11 results about "Hyaluronan binding" patented technology

Disclosed herein are hyaluronic acid (HA)-nimesulide conjugates having one or two disaccharide units.

The invention relates to the technical field of biomedicine, and provides an endometrial repair stent and a preparation method thereof.The endometrial repair stent is prepared by taking a flaky nanofiber composite membrane as a substrate, combining the flaky nanofiber composite membrane with modified hyaluronic acid, then conducting dynamic crosslinking with carboxymethyl chitosan and then conducting compounding with poly N-isopropylacrylamide; the mass ratio of the modified hyaluronic acid to the carboxymethyl chitosan to the poly (N-isopropylacrylamide) is (1-9): (1-9): (1-90); the thickness of the nanofiber composite membrane is 0.1-0.4 mm, and the nanofiber composite membrane can be applied to treatment of intrauterine adhesion. According to the endometrial repair stent, the nanofiber composite membrane and the temperature-sensitive hydrogel are combined, a uterine cavity is fully paved by utilizing the fluidity of the hydrogel, and the three-dimensional structure of the nanofiber can be used for orderly inducing a wound surface, so that the adhesion and proliferation of cells are facilitated, scar formation is reduced, the repair effect is ensured, and regeneration is promoted. The two parts are combined, so that the plasticity of the whole structure is enhanced, the supporting performance is improved, the indwelling time in the uterine cavity is long, and the double effects of repairing and isolating are fully achieved.

The invention discloses a preparation method of anti-tumor hyaluronic acid-naringenin self-assembled nanoparticles, and belongs to the field of medicines. According to the method, carboxyl on hyaluronic acid and hydroxyl on naringenin are combined to form an ester group, and the hyaluronic acid-naringenin polymer is obtained. Hydrophilic hyaluronic acid is combined with hydrophobic naringenin to form a hydrophilic and hydrophobic polymer, then under the action of ultrasonic waves in an aqueous solution, the hydrophobic end repels water molecules and is mutually gathered, and the hydrophilic end wraps the periphery of the hydrophobic end and is in contact with water, so that the structure that the core is hydrophobic naringenin and the core is hydrophobic naringenin is formed. The outer core is a nanoparticle of hydrophilic hyaluronic acid. The particle size of the nanoparticles is 140-200nm, the nanoparticles are stable and uniform, in-vitro release experiment results show that the nanoparticles can be slowly released, and cell experiments show that the preparation can obviously improve the toxicity of naringenin to tumor cells, which shows that the nanoparticles have good anti-tumor activity.

The invention provides a self-supplementing metabolism-enhanced synbiotic microsphere and preparation and application thereof, and belongs to the technical field of microbial medical preparations. Cyclopentadienyl norbornene hyaluronic acid (HA-NOR) and sulfhydrylation hyaluronic acid (HA-SH) are combined through thiol-ene click reaction, lactobacillus rhamnosus LGG is used as an active metabolism ecological niche, hyaluronic acid (HA) is used as an innovative prebiotic matrix capable of achieving self-supplementing, and the self-supplementing prebiotic composition is prepared. And the self-supplementing metabolism-enhanced synbiotics microspheres (SMASMs) are successfully prepared, so that the intestinal tract-skeleton metabolic balance is recovered. As a prebiotic preparation capable of enhancing metabolism, the oral microspheres disclosed by the invention can efficiently utilize probiotics to realize intestinal flora regulation and promote generation and metabolism of short-chain fatty acid, and can synergistically reconstruct intestinal-bone homeostasis by down-regulating an osteoclast signal channel, so that a patient with postmenopausal osteoporosis can be better treated; and the medicine curative effect is efficiently exerted through oral administration.

Provided herein are compositions including a functionalized particle, optionally a liposome and a peptide tethered to the liposome, wherein the peptide is selected from a triple-helix forming peptide (THFP), a hyaluronic acid binding peptide (HBAP), or a combination thereof. Also provided herein are methods of using the functionalized particles in increasing residence time of a therapeutic agent in a target treatment area for use in drug delivery and / or treating, eradicating, or inhibiting biofilm formation.

The present disclosure is directed to a method that involves selecting a subject having a primary tumor and obtaining, from the selected subject, a sample containing exosomes derived from primary tumor cells. The exosomes are isolated from the sample and expression levels of cell migration-inducing and hyaluronan-binding protein (CEMIP) are detected in the isolated exosomes.

The invention provides a composition containing keratinase. The composition is prepared from the following components: 5000 to 20000 U / g of keratinase, 2 to 10 wt% of calcium thioglycolate, 0.5 to 5 wt% of folium cortex eucommiae extract, 0.3 to 2 wt% of eucalyptus multibracteata essential oil, more than or equal to 70% of cineole and 0.05 to 1 wt% of hyaluronic acid binding peptide HABP. The composition is used for preparing the painless depilatory paste. The keratinase is innovatively compounded with the calcium thioglycolate and other components, so that the skin irritation is remarkably reduced while efficient hair removal is ensured, and the keratinase hair removal cream has the multiple advantages of long-acting hair inhibition, immediate repair, use experience improvement and the like.

The present invention relates to new hyaluronic acid binding proteins. The invention refers to new engineered fusion proteins for use in treating disorders of the eye or the joints. The fusion proteins comprise a subunit that specifically binds to hyaluronic acid. In addition to the hyaluronic acid binding protein, the new fusion proteins comprise a protein therapeutically effective in diseases of the eye or of joints. The fusion proteins are particularly well-suited for medical applications that require extended half-life of eye specific therapeutic proteins.

This invention belongs to the field of contact lens technology, and provides a moisturizing protein-based contact lens and its preparation method. The preparation method includes the following steps: mixing a silk fibroin solution and a hyaluronic acid-binding protein solution to obtain a protein mixture solution; mixing a hydrophilic modification component, an oxygen-permeable modification component, and water to obtain a composite modifier; mixing the protein mixture solution, the composite modifier, and a crosslinking agent to obtain a pre-crosslinked mixture; molding the pre-crosslinked mixture and performing gradient crosslinking, followed by sequential soaking in buffer solution, rinsing, and sterilization to obtain the moisturizing protein-based contact lens. The contact lens of this invention uses protein as the main component, does not rely on silicon-based substances or harmful crosslinking agents, and possesses high biocompatibility, high oxygen permeability, suitable mechanical properties, and controllable degradation.

The invention discloses polypeptide type micromolecule glue and application thereof in preparation of cosmetics with a skin anti-aging effect. The polypeptide type small molecule glue comprises a hyaluronic acid binding peptide fragment and a proteoglycan binding peptide fragment. The polypeptide type small molecule glue provided by the invention is polypeptide with biological activity, the polypeptide can be combined with hyaluronic acid and proteoglycan after entering cells, the function of connecting the hyaluronic acid and the proteoglycan to protein 1 (HAPLN1) can be replaced, the content of collagen which is gradually reduced along with skin aging can be recovered to a certain extent, and the collagen type small molecule glue has the advantages of being good in biocompatibility, good in stability and good in stability. The composition may become a promising innovative strategy for preventing or repairing the aged skin.

The present invention relates to the field of biomedical technology, and a kind of endometrial repair stent and preparation method thereof is provided, with sheet-like nanofiber composite membrane as substrate, first combined with modified hyaluronic acid, then after being dynamically cross-linked with carboxymethyl chitosan, and then composited with poly N-isopropyl acrylamide to obtain; the mass ratio of modified hyaluronic acid, carboxymethyl chitosan and poly N-isopropyl acrylamide is (1~9): (1~9): (1~90); the thickness of nanofiber composite membrane is 0.1~0.4mm, which can be applied to treat intrauterine adhesions. Endometrial repair stent combines nanofiber composite membrane with thermosensitive hydrogel, utilizes the fluidity of hydrogel to cover the uterine cavity, and the three-dimensional structure of nanofiber can orderly induce the wound surface, is beneficial to the adhesion and proliferation of cells, reduces scar formation, ensures repair effect, and promotes regeneration. The two are combined, and the plasticity of the overall structure can be enhanced, and supportiveness is increased. The retention time in the uterine cavity is long, and the dual effect of repair and isolation is fully achieved.