Slide Scanner with a Tilted Image
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second embodiment
[0032]FIG. 4 shows a slide scanner 450 for transmission imaging that is this invention. A tissue specimen 400 (or other specimen to be imaged) mounted on microscope slide 401 is illuminated from below by illumination source 110. Light passing through the specimen is collected by infinity-corrected microscope objective 115 which is focused on the specimen by piezo positioner 120 (or other focusing mechanism). The microscope objective 115 and tube lens 125 form a real image of the specimen on linear detector array 425, which can be tilted about tilt axis 430 using piezoelectric pusher 420 (or other tilt mechanism). The long dimension of linear detector array 425 is perpendicular to scan direction 102. Tilt axis 430 is parallel to scan direction 102. An image of the specimen is collected by moving the microscope slide at constant speed using motorized stage 405 in a direction perpendicular to the long dimension of the detector array 425, combining a sequence of equally-spaced line imag...
fourth embodiment
[0038]In FIG. 5, if TDI detector array 525 is replaced by an ordinary two-dimensional (2D) detector array (not a TDI array), then Moving Specimen Image Averaging can be used to acquire fluorescence image strips as described above. This is this invention. Both focus position and tilt can be measured by performing a Z-scan at several Y positions along each strip before scanning, with the detector tilt set at zero. With the detector parallel to the scan plane, a Z-scan can be performed by moving the microscope objective in the Z direction using the piezo positioner to a series of equally-spaced positions in Z, while storing the resulting series of 2D images, each of which has the same width as the scan strip, using the 2D detector (or alternatively, a Z-scan can be performed by moving either the detector or the specimen in the Z direction). This results in a 3D image stack at each Y position, and if the detector used as an example in the description above is used, this image stack cont...
PUM
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Abstract
Description
Claims
Application Information
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