Anti-microbial composition

Abstract

This invention pertains to an anti-microbial, in particular anti-bacterial and / or anti-fungal composition comprising cinnamaldehyde, trans-2-methoxy cinnamaldehyde, cinnamyl acetate and linalool. In particular this composition is intended for preventing and / or treating microbial infection in an animal.

Description

[0001]This invention pertains to an anti-microbial, in particular anti-bacterial, more particularly against Gram− bacteria, and / or anti-fungal and / or anti-viral composition comprising cinnamaldehyde, trans-2-methoxycinnamaldehyde, cinnamyl acetate and linalool. In particular this composition is intended for preventing and / or treating microbial infection in an animal.[0002]The arrival of penicillin followed by streptomycin in the 40s opened the era of anti-bacterials. The discovery of anti-bacterial compounds such as penicillin, aminosides, macrolides and quinolones have been one of the biggest achievement of the modern medicine for the treatment of bacterial infections.[0003]However, there is a growing need for new compounds or compositions allowing fighting bacterial infections. This need is in particular due to the fact that there is more and more microbes which are exhibiting various drug resistance to known anti-microbial compounds or compositions.[0004]For example in the case o...

AI Technical Summary

Benefits of technology

The patent text talks about how bacteria are becoming resistant to traditional anti-bacterial drugs. This is because they have developed multiple resistance mechanisms. However, the text also mentions that there are some viruses, like HIV and herpes viruses, that are not as likely to develop resistance. These viruses are also less likely to cause harmful side effects or cross-drug resistance. The patent text also mentions that certain antiviral drugs can be easily obtained through analytical processes and are both cost-effective and easy to use.

Problems solved by technology

For example in the case of bacteria it becomes a major problem to find novel efficient anti-bacterial compositions to prevent or treat bacterial infections.

Apparition and propagation of microbial strains resistant to almost all or even to all the known anti-microbial agents becomes a major health issue.

Known anti-microbial agents may exhibit the following drawbacks they may have an insufficient activity, in particular at low level and / or when interfering agent are present, they may be insufficiently active or not active at all on some or on any drug resistant microbes, in particular on drug resistant bacteria such as drug resistant Staphylococcus aureus, for example such as MRSA, VRSA; drug resistant enterobacter, such as NDM-1, or New Dehli Metallo-beta-lactamase type 1; they may presenting undesirable side effects, they may not be well tolerated by the organism, their use may lead to bacteria having drug resistance, in particular crossed drug resistance, they may be expensive, and / or difficult to obtain.

More particularly cinnamon essential oils, especially those comprising trans-cinnamaldehyde, or trans-cinnamaldehyde alone are known to be a potent anti-microbial, however, they lead to undesirable effects, such as neurotoxicity, which may lead to death in case of high dose, hepatotoxicity, irritation of the skin, sensitization of the skin, phototoxicity and / or photoallergy.

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