3 results about "Hyaluronan binding" patented technology

The present disclosure is directed to a method that involves selecting a subject having a primary tumor and obtaining, from the selected subject, a sample containing exosomes derived from primary tumor cells. The exosomes are isolated from the sample and expression levels of cell migration-inducing and hyaluronan-binding protein (CEMIP) are detected in the isolated exosomes.

This invention belongs to the field of contact lens technology, and provides a moisturizing protein-based contact lens and its preparation method. The preparation method includes the following steps: mixing a silk fibroin solution and a hyaluronic acid-binding protein solution to obtain a protein mixture solution; mixing a hydrophilic modification component, an oxygen-permeable modification component, and water to obtain a composite modifier; mixing the protein mixture solution, the composite modifier, and a crosslinking agent to obtain a pre-crosslinked mixture; molding the pre-crosslinked mixture and performing gradient crosslinking, followed by sequential soaking in buffer solution, rinsing, and sterilization to obtain the moisturizing protein-based contact lens. The contact lens of this invention uses protein as the main component, does not rely on silicon-based substances or harmful crosslinking agents, and possesses high biocompatibility, high oxygen permeability, suitable mechanical properties, and controllable degradation.

The invention discloses polypeptide type micromolecule glue and application thereof in preparation of cosmetics with a skin anti-aging effect. The polypeptide type small molecule glue comprises a hyaluronic acid binding peptide fragment and a proteoglycan binding peptide fragment. The polypeptide type small molecule glue provided by the invention is polypeptide with biological activity, the polypeptide can be combined with hyaluronic acid and proteoglycan after entering cells, the function of connecting the hyaluronic acid and the proteoglycan to protein 1 (HAPLN1) can be replaced, the content of collagen which is gradually reduced along with skin aging can be recovered to a certain extent, and the collagen type small molecule glue has the advantages of being good in biocompatibility, good in stability and good in stability. The composition may become a promising innovative strategy for preventing or repairing the aged skin.