole and derivative, applied in the field of new acylaminothiazole derivative, can solve the problems of insufficient amount of platelets, difficult to sufficiently improve thrombocytepenia, and inability to provide sufficient platelets, etc., and achieve the effect of increasing the number of platelets
US20100222329A1Inactive Publication Date: 2010-09-02ASTELLAS PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2010-09-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba / F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a novel 2-acylaminothiazole derivative or a salt thereof, which is useful as a medicament particularly in the treatment of thrombocytopenia, and pharmaceutical composition comprising the compound as an active ingredient.BACKGROUND ART

[0002] A platelet is a nuclear blood cell playing an important role in physiological hemostasis and pathological thrombosis, and is continuously produced from megakaryocytes in a living organism. The platelet originates from pluripotent stem cells like other blood cells. Specifically, the pluripotent stem cell becomes a megakaryocytic progenitor cell, from which megakaryoblasts, promegakaryocytes, and megakaryocytes are formed. During the maturation of a megakaryocyte, premature megakaryocytes only carry out DNA synthesis without involving cell division to become a polyploid. Thereafter, cytoplasm begins to mature to form a platelet separation membrane, and a platelet is released by cytoplasm fragment...

Claims

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