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Synthesis of molecule on nanoparticle surface for stable detection of nitroaromatic explosives, and sensor using same

Inactive Publication Date: 2015-04-23
POSTECH ACAD IND FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a nanoparticle that can be used to develop a stable explosive sensor. It can remain stable even in different pH and ion intensity levels, making it ideal for detecting explosives dissolved in sea water. This technology enables efficient and reliable detection of explosives, even in challenging environments.

Problems solved by technology

Research and development into methods of detecting chemicals contained in explosives using ion mobility spectroscopy or neutron detection is ongoing, but these methods are problematic because of relatively long detection time and high cost, compared to when using biosensors.
However, the nanoparticles conventionally used to detect TNT are configured such that a portion of the surface ligand bound to the nanoparticles is a thiol group and thus bonding force with the nanoparticles is comparatively weak, and the other terminal is made up of a primary amine group and thus sensitively reacts depending on changes in pH or ion intensity, thus forming a cluster of nanoparticles or deteriorating the dispersion force.

Method used

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  • Synthesis of molecule on nanoparticle surface for stable detection of nitroaromatic explosives, and sensor using same
  • Synthesis of molecule on nanoparticle surface for stable detection of nitroaromatic explosives, and sensor using same
  • Synthesis of molecule on nanoparticle surface for stable detection of nitroaromatic explosives, and sensor using same

Examples

Experimental program
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example 1

Synthesis of CdSe / CdS / ZnS (Core / Shell / Shell) Quantum Dots

[0042]Synthesis of quantum dots disclosed herein is merely illustrative and is not construed as limiting the present invention.

[0043]For quantum dots having high fluorescence efficiency, CdSe quantum dots were synthesized via high-temperature pyrolysis in an organic solvent and then covered with CdS / ZnS shells, thus synthesizing quantum dots having a structure of CdSe / CdS / ZnS (core / shell / shell).

[0044]Specifically, cadmium selenide (CdSe) quantum dots were synthesized via modification of the method reported by Yu and Peng (W. W. Yu and X. Peng. Angew. Chem. Int. Edit. 2002, 41, 2368-2371). In a septum vial, 0.75 g (2.4 mmol) of cadmium acetate and 1.8 mL (6.0 mmol) of oleic acid were placed and dissolved at 100° C. in a vacuum. The completely dissolved cadmium acetate was cooled to room temperature, and then mixed with a solution of 0.47 g of selenium in 6 mL of trioctylphosphine (TOP). 15 mL of octadecene and 4 mL (12 mmol) of...

example 2

Synthesis of Ligand on Nanoparticle Surface with Terminal Amine

[0046]A ligand on the quantum dot surface was synthesized by binding (±)-α-lipoic acid with N,N-dimethylethylendiamine. The synthesis procedure is schematically shown in FIG. 1. Then, (±)-α-lipoic acid (20 mmol) and 1,1′-carbonyldiimidazole (26 mmol) were dissolved in 30 mL of anhydrous chloroform and stirred at room temperature for 20 min in the presence of nitrogen gas. This solution was added droplets into a flask containing N,N-dimethylethylendiamine (100 mmol) in an ice bath in the presence of nitrogen gas, and stirred for 2 hr. The product (LA-N(CH3)2) was washed three times with a 10% NaCl aqueous solution (80 mL) and two times with a 10 mM NaOH aqueous solution (80 mL), and then dewatered with magnesium sulfate.

example 3

Surface Modification of Quantum Dots

[0047]The surface of the CdSe / CdS / ZnS quantum dots synthesized in Example 1 was modified with the LA-N(CH3)2 ligand synthesized in Example 2. LA-N(CH3)2 (0.1 mmol) was dispersed in 2 mL of chloroform, and then dispersed in 2 mL of water with the addition of an aqueous solution about pH 4. The aqueous solution containing dispersed LA-N(CH3)2 was added with NaBH4 (0.2 mmol), so that disulfide bonding of LA-N(CH3)2 was reduced, thus forming dihydrolipoic acid-tertiary amine (DHLA-N(CH3)2). The pH value was raised to about 10, and DHLA-N(CH3)2 was dispersed in chloroform, added with CdSe / CdS / ZnS quantum dots (1 nmol) dispersed in chloroform, and stirred at 60° C. for about 3 hr in the presence of nitrogen gas. The pH value was lowered to about 5, and the surface-modified quantum dots were dispersed in the aqueous solution and dialyzed using a 50,000 centrifugal filter, thus removing the surplus ligand. Based on the absorption and fluorescence spectrum...

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Abstract

The present invention relates to a nanoparticle-based nitroaromatic explosive sensor for detecting nitroaromatic compounds, more specifically to stably detecting explosives in an aqueous solution by introducing, on the surface of the nanoparticles, a molecule which improves the dispersion force of the nanoparticles in an aqueous solution while binding strongly therewith, and which can simultaneously bind with the nitroaromatic compounds.

Description

TECHNICAL FIELD[0001]The present invention relates to a nanoparticle-based nitroaromatic explosive sensor for detecting nitroaromatic compounds, and more particularly, to stable detection of explosives in an aqueous solution by introducing, on the surface of nanoparticles, a molecule that may enhance dispersion force of the nanoparticles in an aqueous solution while being strongly bound to the nanoparticles, and also that may be coupled with nitroaromatic compounds.BACKGROUND ART[0002]Typical compounds useful as explosives include nitroaromatic chemicals such as trinitrotoluene (TNT) or dinitrotoluene (DNT). A variety of methods for detecting such chemicals have been developed.[0003]Research and development into methods of detecting chemicals contained in explosives using ion mobility spectroscopy or neutron detection is ongoing, but these methods are problematic because of relatively long detection time and high cost, compared to when using biosensors.[0004]Furthermore, sensors usi...

Claims

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Application Information

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IPC IPC(8): G01N33/22
CPCG01N33/227G01N33/1826Y10T436/173076G01N33/22G01N21/64C07C321/04C07C233/02
Inventor KIMWON, NAYOUNKWAG, JUNGHEONPARK, JOONHYUCKJIN, HO
Owner POSTECH ACAD IND FOUND
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