Liposomes containing oligopeptide fragments of myelin basic protein, a pharmaceutical composition and a method for treatment of multiple sclerosis

a technology of myelin basic protein and liposome, which is applied in the direction of peptide/protein ingredients, peptide sources, immunodeficiency disorders, etc., can solve the problems of inflammatory demyelinating lesions in the brain and spinal cord, no existing therapies are capable of curing or preventing ms progression, and the formation of demyelination scarring and other problems, to achieve the effect of reducing paralysis, improving the intake of thes
US20130058994A1Inactive Publication Date: 2013-03-07LIPOXEN TECHNOLOGIES LTD
3 Cites 6 Cited by

Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
LIPOXEN TECHNOLOGIES LTD
Publication Date
2013-03-07
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention provides compositions and methods for the treatment of multiple sclerosis. Among others, the invention provides compositions of immunodominant peptides of myelin basic protein encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
Need to check novelty before this filing date? Find Prior Art

Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] The present application claims priority to International Application Serial Number PCT / RU2010 / 000710, filed on Nov. 29, 2010 and Russian Patent Application Serial Number RU 2009145056, filed on Nov. 30, 2009, the disclosures of which are hereby expressly incorporated by reference in their entireties for all purposes.BACKGROUND OF THE INVENTION

[0002] Multiple sclerosis (MS) is neurodegenerative disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring. The damage caused to the central nerve system (CNS) results in a wide spectrum of neurological symptoms. Approximately one million people worldwide suffer from this autoimmune disease, which has an enigmatic etiology and poorly understood pathogenesis. B- and T-cells reactive against components of the myelin membrane mediate the demyelination of the brain and spinal cord and appear to be responsible for a large ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More