High performance selective light wavelength filtering providing improved contrast sensitivity

a selective light wavelength filtering and high-performance technology, applied in the field of ophthalmic systems, can solve the problems of blue light hazard, optical degradation of the lens or cataract, and exposure to the short wavelengths that pose the greatest danger, and achieve the effect of improving contrast sensitivity

Inactive Publication Date: 2012-03-29
ISHAK ANDREW W +7
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0036]According to the present invention, ophthalmic systems and coatings are described comprising a s

Problems solved by technology

The shorter wavelengths pose the greatest hazard because they inversely contain more energy.
Exposure to these wavelengths has been called the blue light hazard because these wavelengths are perceived as blue by the human eye.
In eyes without an intraocular lens (aphakic eyes), light with wavelengths shorter than 400 nm can cause damage.
In phakic eyes, this light is absorbed by the intraocular lens and therefore does not contribute to retinal photo toxicity; however it can cause optical degradation of the lens or cataracts.
This premature reversal increases the risk of oxidative damage and is believed to lead to the buildup of the pigment lipofuscin in the retina.
It is believed that the drusen then further interferes with the normal physiology/metabolic activity which allows for the proper nutrients to get to the photoreceptors thus contributing to age-related macular degeneration (AMD).
Drusen hinders or block the RPE layer from providing the proper nutrients to the photoreceptors, which leads to damage or even death of these cells.
To further complicate this process, it appears that when lipofuscin absorbs blue light in high quantities it becomes toxic, causing further damage and/or death of the RPE cells.
A2E has been shown to be maximally excited by blue light; the photochemical events resulting from such excitation can lead to cell death.
1) Waste buildup occurs within the pigment epithelial level starting from infancy through out life.
2) Retinal metabolic activity and ability to deal with this waste typically diminish with age.
3) The macula pigment typically decreases as one ages, thus filtering out less blue light.
4) Blue light causes the lip

Method used

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  • High performance selective light wavelength filtering providing improved contrast sensitivity
  • High performance selective light wavelength filtering providing improved contrast sensitivity
  • High performance selective light wavelength filtering providing improved contrast sensitivity

Examples

Experimental program
Comparison scheme
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example 1

[0192]A polycarbonate lens having an integral film with varying concentrations of blue-blocking dye was fabricated and the transmission spectrum of each lens was measured as shown in FIG. 45. Perylene concentrations of 35, 15, 7.6, and 3.8 ppm (weight basis) at a lens thickness of 2.2 mm were used. Various metrics calculated for each lens are shown in Table IV, with references corresponding to the reference numerals in FIG. 45. Since the selective absorbance of light depends primarily on the product of the dye concentration and coating thickness according to Beer's law, it is believed that comparable results are achievable using a hard coat and / or primer coat in conjunction with or instead of a film.

TABLE IVPhotopicScotopicPhoto-CircadianRatioRatiotoxicityRatioVλV′λRatio (Bλ)(M′λ)Ref.(%)(%)(%)(%)Unfiltered100100100100Polycarbonate-451087.5%87.1%74.2%85.5%undyed3.8 ppm (2.2 mm)452088.6%86.9%71.0%78.8%7.6 ppm (2.2 mm)453087.0%84.1%65.9%71.1%15 ppm (2.2 mm)454088.3%83.8%63.3%63.5%35 pp...

example 2

[0197]Nine patients were tested for contrast sensitivity using dye concentrations of 1× and 2× against a clear filter as a control. 7 of the 9 patients showed overall improved contrast sensitivity according to the Functional Acuity Contrast Test (FACT). See Table VI.

[0198]Table VI is a contrast sensitivity test for dye samples with loadings of X and 2X. Test was done in February 2007 at Vision Associates in Havre de Grace, Md. by Dr. Andy Ishak. The test consisted of 10 patients, each tested with two filters, using the FACT contrast sensitivity testing process, with the following constraints. Seven of the 9 patients showed overall improved contrast sensitivity results (columns 33-35). Patients overall showed improvement in both eyes on 18 of the 20 opportunities (2 eyes×two filters×five FACT columns (rows 27-28). On average, patients improved by 2.3-3.4 for all 20 opportunities (row 25).

[0199]Having now fully set forth the preferred embodiment and certain modifications of the concep...

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Abstract

The present invention relates to ophthalmic systems and coatings comprising a selective light wavelength filter, wherein said selective filter provides improved contrast sensitivity.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a division of U.S. application Ser. No. 11 / 933,069, filed Oct. 31, 2007, which claims priority to U.S. patent application Ser. No. 11 / 761,892 filed Jun. 12, 2007, which is a continuation-in-part of U.S. patent application Ser. No. 11 / 378,317 filed Mar. 20, 2006 and which claims priority to U.S. Provisional Application 60 / 812,628 filed Jun. 12, 2006. U.S. application Ser. No. 11 / 933,069 also claims priority to U.S. patent application Ser. No. 11 / 892,461 filed Aug. 23, 2007, which claims priority to U.S. Provisional Application 60 / 839,432 filed Aug. 23, 2006, U.S. Provisional Application 60 / 841,502 filed Sep. 1, 2006, and U.S. Provisional Application 60 / 861,247 filed Nov. 28, 2006. U.S. application Ser. No. 11 / 933,069 also claims priority to U.S. Provisional Application 60 / 978,175 filed Oct. 8, 2007. All of these applications are entirely incorporated by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the I...

Claims

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Application Information

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IPC IPC(8): G02C7/10A61F2/16G02C7/04
CPCG02C7/10G02C7/104G02C7/108G02C2202/16
Inventor ISHAK, ANDREW W.HADDOCK, JOSHUA N.KOKONASKI, WILLIAMDUSTON, DWIGHT P.VENKATRAMANI, IYER S.BLUM, RONALD D.MCGINNIS, SEAN P.PACKARD, MICHAEL B.
Owner ISHAK ANDREW W
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