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Hyaluronic acid derivative and drug containing the same

a technology of hyaluronic acid and derivatives, which is applied in the direction of biocide, drug composition, transportation and packaging, etc., can solve the problems of short time period for continuing the effect of nsaids and the method not becoming a basic remedy for arthritis

Inactive Publication Date: 2011-04-14
SEIKAGAKU KOGYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0035]According to the present invention, hyaluronic acid derivatives in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, particularly a non-steroidal anti-inflammatory drug-introduced hyaluronic acid derivative in which a non-steroidal anti-inflammatory drug is bound through a covalent bond (hereinafter referred to as “substance 1 of the present invention”), also a disease-modifying anti-rheumatic drug-introduced hyaluronic acid derivative in which a disease-modifying anti-rheumatic drug is bound through a covalent bond (hereinafter referred to as “substance 2 of the present invention”, in this connection, the substance 1 of the present invention and the substance 2 of the present invention are also called “substance of the present invention” as a whole), and a pharmaceutical agent which comprises one of these derivatives as the active agent (hereinafter referred to as “pharmaceutical agent of the present invention”) are provided. Since the substance of the present invention is sufficiently dissolved in a buffer, saline, water for injection or the like which is used as the solvent of injections or the like, it can be used as an injection that can be directly administered to the affected site. In addition, the pharmaceutical agent of the present invention can be used in the treatment of arthritis, suppression of inflammation and suppression of pain, and its parenteral administration or topical administration as injections (e.g., intraarticular administration) is also possible.

Problems solved by technology

A method in which the problematic point as gastrointestinal adverse effects caused by the oral administration of NSAIDs is avoided by direct injection NSAIDs into the affected site can be considered Although theoretically, but for example, when NSAIDs are directly injected into the knee joint cavity, the period of time for continuing the effect of NSAIDs is short due to quick absorption, so that such a method is not adopted.
In addition, since NSAIDs themselves aim at alleviating or suppressing pain, such a method does not become a basic remedy for arthritis.

Method used

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  • Hyaluronic acid derivative and drug containing the same
  • Hyaluronic acid derivative and drug containing the same
  • Hyaluronic acid derivative and drug containing the same

Examples

Experimental program
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examples

[0146]The present invention is described below more specifically based on Examples. However, there is no intention to limit the technical scope of the present invention by this.

[0147]In this connection, all of the hyaluronic acid and sodium hyaluronate used in the following Examples were purchased from Seikagaku Corporation.

[0148]Hereinafter, as the phosphate buffered saline (PBS), 5 mM PBS was used in the following Examples, unless otherwise indicated.

production examples

Reference Example 1

Synthesis of t-butoxycarbonyl-aminopropanol (Boc-NH(CH2)3OH) (Boc-aminopropanol)

[0150]In 10 ml of dichloromethane, 1.542 g (20.5 mmol) of aminopropanol was dissolved, and 10 ml of a 4.484 g (20.5 mmol) di-t-butyl dicarbonate (Boc2O) / dichloromethane solution was slowly added dropwise thereto under ice-cooling. Thereafter, the reaction solution was returned to room temperature and stirred for 2 hours and 40 minutes, disappearance of the starting materials was confirmed by thin layer chromatography (TLC), and then dichloromethane was evaporated under reduced pressure. The reaction quantitatively progressed, and an oily substance was obtained at a yield of 3.92 g. The structure was identified by 1H-NMR (CDCl3).

[0151]1H-NMR (500 MHz, CDCl3) δ (ppm)=1.46 (9H, s, Boc), 1.66 (2H, quant, —NHCH2CH2CH2O—), 3.27 (3H, m, —NHCH2CH2CH2O—), 3.66 (2H, m, —NHCH2CH2CH2O—), 4.91 (1H, br, CH2OH)

example 1

Synthesis of Aminopropanol-Ketoprofen Hydrochloride

1) Synthesis of Boc-Aminopropanol-Ketoprofen

[0152]In 14 ml of dichloromethane, 2.371 g (13.5 mmol) of Boc-aminopropanol and 3.441 g (13.5 mmol) of ketoprofen (manufactured by Tokyo Kasei Kogyo) were dissolved, and 323 mg (2.6 mmol) of 4-dimethylaminopyridine (DMAP) and 2.833 g (14.8 mmol) of water-soluble carbodiimide hydrochloride (WSCI.HCl) / 14 ml dichloromethane were added thereto in this order under ice-cooling. After returning to room temperature and stirring overnight, dichloromethane was evaporated under reduced pressure, and ethyl acetate was added thereto, followed by separation by washing with 5% citric acid twice, water, 5% sodium hydrogen carbonate twice, water and saturatedbrine consecutively. After dehydration drying with sodium sulfate, ethyl acetate was evaporated under reduced pressure to give 5.430 g of the titled compound (yield 98%). The structure was identified by 1H-NMR (CDCl3).

[0153]1H-NMR (500 MHz, CDCl3) δ (p...

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Abstract

A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof.

Description

TECHNICAL FIELD[0001]The present invention relates to hyaluronic acid derivatives to which a non-steroidal anti-inflammatory drug or a disease-modifying anti-rheumatic drug is introduced via a spacer which is biodegradable, and production methods thereof.BACKGROUND ART[0002]A sodium hyaluronate solution is used as a therapeutic agent for arthritis such as osteoarthritis of knee (OA) or rheumatoid arthritis of knee (RA). The sodium hyaluronate solution is generally used as injections by the direct administration to the affected knee joints, and shoulder joints, and frequently used for the purpose of improving functional disorders and suppressing pain caused by the arthritis.[0003]Non-steroidal anti-inflammatory drugs (hereinafter also referred to as “NSAIDs” or “NSAID”) and disease-modifying anti-rheumatic drugs (hereinafter also referred to as “DMARD”), which improve morbid states such as articular rheumatism, are also used as agents for suppressing or alleviating pains caused by su...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/728C08B37/08A61P29/00B65D69/00A61K9/08A61K31/192A61K31/196A61K31/405A61K31/5415A61K31/60A61K45/00A61K47/18A61K47/36A61K47/48A61P19/02A61P29/02
CPCA61K31/192A61K31/196A61K31/405A61K47/481A61K31/60A61K31/728A61K47/4823A61K31/5415A61K47/55A61K47/61A61P19/02A61P29/00A61P29/02C08B37/003
Inventor MIYAMOTO, KENJIYASUDA, YOUSUKEYOSHIOKA, KEIJI
Owner SEIKAGAKU KOGYO CO LTD
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